Crowd counting with density estimation has been an active research community due to its significant applications in the fields of public security, video surveillance, traffic monitoring. However, ...Crowd counting for congested scenes often suffers from some obstacles including severe occlusions, large scale variations, noise interference, etc. In this paper, using the first ten layers of a modified VGG16 and dilated convolution layers as the framework, we have proposed a CNN based crowd counting and density estimation model improved by the attention aware modules with residual connections. To tackle the problem of noise interference, convolutional block attention modules have been introduced into the deep network to segment the foreground and background to focus on interest information, refining deeper features of the input image. To improve information transmission and reuse, residual connections are utilized to link 3 attention blocks. Meanwhile, dilated convolution layers keep larger reception fields and obtain high-resolution density maps. The proposed method has been evaluated on three public benchmarks, i.e. Shanghai Tech A & B, UCF-QNRF and MALL, achieving the mean absolute errors of 64.6 & 8.3, 113.8 and 1.68, respectively. The results outperform some existing excellent approaches. This indicates that the proposed model has high accuracy and better robustness, which is suitable for crowd counting and density estimation in various congested scenes.
Under the requirement of everything over IP, network service shows the following characteristics:(1) network service increases its richness;(2) broadband streaming media becomes the mainstream. To ...achieve unified multi-service bearing in the IP network, the largescale access convergence network architecture is proposed. This flat access convergence structure with ultra-small hops, which shortens the service transmission path, reduces the complexity of the edge of the network, and achieves IP strong waist model with the integration of computation, storage and transmission. The key technologies are also introduced in this paper, including endto-end performance guarantee for real time interactive services, fog storing mechanism, and built-in safety transmission with integration of aggregation and control.
Cancer is one of the main diseases threatening human health in the world. Doxorubicin (DOX) is a common anti-cancer drug that can be used for chemotherapy to extend a cancer patient's life. It is our ...common wish that treatment process of cancer is efficient and secure. Therefore, it is of great significance to develop sensitive, rapid and accurate techniques for anti-cancer drug doxorubicin (DOX) detection. Herein, in our work, a ratiometric electrochemical sensor for DOX detection was designed, which based on MB@MWCNTs/UiO-66-NH2 composites. The porous materials UiO-66-NH2 magically shoulder double function in our ratiometric electrochemical strategy, which can reduce the interior error caused by the various complex materials. Specifically, on the one hand, it can be used to catalyze DOX, which can provide a great current signal to be detected, on the other hand, its special property of absorbing molecules was utilized to load materials as internal reference. Consequently, we chose methylene blue (MB) as the substance that can generate an internal reference signal, because it is a specific and stable electroactive substance. Then, we added MWCNTs as a part of the material modified on the ratiometric electrochemical platform to enhance the signal of the target due to its feature of good electrical conductivity. Under the optimized conditions, the ratiometric electrochemical sensor displayed a wide linear detection with the range from 0.1 μM to 75 μM and the limit of detection (LOD) of 0.051 μM. The applicability of this method in the analysis of actual human saliva samples has been confirmed by the results of selectivity, stability, and reproducibility tests, which was prospective in clinical application.
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•Multiple function MOF was designed for ratiometric electrochemical detection of DOX.•The UiO-66-NH2/MWCNTs can bring catalytic reaction towards target to amplify the detection signal.•The multiple function MOF platform can be extended for analysis of other target.
Gastric cancer remains the third leading cause of cancer-related mortality worldwide, and invasion and metastasis of gastric cancer represent the major reason for its poor prognosis. Glutamine: ...fructose-6-phosphate amidotransferase 1 (GFAT1) is the first and rate-limiting enzyme of hexosamine biosynthesis pathway (HBP). Nevertheless, the role of GFAT1 in gastric cancer is little investigated. In this study, we found that the expression of GFAT1 was decreased in gastric cancer. Low expression of GFAT1 was positively associated with vessel invasion, late T stage, lymph node metastasis, distant metastasis, advanced TNM stage and poor prognosis in patients with gastric cancer. Furthermore, in vitro and in vivo studies revealed that down-regulation of GFAT1 promoted epithelial-to-mesenchymal transition (EMT) and invasive activities in gastric cancer cells through inducing the expression of TGF-β1. The GFAT1 expression also significantly correlated with EMT-related factors in gastric cancer patients. Together, these findings indicate that GFAT1 functions as a novel suppressor of EMT and tumor metastasis in gastric cancer.
Carbon nano-dots were synthesized by a hydrothermal method and integrated into the poly(vinyl alcohol) matrix as charge carrier trapping centers for nonvolatile memory devices. The devices with the ...configuration of ITO/carbon nano-dots-PVA/Ag exhibited bistable electrical switching at low voltage, long retention time and excellent reading stability.
Carbon nano-dots were synthesized by a hydrothermal method and integrated into the poly(vinyl alcohol) matrix as charge carrier trapping centers for nonvolatile memory devices. The devices with the ...configuration of ITO/carbon nano-dots-PVA/Ag exhibited bistable electrical switching at low voltage, long retention time and excellent reading stability.
Carbon nano-dots were synthesized by a hydrothermal method and integrated into the poly(vinyl alcohol) matrix as charge carrier trapping centers for nonvolatile memory devices.
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