We consider the non-resonance with one-sided superlinear growth conditions for the indefinite planar system $ z' = f(t, z) $ from a rotation number viewpoint, and obtain the existence of $ 2\pi ...$-periodic solutions by applying a rotation number approach together with the Poincaré-Bohl theorem. We allow that the angular velocity of solutions of $ z' = f(t, z) $ is controlled by the angular velocity of solutions of two positively homogeneous and oddly symmetric systems $ z' = L_i(t, z), i = 1, 2 $ on the left half-plane, which have rotation numbers that satisfy $ \rho(L_1) > n/2 $ and $ \rho(L_2) < (n+1)/2 $, and allow $ f(t, z) $ to grow superlinearly on the right half-plane. In order to estimate the rotation angle difference of solutions, we develop a system methodology of "tracking" the angle difference of solutions of the system $ z' = f(t, z) $ on each small interval on the given side under sign-varying conditions.
In order to build an intelligent tourism innovation ability evaluation system, this paper uses data mining technology to mine tour-ism information, combines modern people's tourism needs to construct ...a regional innovation ability evaluation system, and detects the effect of data mining with the support of logistic regression analysis. Moreover, this paper uses the life cycle theory framework to analyze the life cycle stages of regional tourism destinations, analyzes the internal factors that form the characteristics and laws of specific stages, and takes timely measures to artificially control and adjust the problems that need attention. In addition, this paper constructs an evaluation system of tourism innovation capability with intelligent effects. On this basis, this paper combines experimental analysis to evaluate the system constructed in this paper, and takes Guilin regional tourism as an example to perform the analysis. The research results show that the system constructed in this paper has a certain effect, and the corresponding suggestions are given.
•Doxorubicin induces myocardial pyroptosis to cause cardiac dysfunction.•Pinocembrin inhibits cell pyroptosis to protect hearts from DOX-induced toxicity.•Pinocembrin reduces cell pyroptosis via ...activating Nrf2/Sirt3 signal pathway.
Doxorubicin (DOX) is a potent chemotherapeutic drug but the clinical use was limited by its dose-dependent cardiotoxicity. Pinocembrin (PCB), a flavonoid originally isolated from honeybee propolis and rhizomes of Boesenbergia pandurate displays diverse biological activities. However, the role of PCB in DOX-induced cardiac injury and its underlying molecular mechanism are not fully elucidated. The present study was designed to evaluate the protective role of PCB in a DOX-induced cardiotoxicity in vivo and in vitro. Our results revealed that PCB administration greatly improved cardiac function and reduced cardiac fibrosis manifested by LVEF, LVFS, LVIDd, LVIDs, and myocardial fibrotic area which were impaired by DOX treatment. The cardiac injury evidenced by LDH and CK-MB activities were reduced while the levels of IL-1β and IL-18 were decreased following PCB treatment compared to DOX-treated mice. Mechanically, our present results showed that PCB significantly inhibited DOX-induced cardiomyocyte pyroptosis via activating Nrf2/Sirt3 signal pathway. Furthermore, the inhibition of Nrf2 in H9c2 cells abolished the protective role of PCB against DOX-induced cell toxicity, which was at least partly via upregulation of NLRP3-mediated pyroptosis. In conclusion, our study clearly demonstrated that PCB reduced cardiomyocyte pyroptosis to protect hearts from DOX-induced cardiotoxicity through activation of Nrf2/Sirt3 signal pathway.
Superhydrophobic surfaces (SHSs) have received significant attention due to their low surface energy, which facilitates droplet dewetting transition and promotes jumping condensation. However, at ...high subcooling temperatures, SHSs encounter challenges in maintaining their performance. They are prone to issues like nucleation-induced flooding condensation and reduced hydrophobicity. To address the limitations of SHSs at high subcooling temperatures, we propose the concept of superhydrophobic lubricant-infused surfaces (LISs). These combine the advantages of superhydrophobicity with enhanced functionality provided by a lubricant layer. Firstly, the wetting and adhesion of droplets on LISs have been explored, considering the effects of substrate characteristic and lubricant thickness. Subsequently, the surface condensation on both LISs and SHSs at high subcooling temperatures has been investigated. The failure modes of SHSs at high subcooling temperatures have been revealed. Our molecular dynamics simulations demonstrate that by infusing a superhydrophobic lubricant, the LISs can effectively overcome the limitations of SHSs. This enables the maintenance of dewetting property and ensures droplet jumping condensation, even at high subcooling temperatures. Finally, a comprehensive map is developed to compare the static wettability and dynamic wettability during condensation under different substrate characteristics and lubricant thicknesses. The present work can provide valuable insights into the potential of LISs in addressing the limitations of SHSs. It paves the way for applications in various fields, such as self-cleaning, anti-icing, moisture resistance, drag reduction, and enhanced heat transfer performance.
We prove the existence of multiple periodic solutions for weakly coupled parametrized systems with a singularity of repulsive type at the origin and linear growth at infinity. The proof is based on a ...higher dimensional Poincaré-Birkhoff theorem and the phase-plane analysis of the solutions.
We investigate the existence of multiple periodic solutions for a class of second order parameter-dependent equations of the form $ x''+f(t, x) = sp(t) $. We compare the behavior of its solutions ...with suitable linear and piecewise linear equations near positive infinity and infinity. Furthermore, in this context, the nonlinearity $ f $ does not satisfy the usual sign condition, and the global existence of solutions for the Cauchy problem associated to the equation is not guaranteed. Our approach is based on the Poincaré-Birkhoff twist theorem, a rotation number approach and the phase-plane analysis. Our result generalizes the result in Fonda and Ghirardelli <xref ref-type="bibr" rid="b1">1 for second order parameter-dependent equations.
In this study, we investigated the therapeutic effects and mechanism of atractylodin (ATL) on dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. We found that atractylodin could ...significantly reverse the effects of DSS-induced ulcerative colitis, such as weight loss, disease activity index score; shorten the colon length, and reverse the pathological changes in the colon of mice. Atractylodin could inhibit the activation of colonic macrophages by inhibiting the MAPK pathway and alleviate intestinal inflammation in the mouse model of ulcerative colitis. Moreover, it could protect the intestinal barrier by inhibiting the decrease of the tight junction proteins, ZO-1, occludin, and MUC2. Additionally, atractylodin could decrease the abundance of harmful bacteria and increase that of beneficial bacteria in the intestinal tract of mice, effectively improving the intestinal microecology. In an LPS-induced macrophage model, atractylodin could inhibit the MAPK pathway and expression of the inflammatory factors of macrophages. Atractylodin could also inhibit the production of lactate, which is the end product of glycolysis; inhibit the activity of GAPDH, which is an important rate-limiting enzyme in glycolysis; inhibit the malonylation of GAPDH, and, thus, inhibit the translation of TNF-α. Therefore, ours is the first study to highlight the potential of atractylodin in the treatment of ulcerative colitis and reveal its possible mechanism.
Increasing global temperature and sea-level rise have led to concern about expansions in the distribution and prevalence of complex-lifecycle parasites (CLPs). Indeed, numerous environmental ...variables can influence the infectivity and reproductive output of many pathogens. Digenean trematodes are CLPs with intermediate invertebrate and definitive vertebrate hosts. Global warming and sea level rise may affect these hosts to varying degrees, and the effect of increasing temperature on parasite prevalence has proven to be nonlinear and difficult to predict. Projecting the response of parasites to anthropogenic climate change is vital for human health, and a longer term perspective (10 ⁴ y) offered by the subfossil record is necessary to complement the experimental and historical approaches of shorter temporal duration (10 ⁻¹ to 10 ³ y). We demonstrate, using a high-resolution 9,600-y record of trematode parasite traces in bivalve hosts from the Holocene Pearl River Delta, that prevalence was significantly higher during the earliest stages of sea level rise, significantly lower during the maximum transgression, and statistically indistinguishable in the other stages of sea-level rise and delta progradation. This stratigraphic paleobiological pattern represents the only long-term high-resolution record of pathogen response to global change, is consistent with fossil and recent data from other marine basins, and is instructive regarding the future of disease. We predict an increase in trematode prevalence concurrent with anthropogenic warming and marine transgression, with negative implications for estuarine macrobenthos, marine fisheries, and human health.
Significance There is growing concern about how parasites will respond to climate change. Previous studies were based on data from short time scales (10 ⁻¹ to 10 ³ y), but here we present, to our knowledge, the first analysis of the response of parasites to global change on a longer time scale (10 ⁴ y), utilizing the subfossil record. A 9,600-y record of clams and flatworm parasites from the Pearl River Delta exhibits a significant spike in parasite prevalence during the initial phase of sea-level rise. This increase is not related to changes in salinity or intermediate host availability. Temperature and productivity cannot be quantified and tested as driving factors. These results suggest stark implications for macrobenthos, fisheries, and human health in the context of climate change.
TiO2 has great potential for application in UV photodetectors due to its excellent photoelectric response. In this work, composite nanomaterials of TiO2 nanotube arrays (TiO2 NTAs) and polyaniline ...(PANI) were successfully prepared on titanium sheets using an anodic oxidation electrochemical method. The results showed that the TiO2 NTA/PANI composite materials had excellent UV photosensitivity and responsiveness and good stability and reproducibility. This was mainly attributed to the p–n heterostructure formed inside the TiO2 NTA/PANI composites that hindered the recombination of photogenerated electron–hole pairs and improved their utilization of UV light. This work provides a theoretical basis for the application of metal oxides in UV photodetectors, which is important for the development of UV photodetectors.
Linn. is a large genus within the family Asteraceae that includes several important medicinal plants. Because of their similar morphology and chemical composition, traditional identification methods ...often fail to distinguish them. Therefore, developing an effective identification method for
species is an urgent requirement. In this study, we analyzed 15 chloroplast (cp) genomes, including 12 newly sequenced genomes, from 5
species. The cp genomes from the five
species had a typical quadripartite structure and were highly conserved across species. They had varying lengths of 151,132-151,178 bp, and their gene content and codon preferences were similar. Mutation hotspot analysis identified four highly variable regions, which can potentially be used as molecular markers to identify
species. Phylogenetic analysis showed that the five
species investigated in this study were sister branches to each other, and individuals of each species formed a monophyletic clade. This study shows that the cp genome can provide distinguishing features to help identify closely related
species and has the potential to serve as a universal super barcode for plant identification.
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