•IL-6, IL-8, IL-10, IL-17A, sTNF-RII were higher in HS patients than in the HCs.•Adalimumab improved T-helper-17 lymphocyte- and neutrophil-related ISMs.•Adalimumab decreased serum levels of 7 ...cytokines, and CRP and the ESR in HS patients.•IL-6, IL-8, sTNF-RI, and CRP and the ESR are correlated with clinical improvements.•They may serve as novel biomarkers for a therapeutic response.
T-helper (Th)-17 lymphocytes and neutrophils are the main sources of the proinflammatory cytokines involved in the pathogenesis of hidradenitis suppurativa (HS).
This study aims to evaluate the improvement of the inflammatory serum markers (ISM) levels in patients with moderate-to-severe HS who receive adalimumab.
Nineteen moderate-to-severe HS patients were prospectively recruited. Each of the patients received 40 mg of adalimumab weekly. The ISM levels and modified Hidradenitis Suppurativa Score (mHSS) scores were assessed at baseline and at week 36. Nineteen healthy volunteers (HC) constituted the control group.
Before adalimumab treatment, the HS patients showed significantly increased levels of interleukin (IL)-6, IL-8, IL-10, IL-17A, soluble TNF receptor II (sTNF-RII), and C-reactive protein (CRP) as well as an increased erythrocyte sedimentation rate (ESR) (all P < .01). At week 36, the circulating levels of IL-1β, IL-6, IL-8, IL-10, IL-17A, soluble TNF receptor I (sTNF-RI), sTNF-RII, and CRP, as well as the ESR (all P < .05), decreased significantly in the HS patients who received adalimumab. The decrease in levels of IL-6 (r = 0.65, P = .003), IL-8 (r = 0.52, P = .024), sTNF-RI (r = 0.55, P = .015), and CRP (r = 0.47, P < .040) and the ESR (r = 0.60, P < .006) were significantly well correlated with clinical improvements according to the mHSS.
Adalimumab improves the ISM-based systemic inflammatory burden in patients with moderate-to-severe HS. IL-6, IL-8, sTNF-RI and CRP and the ESR may serve as novel biomarkers for a therapeutic response.
Vesiculobullous variant of erythema elevatum diutinum Ossorio‐García, L.; Jiménez‐Gallo, D.; Arjona‐Aguilera, C. ...
Clinical and experimental dermatology,
October 2017, 2017-Oct, 2017-10-00, 20171001, Letnik:
42, Številka:
7
Journal Article
Recenzirano
Summary
The vesiculobullous variant of erythema elevatum diutinum (EED) is a very rare variant of EED. We describe a 16‐year‐old boy who presented with symmetrical nodular lesions accompanied by ...vesicles on the dorsa of his hands. Biopsy findings were consistent with EED. The histopathological presence of IgA and neutrophils in the vesicles indicates that the joint action of both is responsible for formation of these subepidermic vesicles. We hypothesize that absence of human leucocyte antigen related to dermatitis herpetiformis (DH) in our patient might have influenced the location and distribution of the lesions, so that they were not typical of DH. We report the second case of the vesiculobullous variant of EED with IgA deposits in the dermoepidermal membrane. To our knowledge, there are only 14 previously reported cases of the vesiculobullous variant of EED.
Calcinosis cutis (CC) is defined as the deposition of calcium salts in the skin. The condition is divided into 5 types: calciphylaxis and dystrophic, metastatic, idiopathic, and iatrogenic CC. ...Dystrophic CC is the most common form and usually occurs in association with autoimmune diseases. CC can be treated surgically or with the use of drugs such as diltiazem, bisphosphonates, warfarin, ceftriaxone, probenecid, minocycline, or aluminum hydroxide. Calciphylaxis is defined as calcification of the media of small- and medium-sized blood vessels in the dermis and subcutaneous tissue. Clinically, calciphylaxis causes livedo racemosa, which progresses to retiform purpura and skin necrosis. First-line treatment is with sodium thiosulfate. We present a review of the calcifying disorders of the skin, focusing on their diagnosis and treatment.
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