Regression analysis is to establish the regression relationship between dependent variables and independent variables. The data of traditional regression model are often assumed to be observed ...precisely. However this assumption holds only sometimes. Due to the influence of various uncertain factors, the data in reality is often inaccurate. Therefore, We treat real data as uncertain variables. Uncertain regression analysis is likely to provide an effective analysis method. Based on the uncertainty theory, the residual analysis of verhulst-pearl model is discussed in this paper. We use the least square method to estimate the parameters. And we also obtained the confidence interval of the response variables for the new explanatory variables. In the uncertain regression analysis, we propose a leave-<inline-formula> <tex-math notation="LaTeX">p </tex-math></inline-formula>-out cross-validation method for model selection under imprecise observation. We end up the paper with a numerical example of uncertain Verhulst-Pearl regression model and show that the model has a better prediction accuracy.
Wood-based products manufactured from fast-growing wood species such as eucalyptus have gained increasing attraction with the demand of using wood in architecture, furniture, and decoration. In this ...paper, a new type of wood scrimber based on eucalyptus veneers complexed with ferrous ions was prepared and its properties were characterized. The results showed that the presence of complexes did not affect the mechanical properties of eucalyptus wood scrimber, but made its surface more hydrophobic (contact angle increased by 38.48% and dimensional stability improved (thickness swelling rate decreased by 32.26%). Most importantly, the color of eucalyptus wood scrimber changed significantly, from the original brown to dark blue, and its anti-photoaging property also greatly improved. These advantages would make this type of wood scrimber based on the eucalyptus veneer complexes with ferrous ions more widely applicable in decorations and buildings.
Uncertain differential equations (UDEs) with jumps are an essential tool to model the dynamic uncertain systems with dramatic changes. The interest rates, impacted heavily by human uncertainty, are ...assumed to follow UDEs with jumps in ideal markets. Based on this assumption, two derivatives, namely, interest-rate caps (IRCs) and interest-rate floors (IRFs), are investigated. Some formulas are presented to calculate their prices, which are of too complex forms for calculation in practice. For this reason, numerical algorithms are designed by using the formulas in order to compute the prices of these structured products. Numerical experiments are performed to illustrate the effectiveness and efficiency, which also show the prices of IRCs are strictly increasing with respect to the diffusion parameter while the prices of IRFs are strictly decreasing with respect to the diffusion parameter.
We propose and numerically demonstrate a secure optical communication scheme in a small-world semiconductor lasers network based on cluster chaos synchronization and false-message scrambling. ...According to the symmetries of network, the semiconductor lasers are divided into sets of heterogeneous coupled clusters. The properties of cluster chaos synchronization, the performance and security of optical chaotic communication, as well as the influence of false message on the synchronization of clusters are systematically investigated. It is demonstrated that, by properly setting the parameters of the lasers network, high-quality chaos synchronization can be achieved between the intra-cluster lasers, whereas incoherent states are observed between inter-cluster lasers. Moreover, by inserting false messages into the inter-cluster couplings, the privacy of chaotic carriers transmitted over the inter-cluster public links can be significantly enhanced, as such secure bidirectional communication among intra-cluster lasers is achievable with a message bit rate of several Gbit/s. Compared with the conventional point-to-point communication systems, the proposed scheme supports multipoint-to-multipoint secure communications.
This Series on urban design, transport, and health aimed to facilitate development of a global system of health-related policy and spatial indicators to assess achievements and deficiencies in urban ...and transport policies and features. This final paper in the Series summarises key findings, considers what to do next, and outlines urgent key actions. Our study of 25 cities in 19 countries found that, despite many well intentioned policies, few cities had measurable standards and policy targets to achieve healthy and sustainable cities. Available standards and targets were often insufficient to promote health and wellbeing, and health-supportive urban design and transport features were often inadequate or inequitably distributed. City planning decisions affect human and planetary health and amplify city vulnerabilities, as the COVID-19 pandemic has highlighted. Hence, we offer an expanded framework of pathways through which city planning affects health, incorporating 11 integrated urban system policies and 11 integrated urban and transport interventions addressing current and emerging issues. Our call to action recommends widespread uptake and further development of our methods and open-source tools to create upstream policy and spatial indicators to benchmark and track progress; unmask spatial inequities; inform interventions and investments; and accelerate transitions to net zero, healthy, and sustainable cities.
Abstract
Rapid advances in flexible and wearable smart textiles demand low-cost, high-energy/power-density fiber-shaped supercapacitors (FSCs). The performance of FSCs is determined by the ...fabrication and assembly of fiber-shaped electrodes (FSEs), where an active charge-storage material is always clad around flexible charge transmission current collectors. Inspired by the tissue structure of natural bamboo, wherein parenchyma cells (PCs) that store nutrients are clad around bamboo fibers (BFs), we propose a strategy for converting bamboo cells into FSEs using conductive BFs and activated PCs as current collectors and active materials, respectively. The assembled electrode has a high specific capacitance of 1454 mF cm
−2
at 0.64 mA cm
−2
. A solid-state FSC with a pair of bamboo-structured electrodes exhibited a substantially high energy density. Its mechanical flexibility enabled the knitting of wearable wristbands to drive ultra-small voltmeter indicators. This lightweight, low cost, and high-energy-density bamboo-structured FSC could enable numerous smart textile applications.
Abstract
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of prostate cancer that rarely develops de novo in primary tumors and is commonly acquired during the development of treatment ...resistance. NEPC is characterized by gain of neuroendocrine markers and loss of androgen receptor (AR), making it resistant to current therapeutic strategies targeting the AR signaling axis. Here, we report that MCM2, MCM3, MCM4, and MCM6 (MCM2/3/4/6) are elevated in human NEPC and high levels of MCM2/3/4/6 are associated with liver metastasis and poor survival in prostate cancer patients. MCM2/3/4/6 are four out of six proteins that form a core DNA helicase (MCM2-7) responsible for unwinding DNA forks during DNA replication. Inhibition of MCM2-7 by treatment with ciprofloxacin inhibits NEPC cell proliferation and migration in vitro, significantly delays NEPC tumor xenograft growth, and partially reverses the neuroendocrine phenotype in vivo. Our study reveals the clinical relevance of MCM2/3/4/6 proteins in NEPC and suggests that inhibition of MCM2-7 may represent a new therapeutic strategy for NEPC.
Peri-menopausal syndrome (PMPS) has a high incidence rate and seriously affects the physical and mental health of women. Honghua Xiaoyao Pill (HHXYP) is a Chinese patent medicine, which has been ...reported to be used to treat PMPS. However, there is still a lack of randomized clinical trial to evaluate the efficacy and safety of HHXYP on life quality, mood and vasomotor symptoms for PMPS women. This study aims to investigate whether HHXYP is effective and safe in treating PMPS and the possible mechanism.
A multicenter, randomized, controlled clinical trial will be conducted in China to evaluate the efficacy and safety of HHXYP. Sixty women with peri-menopausal syndrome will be recruited at three centers and randomly in a 1:1 ratio to a treatment group using HHXYP (HHXYP group) and a control group using oryzanol (OC group). Participants will be treated with HHXYP or oryzanol for 12 weeks and followed up for 4 weeks. The primary outcome is the modified Kupperman Index (KI), which will be measured at baseline and 4, 8, 12, 16 weeks after randomization. The secondary outcomes include Hot flash scale (HFs), Menopause-Specific Quality of Life Scale (MENQOL) and Hamilton Depression/Anxiety Scale (HAMD/HAMA). The HFs are measured at the same point as the KI, other secondary outcomes are measured at baseline and 12, 16 weeks after randomization. The other outcomes are the levels of serum sex hormone, monoamine neurotransmitter, vascular vasomotor factor and the expression of phosphatidylinositol 3-active enzyme (PI3K)/protein activator enzyme B (Akt), which will be measured at baseline and 12 weeks after randomization. Adverse events will also be reported.
HHXYP is a potential alternative Chinese patent medicine for PMPS. This trial will provide evidence for HHXYP on improving the quality of life, mood and vasomotor symptoms, and sex hormone levels of PMPS patients.
BRCA1 deficient breast cancers are aggressive and chemoresistant due, in part, to their enrichment of cancer stem cells that can be generated from carcinoma cells by an epithelial-mesenchymal ...transition (EMT). We previously discovered that BRCA1 deficiency activates EMT in mammary tumorigenesis. How BRCA1 controls EMT and how to effectively target BRCA1-deficient cancers remain elusive. We analyzed murine and human tumors and identified a role for Tgfβr2 in governing the molecular aspects of EMT that occur with Brca1 loss. We utilized CRISPR to delete Tgfβr2 and specific inhibitors to block Tgfβr2 activity and followed up with the molecular analysis of assays for tumor growth and metastasis. We discovered that heterozygous germline deletion, or epithelia-specific deletion of Brca1 in mice, activates Tgfβr2 signaling pathways in mammary tumors. BRCA1 depletion promotes TGFβ-mediated EMT activation in cancer cells. BRCA1 binds to the TGFβR2 locus to repress its transcription. Targeted deletion or pharmaceutical inhibition of Tgfβr2 in Brca1-deficient tumor cells reduces EMT and suppresses tumorigenesis and metastasis. BRCA1 and TGFβR2 expression levels are inversely related in human breast cancers. This study reveals for the first time that a targetable TGFβR signaling pathway is directly activated by BRCA1-deficiency in the induction of EMT in breast cancer progression.
Lysine crotonylation has attracted widespread attention in recent years. However, little is known about bacterial crotonylation, particularly crotonyltransferase and decrotonylase, and its effects on ...antibiotic resistance. Our study demonstrates the ubiquitous presence of crotonylation in E. coli, which promotes bacterial resistance to polymyxin. We identify the crotonyltransferase YjgM and its regulatory pathways in E. coli with a focus on crotonylation. Further studies show that YjgM upregulates the crotonylation of the substrate protein PmrA, thereby boosting PmrA’s affinity for binding to the promoter of eptA, which, in turn, promotes EptA expression and confers polymyxin resistance in E. coli. Additionally, we discover that PmrA’s crucial crotonylation site and functional site is Lys 164. These significant discoveries highlight the role of crotonylation in bacterial drug resistance and offer a fresh perspective on creating antibacterial compounds.
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•YjgM functions as a crotonyltransferase in Escherichia coli•Crotonylation proteomics reveals differentially crotonylated proteins in PMB-R•YjgM promotes bacterial polymyxin resistance via the crotonylation of PmrA•Crotonylation promotes PmrA’s binding ability to the eptA promoter
Zhuang et al. find that YjgM is a crotonyltransferase in Escherichia coli. YjgM improves the binding affinity between the polymyxin-resistant protein PmrA and the eptA promoter by increasing the crotonoylation level of PmrA, thereby encouraging the expression of eptA, resulting in the development of polymyxin resistance in E. coli.
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