Accuracy of long-form data in the Taiwan cancer registry Kao, Chia-Wen; Chiang, Chun-Ju; Lin, Li-Ju ...
Journal of the Formosan Medical Association,
November 2021, 2021-11-00, 20211101, 2021-11-01, Letnik:
120, Številka:
11
Journal Article
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The Taiwan Cancer Registry (TCR) is a nationwide population-based registry that collects the data of patients with newly diagnosed cancer from hospitals with ≥50 beds. TCR data are high quality in ...terms of completeness and timeliness. However, accuracy is also a crucial quality indicator. This study evaluated the accuracy rates of selected 55 major items in the long-form TCR data between 2014 and 2016 with 700 reported cases randomly selected from 25 long-form-reporting hospitals. We calculated the accuracy rates of the reported data by employing a reabstracted chart review. Among the 55 items, the accuracy rates of 38 (69%) were at least 95%, those of 10 (18%) were between 90% and 95%, those of 5 (9%) were between 85% and 90%, and the remaining 2 (4%) were between 80% and 85%. This demonstrates a high degree of accuracy in the TCR long-form data.
The incidence of type 2 diabetes(T2DM)is rapidly increasing worldwide.However,the pathogenesis of T2DM has not yet been well explained.Recent evidence suggests that the intestinal microbiota ...composition is associated with obesity and T2DM.In this review,we provide an overview about the mechanisms underlying the role of intestinal microbiota in the pathogenesis of T2DM.There is clear evidence that the intestinal microbiota influences the host through its effect on body weight,bile acid metabolism,proinflammatory activity and insulin resistance,and modulation of gut hormones.Modulating gut microbiota with the use of probiotics,prebiotics,antibiotics,and fecal microbiota transplantation may have benefits for improvement in glucose metabolism and insulin resistance in the host.Further studies are required to increase our understanding of the complex interplay between intestinal microbiota and the host with T2DM.Further studies may be able to boost the development of new effective therapeutic approaches for T2DM.
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with droplets and contact as the main means of transmission. Since ...the first case appeared in Wuhan, China, in December 2019, the outbreak has gradually spread nationwide. Up to now, according to official data released by the Chinese health commission, the number of newly diagnosed patients has been declining, and the epidemic is gradually being controlled. Although most patients have mild symptoms and good prognosis after infection, some patients developed severe and die from multiple organ complications. The pathogenesis of SARS-CoV-2 infection in humans remains unclear. Immune function is a strong defense against invasive pathogens and there is currently no specific antiviral drug against the virus. This article reviews the immunological changes of coronaviruses like SARS, MERS and other viral pneumonia similar to SARS-CoV-2. Combined with the published literature, the potential pathogenesis of COVID-19 is inferred, and the treatment recommendations for giving high-doses intravenous immunoglobulin and low-molecular-weight heparin anticoagulant therapy to severe type patients are proposed.
Cu‐based metal–organic frameworks have attracted much attention for electrocatalytic CO2 reduction, but they are generally instable and difficult to control the product selectivity. We report ...flexible Cu(I) triazolate frameworks as efficient, stable, and tunable electrocatalysts for CO2 reduction to C2H4/CH4. By changing the size of ligand side groups, the C2H4/CH4 selectivity ratio can be gradually tuned and inversed from 11.8 : 1 to 1 : 2.6, giving C2H4, CH4, and hydrocarbon selectivities up to 51 %, 56 %, and 77 %, respectively. After long‐term electrocatalysis, they can retain the structures/morphologies without formation of Cu‐based inorganic species. Computational simulations showed that the coordination geometry of Cu(I) changed from triangular to tetrahedral to bind the reaction intermediates, and two adjacent Cu(I) cooperated for C−C coupling to form C2H4. Importantly, the ligand side groups controlled the catalyst flexibility by the steric hindrance mechanism, and the C2H4 pathway is more sensitive than the CH4 one.
Flexible Cu(I) triazolate frameworks functionalized with dinuclear copper sites can serve as highly stable and efficient electrocatalysts for CO2 reduction to C2H4/CH4, and the selectivity is tunable by the size of uncoordinated ligand side groups.
A
bstract
We show that F-theory compactifications with abelian gauge factors generally exhibit a non-trivial global gauge group structure. The geometric origin of this structure lies with the Shioda ...map of the Mordell-Weil generators. This results in constraints on the
u
1
charges of non-abelian matter consistent with observations made throughout the literature. In particular, we find that F-theory models featuring the Standard Model algebra actually realise the precise gauge group SU(3) × SU(2) × U(1)/
ℤ
6
. Furthermore, we explore the relationship between the gauge group structure and geometric (un-)higgsing. In an explicit class of models, we show that, depending on the global group structure, an
s
u
2
⊕
u
1
gauge theory can either unhiggs into an SU(2) × SU(2) or an SU(3) × SU(2) theory. We also study implications of the charge constraints as a criterion for the F-theory ‘swampland’.
CCCH-type zinc-finger antiviral protein (ZAP) is a host factor that restricts the infection of many viruses mainly through RNA degradation, translation inhibition and innate immune responses. So far, ...only one flavivirus, yellow fever virus, has been reported to be ZAP-resistant. Here, we investigated the antiviral potential of human ZAP (isoform ZAP-L and ZAP-S) against three flaviviruses, Japanese encephalitis virus (JEV), dengue virus (DENV) and Zika virus (ZIKV). Infection of JEV but not DENV or ZIKV was blocked by ZAP overexpression, and depletion of endogenous ZAP enhanced JEV replication. ZAP hampered JEV translation and targeted viral RNA for 3'-5' RNA exosome-mediated degradation. The zinc-finger motifs of ZAP were essential for RNA targeting and anti-JEV activity. JEV 3'-UTR, especially in the region with dumbbell structures and high content of CG dinucleotide, was mapped to bind ZAP and confer sensitivity to ZAP. In summary, we identified JEV as the first ZAP-sensitive flavivirus. ZAP may act as an intrinsic antiviral factor through specific RNA binding to fight against JEV infection.
A
bstract
We initiate the systematic investigation of non-flat resolutions of non-minimal singularities in elliptically fibered Calabi-Yau threefolds. Compactification of M-theory on these geometries ...provides an alternative approach to studying phases of five-dimensional superconformal field theories (5d SCFTs). We argue that such resolutions capture non-trivial holonomies in the circle reduction of the 6d conformal matter theory that is the F-theory interpretation of the singular fibration. As these holonomies become mass deformations in the 5d theory, non-flat resolutions furnish a novel method in the attempt to classify 5d SCFTs through 6d SCFTs on a circle. A particularly pleasant aspect of this proposal is the explicit embedding of the 5d SCFT’s enhanced flavor group inside that of the parent 6d SCFT, which can be read off from the geometry. We demonstrate these features in toric examples which realize 5d theories up to rank four.
In this work, we report the synthesis and assessment of a new non-precious-metal oxygen reduction reaction (ORR) catalyst from pyrolysis of an iron-coordinated complex which manifests superior ...activity in both alkaline and acidic media. 11,11′-bis(dipyrido3,2-a:2′,3′-cphenazinyl) (bidppz) was selected as a ligand for the formation of a nitrogen-rich iron-coordinated coordination polymer (Fe–bidppz) which forms a self-supporting catalyst containing high densities of nitrogen and iron doping by pyrolysis. The catalyst pyrolyzed at 800 °C (Fe–N/C-800) shows the highest ORR activity with onset and half-wave potentials of 923 and 809 mV in 0.1 M KOH, respectively, which are comparable to those of Pt/C (half-wave potential 818 mV vs RHE) at the same catalyst loading. Besides, the Fe–N/C-800 catalyst has an excellent ORR activity with onset and half-wave potentials only 38 and 59 mV less than those of the Pt/C catalyst in 0.1 M HClO4. The optimal Fe–N/C-800 catalyst displays much greater durability and tolerance of methanol than Pt/C. We propose that the Fe–N/C-800 catalyst has a considerably high density of surface active sites because Fe–N/C-800 possesses excellent ORR activity while its specific surface area is not so high. Electrochemical measurements show that the Fe–N/C-800 catalyst in KOH and HClO4 follows the effective four-electron-transfer pathway.
This study aimed to compare the clinical effects of the Medis flexible laryngeal mask airway (FLMA) with those of the Ambu AuraFlex FLMA in pediatric ophthalmic surgery. A total of 80 patients, aged ...1 to 5 years, in American Society of Anesthesiologists I-II, weighing ≥10 kg, and without any existing airway difficulties, were enrolled in this study. The patients were randomly divided into Group M (Medis FLMA) and Group A (Ambu AuraFlex FLMA). The time of insertion, number of attempts, finger assistance required, manipulation, oropharyngeal leak pressure (OLP), fiberoptic grade of view, and complications such as bloodstaining, hoarseness, and sore throat were recorded. Group M showed a significantly higher OLP than did Group A (P = .002); however, Group M required more finger assistance than did Group A (P = .009). There were no statistically significant differences between the 2 groups in terms of insertion time, number of attempts, manipulation, fiberoptic view grade, or complications. Both the Medis and Ambu AuraFlex FLMA can provide smooth ventilation during pediatric ophthalmic surgeries. The Medis FLMA showed a higher OLP than did the Ambu AuraFlex FLMA but required more finger assistance during insertion.
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