Over the past two decades mounting evidence demonstrated that terrestrial weather significantly influences the dynamics and mean state of the thermosphere. While important progress has been made in ...understanding how this coupling occurs on hourly to daily time scales, large uncertainty still exists on this effect around intraseasonal (∼30–90 days) time scales. In this work, analyses of Thermosphere Ionosphere Mesosphere Energetics Dynamics‐Sounding of the Atmosphere using Broadband Emission Radiometry temperatures near 110 km and Gravity field and steady‐state Ocean Circulation Explorer cross‐track winds near 260 km reveal prominent intraseasonal oscillations in the equatorial (±15°) zonal mean lower and middle thermosphere. Similar intraseasonal oscillations are found in the amplitudes of the diurnal eastward propagating tide with Zonal Wavenumber 3 (DE3) and the quasi‐3‐day ultrafast Kelvin wave, two prominent ultrafast tropical waves (UFTWs) excited by deep tropical tropospheric convection. Numerical simulations from the Specified‐Dynamics Whole Atmosphere Community Climate Model eXtended demonstrate a significant connection between these UFTW and the Madden‐Julian Oscillation (MJO). Compared to the boreal winter mean state, thermospheric UFTW amplitudes are larger (+5 to +12%) during MJO Phases 2–3 and smaller (−3% to −12%) during MJO Phases 6–8. Significant variations are also found with respect to the phase of the mesospheric semiannual oscillation (MSAO) and stratospheric quasi‐biannual oscillation (SQBO), with larger (±12–16%) thermospheric amplitudes during westward MSAO/SQBO phase and smaller (±3–6%) amplitudes during eastward MSAO/SQBO phase, in accordance with theoretical interpretations. This study suggests that UFTW may play a large role in coupling tropospheric intraseasonal variability to the thermosphere, raising important questions including implications for the whole atmosphere system.
Key Points
The Madden‐Julian Oscillation (MJO) plays an important role in coupling tropical tropospheric intraseasonal variability to the thermosphere
Ultrafast tropical waves (e.g., DE3 and UFKW) are responsible for coupling tropical tropospheric intraseasonal variability to the thermosphere
Thermospheric ultrafast tropical wave amplitudes are found to be larger during MJO Phases 2–3 and during westward MSAO and SQBO phases
Cerebral infra-slow oscillation (ISO) is a source of vasomotion in endogenic (E; 0.005-0.02 Hz), neurogenic (N; 0.02-0.04 Hz), and myogenic (M; 0.04-0.2 Hz) frequency bands. In this study, we ...quantified changes in prefrontal concentrations of oxygenated hemoglobin (ΔHbO) and redox-state cytochrome c oxidase (ΔCCO) as hemodynamic and metabolic activity metrics, and electroencephalogram (EEG) powers as electrophysiological activity, using concurrent measurements of 2-channel broadband near-infrared spectroscopy and EEG on the forehead of 22 healthy participants at rest. After preprocessing, the multi-modality signals were analyzed using generalized partial directed coherence to construct unilateral neurophysiological networks among the three neurophysiological metrics (with simplified symbols of HbO, CCO, and EEG) in each E/N/M frequency band. The links in these networks represent neurovascular, neurometabolic, and metabolicvascular coupling (NVC, NMC, and MVC). The results illustrate that the demand for oxygen by neuronal activity and metabolism (EEG and CCO) drives the hemodynamic supply (HbO) in all E/N/M bands in the resting prefrontal cortex. Furthermore, to investigate the effect of transcranial photobiomodulation (tPBM), we performed a sham-controlled study by delivering an 800-nm laser beam to the left and right prefrontal cortex of the same participants. After performing the same data processing and statistical analysis, we obtained novel and important findings: tPBM delivered on either side of the prefrontal cortex triggered the alteration or reversal of directed network couplings among the three neurophysiological entities (i.e., HbO, CCO, and EEG frequency-specific powers) in the physiological network in the E and N bands, demonstrating that during the post-tPBM period, both metabolism and hemodynamic supply drive electrophysiological activity in directed network coupling of the prefrontal cortex (PFC). Overall, this study revealed that tPBM facilitates significant modulation of the directionality of neurophysiological networks in electrophysiological, metabolic, and hemodynamic activities.
Transcranial Photobiomodulation (tPBM) has demonstrated its ability to alter electrophysiological activity in the human brain. However, it is unclear how tPBM modulates brain electroencephalogram ...(EEG) networks and is related to human cognition. In this study, we recorded 64-channel EEG from 44 healthy humans before, during, and after 8-min, right-forehead, 1,064-nm tPBM or sham stimulation with an irradiance of 257 mW/cm
. In data processing, a novel methodology by combining group singular value decomposition (gSVD) with the exact low-resolution brain electromagnetic tomography (eLORETA) was implemented and performed on the 64-channel noise-free EEG time series. The gSVD+eLORETA algorithm produced 11 gSVD-derived principal components (PCs) projected in the 2D sensor and 3D source domain/space. These 11 PCs took more than 70% weight of the entire EEG signals and were justified as 11 EEG brain networks. Finally, baseline-normalized power changes of each EEG brain network in each EEG frequency band (delta, theta, alpha, beta and gamma) were quantified during the first 4-min, second 4-min, and post tPBM/sham periods, followed by comparisons of frequency-specific power changes between tPBM and sham conditions. Our results showed that tPBM-induced increases in alpha powers occurred at default mode network, executive control network, frontal parietal network and lateral visual network. Moreover, the ability to decompose EEG signals into individual, independent brain networks facilitated to better visualize significant decreases in gamma power by tPBM. Many similarities were found between the cortical locations of SVD-revealed EEG networks and fMRI-identified resting-state networks. This consistency may shed light on mechanistic associations between tPBM-modulated brain networks and improved cognition outcomes.
Our recent study demonstrated that prefrontal transcranial photobiomodulation (tPBM) with 1064-nm laser enables significant changes in EEG rhythms, but these changes might result from the ...laser-induced heat rather than tPBM. This study hypothesized that tPBM-induced and heat-induced alterations in EEG power topography were significantly distinct. We performed two sets of measurements from two separate groups of healthy humans under tPBM (n = 46) and thermal stimulation (thermo_stim; n = 11) conditions. Each group participated in the study twice under true and respective sham stimulation with concurrent recordings of 64-channel EEG before, during, and after 8-min tPBM at 1064 nm or thermo_stim with temperature of 33-41 °C, respectively. After data preprocessing, EEG power spectral densities (PSD) per channel per subject were quantified and normalized by respective baseline PSD to remove the power-law effect. At the group level for each group, percent changes of EEG powers per channel were statistically compared between (1) tPBM vs light-stimulation sham, (2) thermo_stim vs heat-stimulation sham, and (3) tPBM vs thermo_stim after sham exclusion at five frequency bands using the non-parametric permutation tests. By performing the false discovery rate correction for multi-channel comparisons, we showed by EEG power change topographies that (1) tPBM significantly increased EEG alpha and beta powers, (2) the thermal stimulation created opposite effects on EEG power topographic patterns, and (3) tPBM and thermal stimulations induced significantly different topographies of changes in EEG alpha and beta power. Overall, this study provided evidence to support our hypothesis, showing that the laser-induced heat on the human forehead is not a mechanistic source causing increases in EEG power during and after tPBM.
This article presents a low-cost and area-efficient 28-GHz CMOS phased-array beamformer chip for 5G millimeter-wave dual-polarized multiple-in-multiple-out (MIMO) (DP-MIMO) systems. A neutralized ...bi-directional technique is introduced in this work to reduce the chip area significantly. With the proposed technique, completely the same circuit chain is shared between the transmitter and receiver. To further minimize the area, an active bi-directional vector-summing phase shifter is also introduced. Area-efficient and high-resolution active phase shifting could be realized in both TX and RX modes. In measurement, the achieved saturated output power for the TX-mode beamformer is 15.1 dBm. The RX-mode noise figure is 4.2 dB at 28 GHz. To evaluate the over-the-air performance, 16 H+16 V sub-array modules are implemented in this work. Each of the sub-array modules consists of four 4 H+4 V chips. Two sub-array modules in this work are capable of scanning the beam from −50° to +50°. A saturated EIRP of 45.6 dBm is realized by 32 TX-mode beamformers. Within 1-m distance, a maximum SC-mode data rate of 15 Gb/s and the 5G new radio downlink packets transmission in 256-QAM could be supported by the module. A <inline-formula> <tex-math notation="LaTeX">2\times 2 </tex-math></inline-formula> DP-MIMO communication is also demonstrated with two 5G new radio 64-QAM uplink streams. Thanks to the proposed area-efficient bi-directional technique, the required core area for a single element-beamformer is only 0.58 mm 2 . Compact and low-cost 5G millimeter-wave MIMO systems could be realized.
The terdiurnal tide (TDT) in the Antarctic mesosphere and lower thermosphere region is poorly known. This study examines TDT using neutral wind observations at Syowa during years of 2004–2018. TDT is ...found to be a significant tidal component with distinct vertical structures and seasonal evolution. (1) It shows a prominent height‐dependent seasonal variation with phase reversal at 94 km. (2) The vertical wavelength in summer is ∼40 km shorter than in winter. These features differ largely from those in the Arctic, indicating hemispheric asymmetry. The phase structure reveals a dominant upward propagating mode in local summer but superposition of more than one mode in other seasons. A downward propagating mode above 94 km in winter suggests Joule heating/ion drag as additional tidal sources to lower atmosphere ones. These results provide new constrains and benchmarks for model simulations that seek to understand terdiurnal tidal forcing mechanisms in polar regions.
Plain Language Summary
Terdiurnal tides in the Antarctica mesosphere and lower thermosphere region are poorly known. In this study, we examine its characteristics using long‐term neutral wind observations at Syowa (69°S, 39°E) between January 2004 and July 2018. The analysis reveals terdiurnal tide being a significant tidal component in the Antarctica around solstices with distinct vertical structures. (1) Tides above 94 km has opposite climatological variation to that below 94 km. (2) The zonal and meridional wind components are 90° phase shifted, with similar amplitude in most seasons. (3) The vertical wavelength is shorter in summer than in winter. Most of these features differ from those reported in the Arctic, indicating hemispheric asymmetry. Furthermore, the phase structure reveals a dominant upward propagating mode in local summer but superposition of more than one mode in other seasons. A downward propagating mode in winter above 95 km suggests Joule heating/ion drag as likely tidal sources from above, in addition to those from lower atmosphere. The nearly 15‐year Syowa observations provide new constrains and benchmark for models that seek to understand terdiurnal tidal forcing mechanisms in polar regions.
Key Points
Terdiurnal tide is a significant tidal component around solstices
Upward propagating mode dominates in summer, with shorter vertical wavelength than in winter
Downward propagating mode above 94 km in winter suggests Joule heating/ion drag as likely tidal sources from above
The quantification of electroencephalography (EEG) microstates is an effective method for analyzing synchronous neural firing and assessing the temporal dynamics of the resting state of the human ...brain. Transcranial photobiomodulation (tPBM) is a safe and effective modality to improve human cognition. However, it is unclear how prefrontal tPBM neuromodulates EEG microstates both temporally and spectrally.
64-channel EEG was recorded from 45 healthy subjects in both 8-min active and sham tPBM sessions, using a 1064-nm laser applied to the right forehead of the subjects. After EEG data preprocessing, time-domain EEG microstate analysis was performed to obtain four microstate classes for both tPBM and sham sessions throughout the pre-, during-, and post-stimulation periods, followed by extraction of the respective microstate parameters. Moreover, frequency-domain analysis was performed by combining multivariate empirical mode decomposition with the Hilbert-Huang transform.
Statistical analyses revealed that tPBM resulted in (1) a significant increase in the occurrence of microstates A and D and a significant decrease in the contribution of microstate C, (2) a substantial increase in the transition probabilities between microstates A and D, and (3) a substantial increase in the alpha power of microstate D.
These findings confirm the neurophysiological effects of tPBM on EEG microstates of the resting brain, particularly in class D, which represents brain activation across the frontal and parietal regions. This study helps to better understand tPBM-induced dynamic alterations in EEG microstates that may be linked to the tPBM mechanism of action for the enhancement of human cognition.
This paper presents a low-power low-noise 60 GHz frequency synthesizer using a 20 GHz subsampling phase-locked loop (SS-PLL) and a 60 GHz tail-coupling quadrature injection-locked oscillator (QILO) ...which results in a lower in-band phase noise and out-of-band phase noise, respectively. To save battery life, dual-step-mixing injection-locked frequency divider (ILFD) enhances locking range for high division ratio. Moreover, tail cross-coupling technique in a QILO helps boost negative transconductance (-g m ) of the 60 GHz QILO which allows the use of larger inductance for power reduction. Implemented in 65 nm CMOS, it can cover required channels from 58.32 to 64.80 GHz with quadrature outputs. It consumes 24.2 and 7.8 mW from 20 GHz SS-PLL and QILO, respectively. The proposed synthesizer achieves -78.5; dBc/Hz at 100 kHz offset, -122 dBc/Hz at 10 MHz offset, and a figure-of-merit (FoM) of -236 dB.
Alzheimer's disease (AD) is a neurodegenerative disease and the world's primary cause of dementia, a condition characterized by significant progressive declines in memory and intellectual capacities. ...While dementia is the main symptom of Alzheimer's, the disease presents with many other debilitating symptoms, and currently, there is no known treatment exists to stop its irreversible progression or cure the disease. Photobiomodulation has emerged as a very promising treatment for improving brain function, using light in the range from red to the near-infrared spectrum depending on the application, tissue penetration, and density of the target area. The goal of this comprehensive review is to discuss the most recent achievements in and mechanisms of AD pathogenesis with respect to neurodegeneration. It also provides an overview of the mechanisms of photobiomodulation associated with AD pathology and the benefits of transcranial near-infrared light treatment as a potential therapeutic solution. This review also discusses the older reports and hypotheses associated with the development of AD, as well as some other approved AD drugs.
One of the main challenges in functional diffuse optical tomography (DOT) is to accurately recover the depth of brain activation, which is even more essential when differentiating true brain signals ...from task-evoked artifacts in the scalp. Recently, we developed a depth-compensated algorithm (DCA) to minimize the depth localization error in DOT. However, the semi-infinite model that was used in DCA deviated significantly from the realistic human head anatomy. In the present work, we incorporated depth-compensated DOT (DC-DOT) with a standard anatomical atlas of human head. Computer simulations and human measurements of sensorimotor activation were conducted to examine and prove the depth specificity and quantification accuracy of brain atlas-based DC-DOT. In addition, node-wise statistical analysis based on the general linear model (GLM) was also implemented and performed in this study, showing the robustness of DC-DOT that can accurately identify brain activation at the correct depth for functional brain imaging, even when co-existing with superficial artifacts.
•A brain atlas-based, depth-compensated diffuse optical tomography is developed.•DC-DOT is able to specify the deep brain activation from the superficial artifacts.•Volumetric DC-DOT image series is analyzed based on node-wise general linear model.
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