Effetto della razza, dell'ordine di parto e dello stadio di lattazione sul contenuto di acido linoleico coniugato nel grasso del latte di bovine Frisone e Reggiane - Sono stati raccolti campioni di ...latte individuali con cadenza mensile da 22 vacche di razza Frisona Italiana e 24 vacche di razza Reggiana, mantenute nello stesso allevamento dal parto fino al settimo mese di lattazione, al fine di stimare l'effetto della razza, dell'ordine di parto e dello stadio di lattazione sul contenuto di acido linoleico coniugato (CLA) e di altri acidi grassi a media e lunga catena nel grasso del latte. Il contenuto di CLA non è risultato influenzabile né dalla razza né dall'ordine di parto, ma è variato sensibilmente nel corso della lattazione, evidenziando un aumento del 50% fra il primo e il settimo controllo. All'inizio della lattazione la sintesi degli acidi grassi a media catena è risultata inibita dalla maggior presenza di acido oleico e acido stearico.
Understanding the functional consequences of genetic variation, and how it affects complex human disease and quantitative traits, remains a critical challenge for biomedicine. We present an analysis ...of RNA sequencing data from 1641 samples across 43 tissues from 175 individuals, generated as part of the pilot phase of the Genotype-Tissue Expression (GTEx) project. We describe the landscape of gene expression across tissues, catalog thousands of tissue-specific and shared regulatory expression quantitative trait loci (eQTL) variants, describe complex network relationships, and identify signals from genome-wide association studies explained by eQTLs. These findings provide a systematic understanding of the cellular and biological consequences of human genetic variation and of the heterogeneity of such effects among a diverse set of human tissues.
To evaluate the use of 3.0 T MRI in the prognosis of inferior alveolar nerve (IAN) sensory disorders after mandibular third molar extraction, in the early post-operative period.
343 IANs were ...examined before and 3 days after surgery. Two radiologists evaluated the course of the nerve and the relative signal intensity (RSI). Cohen's kappa coefficient (κ) and intraclass correlation coefficient (ICC) were used to evaluate the interobserver (k = 0.891) and intra-observer variability (ICC = 0.927; 0.914, respectively). The IANs were divided into four groups on the basis of neurosensory disorders recovery time. ANOVA was used to evaluate the differences among the RSIs of the four groups, and multiple comparisons were performed with Tukey's range test.
No differences in the course of IANs were found before and after surgery. In 280 IANs, no iatrogenic paraesthesia was found (Group A). 63 IANs showed a neurosensory impairment. 38 IANs showed recovery of post-operative paraesthesia at 3-month follow-up (Group B). 16 IANs showed a full recovery of iatrogenic paraesthesia at 6-month follow-up (Group C). Seven IANs displayed a full recovery at 12-month follow-up and two IANs showed persistence of neurosensory disorders at 18-month follow-up (Group D). The one-way ANOVA results indicated statistically significant difference among all groups (p < 0.05), except between Groups C and D (p = 0.504).
The early evaluation of RSI values represents a valid tool to determine the prognosis of IAN sensory disorders after mandibular third molar extraction.
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