By designing a structured gas density profile between the dual-stage gas jets to manipulate electron seeding and energy chirp reversal for compressing the energy spread, we have experimentally ...produced high-brightness high-energy electron beams from a cascaded laser wakefield accelerator with peak energies in the range of 200-600 MeV, 0.4%-1.2% rms energy spread, 10-80 pC charge, and ∼0.2 mrad rms divergence. The maximum six-dimensional brightness B_{6D,n} is estimated as ∼6.5×10^{15} A/m^{2}/0.1%, which is very close to the typical brightness of e beams from state-of-the-art linac drivers. These high-brightness high-energy e beams may lead to the realization of compact monoenergetic gamma-ray and intense coherent x-ray radiation sources.
Soil acidification is a major problem in soils of intensive Chinese agricultural systems. We used two nationwide surveys, paired comparisons in numerous individual sites, and several long-term ...monitoring-field data sets to evaluate changes in soil acidity. Soil pH declined significantly (P < 0.001) from the 1980s to the 2000s in the major Chinese crop-production areas. Processes related to nitrogen cycling released 20 to 221 kilomoles of hydrogen ion (H⁺) per hectare per year, and base cations uptake contributed a further 15 to 20 kilomoles of H⁺ per hectare per year to soil acidification in four widespread cropping systems. In comparison, acid deposition (0.4 to 2.0 kilomoles of H⁺ per hectare per year) made a small contribution to the acidification of agricultural soils across China.
Despite the importance of decision-making (DM) techniques for construction of effective decision models for supplier selection, there is a lack of a systematic literature review for it. This paper ...provides a systematic literature review on articles published from 2008 to 2012 on the application of DM techniques for supplier selection. By using a methodological decision analysis in four aspects including decision problems, decision makers, decision environments, and decision approaches, we finally selected and reviewed 123 journal articles. To examine the research trend on uncertain supplier selection, these articles are roughly classified into seven categories according to different uncertainties. Under such classification framework, 26 DM techniques are identified from three perspectives: (1) Multicriteria decision making (MCDM) techniques, (2) Mathematical programming (MP) techniques, and (3) Artificial intelligence (AI) techniques. We reviewed each of the 26 techniques and analyzed the means of integrating these techniques for supplier selection. Our survey provides the recommendation for future research and facilitates knowledge accumulation and creation concerning the application of DM techniques in supplier selection.
Whole Atmosphere Community Climate Model (WACCM) simulations are used to investigate solar and lunar tide changes in the mesosphere and lower thermosphere (MLT) that occur in response to sudden ...stratosphere warmings (SSWs). The average tidal response is demonstrated based on 23 moderate to strong Northern Hemisphere SSWs. The migrating semidiurnal lunar tide is enhanced globally during SSWs, with the largest enhancements (∼60–70%) occurring at mid to high latitudes in the Northern Hemisphere. Enhancements in the migrating solar semidiurnal tide (SW2) also occur up to an altitude of 120 km. Above this altitude, the SW2 decreases in response to SSWs. The SW2 enhancements are 40–50%, making them smaller in a relative sense than the enhancements in the migrating semidiurnal lunar tide. Changes in nonmigrating solar tides are, on average, generally small and the only nonmigrating tides that exhibit changes greater than 20% are the diurnal tide with zonal wave number 0 (D0) and the westward propagating semidiurnal tide with zonal wave number 1 (SW1). D0 is decreased by ∼20–30% at low latitudes, while SW1 exhibits a similar magnitude enhancement at mid to high latitudes in both hemispheres. The tidal changes are attributed to a combination of changes in the zonal mean zonal winds, changes in ozone forcing of the SW2, and nonlinear planetary wave‐tide interactions. We further investigate the influence of the lunar tide enhancements on generating perturbations in the low latitude ionosphere during SSWs by using the WACCM‐X thermosphere to drive an ionosphere‐electrodynamics model. For both solar maximum and solar minimum simulations, the changes in the equatorial vertical plasma drift velocity are similar to observations when the lunar tide is included in the simulations. However, when the lunar tide is removed from the simulations, the low latitude ionosphere response to SSWs is unclear and the characteristic behavior of the low latitude ionosphere perturbations that is seen in observations is no longer apparent. Our results thus indicate the importance of variability in the lunar tide during SSWs, especially for the coupling between SSWs and perturbations in the low latitude ionosphere.
Key Points
Investigate tidal variability due to SSWs based on WACCM simulations of 23 SSWs
Large changes in the migrating semidiurnal lunar and solar tides during SSWs
Changes in lunar tide are important for coupling between SSWs and ionosphere
Face-centered cubic (fcc) HEAs, particularly the typical FeCoNiCrMn HEA, are promising for cryogenic applications but generally exhibit relatively low strength at ambient temperature, which limits ...their widespread uses. In this work, we present a systematic study of enhancing simultaneously the strength and ductility of FeCoNiCrMn HEAs via tailoring the phase stability and stacking fault energy (SFE). It was found that in Fe20CoxNi40-xCr20Mn20 (x = 20–30 at.%) HEAs, with the increase of Co, the SFE was gradually decreased and another hcp (hexagonal close-packed) phase was eventually formed in the alloy containing 28 at.% Co. As a result, the deformation mode changes from dislocation glide to mechanical twinning, then to γfcc → εhcp martensitic transformation. Our analysis indicates that the small critical shear stress for twinning resulted from the reduced SFE provides a steady strain hardening rate in a wide strain regime and postpones the plastic instability, eventually leading to the concurrent enhancement in the tensile strength and ductility. Our results not only shed lights on understanding of the effects of SFE on the mechanical properties, but also have important implications on the development of HEAs with a unique combination of high strength and large ductility.
•Increase of the Co content decreases the SFE and phase stability of FeCoNiCrMn alloy.•TRIP effects were achieved with the increase of Co content.•Increase of Co enhances the strength and ductility simultaneously.•Effects of the SFE on deformation mechanism were explored.
Intracellular pH (pHi) is an important parameter associated with cellular behaviors and pathological conditions. Sensing pHi and monitoring its changes in live cells are essential but challenging due ...to the lack of effective probes. We herein report a pH-sensitive fluorogen for pHi sensing and tracking. The dye is a tetraphenylethene–cyanine adduct (TPE-Cy). It is biocompatible and cell-permeable. Upon diffusing into cells, it responds sensitively to pHi in the entire physiological range, visualizing the acidic and basic compartments with intense red and blue emissions, respectively. The ratiometric signal of the red and blue channels can thus serve as an indicator for local proton concentration. The utility of TPE-Cy in pHi imaging and monitoring is demonstrated with the use of confocal microscopy, ratiometric analysis, and flow cytometry.
Recent developments in the instrumentation and data analysis of synchrotron small‐angle X‐ray scattering (SAXS) on biomolecules in solution have made biological SAXS (BioSAXS) a mature and popular ...tool in structural biology. This article reports on an advanced endstation developed at beamline 13A of the 3.0 GeV Taiwan Photon Source for biological small‐ and wide‐angle X‐ray scattering (SAXS–WAXS or SWAXS). The endstation features an in‐vacuum SWAXS detection system comprising two mobile area detectors (Eiger X 9M/1M) and an online size‐exclusion chromatography system incorporating several optical probes including a UV–Vis absorption spectrometer and refractometer. The instrumentation and automation allow simultaneous SAXS–WAXS data collection and data reduction for high‐throughput biomolecular conformation and composition determinations. The performance of the endstation is illustrated with the SWAXS data collected for several model proteins in solution, covering a scattering vector magnitude q across three orders of magnitude. The crystal‐model fittings to the data in the q range ∼0.005–2.0 Å−1 indicate high similarity of the solution structures of the proteins to their crystalline forms, except for some subtle hydration‐dependent local details. These results open up new horizons of SWAXS in studying correlated local and global structures of biomolecules in solution.
A new endstation for biological small‐ and wide‐angle X‐ray scattering is detailed, which provides development opportunities for studying correlated local and global structures of biomolecules in solution.
•Prevailing C&D waste quantification methodologies are identified and compared.•One specific methodology cannot fulfill all waste quantification scenarios.•A relevance tree for appropriate ...quantification methodology selection is proposed.•More attentions should be paid to civil and infrastructural works.•Classified information is suggested for making an effective waste management plan.
Quantifying construction and demolition (C&D) waste generation is regarded as a prerequisite for the implementation of successful waste management. In literature, various methods have been employed to quantify the C&D waste generation at both regional and project levels. However, an integrated review that systemically describes and analyses all the existing methods has yet to be conducted. To bridge this research gap, an analytical review is conducted. Fifty-seven papers are retrieved based on a set of rigorous procedures. The characteristics of the selected papers are classified according to the following criteria - waste generation activity, estimation level and quantification methodology. Six categories of existing C&D waste quantification methodologies are identified, including site visit method, waste generation rate method, lifetime analysis method, classification system accumulation method, variables modelling method and other particular methods. A critical comparison of the identified methods is given according to their characteristics and implementation constraints. Moreover, a decision tree is proposed for aiding the selection of the most appropriate quantification method in different scenarios. Based on the analytical review, limitations of previous studies and recommendations of potential future research directions are further suggested.
With the increasing use of magnetic resonance imaging (MRI) in the evaluation of children with endocrine disorders, pituitary stalk thickening (PST) poses a clinical conundrum due to the potential ...for underlying neoplasms and challenges in obtaining a tissue biopsy. The existing literature suggests Langerhans cell histiocytosis (LCH) to be the commonest (16%) oncologic cause for PST, followed by germ cell tumors (GCTs, 13%) (CCLG 2021). As the cancer epidemiology varies according to ethnicity, we present herein the incidence and predictors for oncologic etiologies in Hong Kong Chinese children with PST.
Based on a territory-wide electronic database, we reviewed patients aged < 19 years who presented to three referral centers with endocrinopathies between 2010 and 2022. Records for patients who underwent at least one MRI brain/pituitary were examined (
= 1670): those with PST (stalk thickness ≥ 3 mm) were included, while patients with pre-existing cancer, other CNS and extra-CNS disease foci that were diagnostic of the underlying condition were excluded.
Twenty-eight patients (M:F = 10:18) were identified. The median age at diagnosis of PST was 10.9 years (range: 3.8-16.5), with central diabetes insipidus (CDI) and growth hormone deficiency (GHD) being the most frequent presenting endocrine disorders. At a median follow-up of 4.8 years, oncologic diagnoses were made in 14 patients (50%), including 13 GCTs (46%; germinoma = 11, non-germinoma = 2) and one LCH (4%). Among patients with GCTs, 10 were diagnosed based on histology, two by abnormal tumor markers and one by a combination of histology and tumor markers. Three patients with germinoma were initially misdiagnosed as hypophysitis/LCH. The cumulative incidence of oncologic diagnoses was significantly higher in boys and patients with PST at presentation ≥6.5 mm, CDI or ≥2 pituitary hormone deficiencies at presentation and evolving hypopituitarism (all
< 0.05 by log-rank).
A higher rate of GCTs was observed in Chinese children with endocrinopathy and isolated PST. The predictors identified in this study may guide healthcare providers in Asia in clinical decision making. Serial measurement of tumor markers is essential in management.
We report on near-GeV electron beam generation from an all-optical cascaded laser wakefield accelerator (LWFA). Electron injection and acceleration are successfully separated and controlled in ...different LWFA stages by employing two gas cells filled with a He/O2 mixture and pure He gas, respectively. Electrons with a Maxwellian spectrum, generated from the first LWFA assisted by ionization-induced injection, were seeded into the second LWFA with a 3-mm-thick gas cell and accelerated to be a 0.8-GeV quasimonoenergetic electron beam, corresponding to an acceleration gradient of 187 GV/m. The demonstrated scheme paves the way towards the multi-GeV laser accelerators.
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