Hypoxia development in tumor is closely associated with its increased aggressiveness and strong resistance to therapy, leading to the poor prognosis in several cancer types. Clinically, invasive ...oxygen microelectrode and high dosage radiotherapy are often utilized to accurately detect and effectively fight hypoxia. Recently, however, there has been a surge of interdisciplinary research aiming at developing functional molecules and nanomaterials that can be used to noninvasively image and efficiently treat hypoxic tumors. In this review, we will provide an overview of the reports published to date on the imaging and therapy of hypoxic tumors. First, we will present the design concepts and engineering of various hypoxia-responsive probes that can be applied to image hypoxia noninvasively, in an order of fluorescent imaging, positron emission tomography, magnetic resonance imaging, and photoacoustic imaging. Then, we will summarize the up-to-date functional nanomaterials which can be used for the effective treatments of tumor hypoxia. The well-established chemical functions of these elaborately designed nanostructures will enable clinicians to adopt specific treatment concepts by overcoming or even utilizing hypoxia. Finally, challenges and future perspectives facing the researchers in the field will be discussed.
•PCM is a solution to reduce energy consumption and greenhouse gas emissions.•Evaluating the techniques used for the addition of nanoparticles to PCMs.•Discussing on effects of nanoparticles on the ...thermophysical properties of PCMs.•Examining the applications of nano-PCMs.•Phase change rate increases with the addition of nanoparticles.
Energy conservation management using latent heat storage (LHS) technique is nowadays employed as a solution to reduce energy consumption and greenhouse gas emissions. Phase change materials (PCMs) are the main candidate for LHS method. The main focus of this study is to evaluate the techniques used for the addition of nanoparticles to PCMs. The present paper is divided into three parts. The first part summarizes PCMs and nanoparticles. In the second part, the effects of nanoparticles on the most important thermophysical properties of PCMs are discussed. In the third part, the applications of nano-PCMs (NPCMs) in the fields such as thermal energy storage (TES), thermal control unit (TCU), photovoltaicthermal (PVT), solar still (SS) and building are examined. In general, all studies show that the phase change rate increases with the addition of nanoparticles. This means that the amount of energy stored/released during the phase change process is improved.
Crowdsourcing systems which utilize the human intelligence to solve complex tasks have gained considerable interest and adoption in recent years. However, the majority of existing crowdsourcing ...systems rely on central servers, which are subject to the weaknesses of traditional trust-based model, such as single point of failure. They are also vulnerable to distributed denial of service (DDoS) and Sybil attacks due to malicious users involvement. In addition, high service fees from the crowdsourcing platform may hinder the development of crowdsourcing. How to address these potential issues has both research and substantial value. In this paper, we conceptualize a blockchain-based decentralized framework for crowdsourcing named CrowdBC, in which a requester's task can be solved by a crowd of workers without relying on any third trusted institution, users’ privacy can be guaranteed and only low transaction fees are required. In particular, we introduce the architecture of our proposed framework, based on which we give a concrete scheme. We further implement a software prototype on Ethereum public test network with real-world dataset. Experiment results show the feasibility, usability, and scalability of our proposed crowdsourcing system.
In this work, we rationally designed a series of crystalline and stable dioxin‐linked metallophthalocyanine covalent organic frameworks (COFs; MPc‐TFPN COF, M=Ni, Co, Zn) under the guidance of ...reticular chemistry. As a novel single‐site catalysts (SSCs), NiPc/CoPc‐TFPN COF exhibited outstanding activity and selectivity for electrocatalytic CO2 reduction (ECR; Faradaic efficiency of CO (FECO)=99.8(±1.24) %/ 96.1(±1.25) % for NiPc/CoPc‐TFPN COF). More importantly, when coupled with light, the FECO and current density (jCO) were further improved across the applied potential range (−0.6 to −1.2 V vs. RHE) compared to the dark environment for NiPc‐TFPN COF (jCO increased from 14.1 to 17.5 A g−1 at −0.9 V; FECO reached up to ca. 100 % at −0.8 to −0.9 V). Furthermore, an in‐depth mechanism study was established by density functional theory (DFT) simulation and experimental characterization. For the first time, this work explored the application of COFs as photo‐coupled electrocatalysts to improve ECR efficiency, which showed the potential of using light‐sensitive COFs in the field of electrocatalysis.
A series of stable dioxin‐linked metallophthalocyanine covalent organic frameworks (COFs) were developed and applied for photo‐coupled electrocatalytic CO2 reduction. This work represents a new insight for the future rational design of light sensitive crystalline materials for CO2 reduction.
A strategy to covalently connect crystalline covalent organic frameworks (COFs) with semiconductors to create stable organic–inorganic Z‐scheme heterojunctions for artificial photosynthesis is ...presented. A series of COF–semiconductor Z‐scheme photocatalysts combining water‐oxidation semiconductors (TiO2, Bi2WO6, and α‐Fe2O3) with CO2 reduction COFs (COF‐316/318) was synthesized and exhibited high photocatalytic CO2‐to‐CO conversion efficiencies (up to 69.67 μmol g−1 h−1), with H2O as the electron donor in the gas–solid CO2 reduction, without additional photosensitizers and sacrificial agents. This is the first report of covalently bonded COF/inorganic‐semiconductor systems utilizing the Z‐scheme applied for artificial photosynthesis. Experiments and calculations confirmed efficient semiconductor‐to‐COF electron transfer by covalent coupling, resulting in electron accumulation in the cyano/pyridine moieties of the COF for CO2 reduction and holes in the semiconductor for H2O oxidation, thus mimicking natural photosynthesis.
Here comes the sun: A strategy to covalently connect covalent organic frameworks with semiconductors to create organic–inorganic Z‐scheme heterojunctions was developed and applied for the CO2 photoreduction with H2O. This work delivers new insights for the future design of Z‐scheme organic–inorganic heterojunctions for artificial photosynthesis.
Commercial advertisement (ad) dissemination has been proliferating on connected vehicles, allowing users to promote their products via vehicle-to-vehicle/-infrastructure communications. Despite the ...prospect of ad dissemination in vehicular networks, it faces challenges upon deployment especially on security and privacy. Particularly, vehicles may collude to defraud the advertiser to obtain rewards without disseminating ads, which may cause unfair "free-riding" issue in these activities. Furthermore, concerns on possible privacy leakage may discourage vehicles to participate in the process of ad dissemination. In addition, external DDoS attacks and internal single point of failure may also affect service availability. To address these issues, we explore the potential of blockchain technology to construct a fair and anonymous scheme for advertising in vehicular networks. We first present the overview of the blockchain-based ad dissemination framework. Then, under the framework, we design a concrete, fair and anonymous scheme. To ensure fairness, we utilize the Merkle hash tree together with smart contracts to achieve the "proof-of-ad-receiving" property (i.e., check whether a vehicle indeed receives an ad without deception or introducing significant storage cost) to mitigate the "free-riding" attack. On the other hand, any ad receiver who acquires a dissemination reward per ad more than once can be effectively detected and will be punished which is achieved by using smart contracts. Additionally, the proposed scheme can protect vehicles' privacy in terms of anonymity and conditional linkability based on zero-knowledge proof techniques. Lastly, extensive security analysis and implementations demonstrate the feasibility and efficiency of the scheme.
Recent years have seen a considerable growth of research interests in developing novel technologies that permit designable manufacture and controllable manipulation of actuators. Among various ...fabrication and driving strategies, light has emerged as an enabler to reach this end, contributing to the development of actuators. Several accessible light‐mediated manufacturing technologies, such as ultraviolet (UV) lithography and direct laser writing (DLW), are summarized. A series of light‐driven strategies including optical trapping, photochemical actuation, and photothermal actuation for controllable manipulation of actuators is introduced. Current challenges and future perspectives of this field are discussed. To generalize, light holds great promise for the development of actuators.
Recent advances in light‐mediated manufacture and manipulation of actuators are highlighted. Several optical fabrication technologies, including UV lithography and direct laser writing, and various photo‐driven strategies, such as optical trapping, and photochemical and photothermal actuation are reviewed. Emerging trends and future perspectives of light‐enabled actuators are discussed.
Hybrid-nanofluids are potential fluids that present superior thermophysical properties and thermal performance than common heat transfer fluids mono-nanofluids. Hybrid nanofluid is a new fluid ...produced by dispersing two dissimilar types of nano-particles into the base fluid. Some researchers have reported that conventional coolants could be replaced by hybrid-nanofluids, particularly fluids that work at very high temperatures. Accordingly, these types of nanofluids could lead to saving energy as well as less harmful environmental impacts. Many researches have been performed on nanofluids in the past decade. Despite the uncertainties in the nanofluids thermal-conductivity, they are still considered as heat transfer fluids with a new technology. In recent years, researchers have been trying to utilize hybrid-nanofluids designed by mixing different nanofluids in mixtures or composite forms. The idea of hybrid-nanofluids to improve heat transfer performance and their advantages has led to relatively good expectations for their applications. This article evaluates recent researches on hybrid-nanofluids, including methods of fabrication, thermophysical properties, nano-particle types and their shapes, pressure drop and heat transfer characteristics, and their applications. Finally, the challenges, environmental and destructive effects of nano-particles on the human body and future approaches in the application of hybrid-nanofluids in heat transfer devices are discussed.
Noise is usually undesired yet inevitable in science and engineering. However, by introducing the engineered noise to the precise solution of Jones matrix elements, we break the fundamental limit of ...polarization multiplexing capacity of metasurfaces that roots from the dimension constraints of the Jones matrix. We experimentally demonstrate up to 11 independent holographic images using a single metasurface illuminated by visible light with different polarizations. To the best of our knowledge, it is the highest capacity reported for polarization multiplexing. Combining the position multiplexing scheme, the metasurface can generate 36 distinct images, forming a holographic keyboard pattern. This discovery implies a new paradigm for high-capacity optical display, information encryption, and data storage.
Next generation theranostic devices will rely on the smart integration of different functional moieties into one system. These individual chemical elements will have a variety of desired chemical and ...physical properties and will need to behave in a multifunctional manner. Researchers have used upconversion nanoparticles (UCNPs) as a basis for superior imaging probes to locate cancerous lesions. The features of these nanoparticles, such as large anti-Stokes shifts, sharp emission bands, long-lived luminescence, and high resistance to photobleaching, have produced versatile probes. One way to improve these probes is to add a layer of dense or mesoporous silica to the outer surface of UCNPs (UCNP@SiO2). These modified UCNPs are chemically stable and much less cytotoxic than the original UCNPs. In addition, their surface can be easily modified to introduce various functional groups (e.g., −NH2, −COOH, −SH) via silanization, which facilitates conjugations with various biological molecules for multimodal imaging or synergetic therapeutics. This versatility makes UCNP@SiO2 particles excellent platforms for the construction of efficient theranostics. In this Account, we provide a comprehensive summary of recent progress in the development of UCNP@SiO2 nanocomposites for theranostics in the hope of speeding their translation into the clinic. We first discuss the major design principles and protocols for engineering various nanocomposites based on UCNP@SiO2 structures including those coated with dense silica, mesoporous silica, or hollow mesoporous silica. Next we summarize several representative efforts that probe the relaxivity mechanisms of these nanostructures as a way to optimize magnetic resonance sensitivity, multimode cancer imaging, near-infrared light-triggered chemotherapy, photodynamic therapy, and synergetic therapy (the combination of radiotherapy with chemotherapy, thermotherapy, or photodynamic therapy) using UCNP@SiO2-based theranostics. By rational integration of a wide range of features that convey multiple functions (such as imaging and therapy) into the structure or onto the surfaces of UCNP@SiO2, the constructed theranostics show promise for multimodal cancer imaging, biosensing, and effective cancer therapy. Finally, we discuss the limitations of UCNP@SiO2 nanostructures, the difficulties in the design of smart theranostics, and their potential role in clinical cancer research.
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