As low‐dimensional lead‐free hybrids with higher stability and lower toxicity than those of three‐dimensional lead perovskites, organic antimony(III) halides show great application potential in ...opt‐electronic field owing to diverse topologies along with exceptional optical properties. We report herein an antimony(III) hybrid (MePPh3)2SbCl5 with a zero‐dimensional (0D) structure, which exhibits brilliant orange emission peaked at 593 nm with near‐unity photoluminescent quantum yield (99.4 %). The characterization of photophysical properties demonstrates that the broadband emission with a microsecond lifetime (3.24 μs) arises from self‐trapped emission (STE). Electrically driven organic light‐emitting diodes (OLEDs) based on neat and doped films of (MePPh3)2SbCl5 were fabricated. The doped devices show significant improvement in comparison to non‐doped OLEDs. Owing to the much improved surface morphology and balanced carrier transport in light‐emitting layers of doped devices, the peak luminance, current efficiency (CE) and external quantum efficiency (EQE) are boosted from 82 cd m−2 to 3500 cd m−2, 1.1 cd A−1 to 6.8 cd A−1, and 0.7 % to 3.1 % relative to non‐doped devices, respectively.
A highly luminescent organic antimony(III) hybrid (MePPh3)2SbCl5 featured with STE emission is prepared with good reproducibility and high stability. High‐efficiency OLEDs are demonstrated with this hybrid as an emitter with the luminance of 3500 cd m−2, current efficiency of 6.8 cd A−1 and EQE of 3.1 %, respectively.
A trace (BINAP)2Cu2Br2-doped TPP3CuBr complex TPP3CuBr:x(BINAP)2Cu2Br2 (complex 1) was synthesized, which exhibits strong phosphorescence with a yellow-green emission peak at 525 nm and a shoulder ...peak at 560 nm. Nevertheless, no emissions were observed for either pure (BINAP)2Cu2Br2 or pure TPP3CuBr. The plausible mechanism is that the incorporation of (BINAP)2Cu2Br2 into the rigid environment provided by the TPP3CuBr matrix effectively restricts the variation of (BINAP)2Cu2Br2 molecules, thus reducing nonradiative transitions. On the other hand, π–π stacking and hydrogen bond interactions may influence the conformation of (BINAP)2Cu2Br2, potentially leading to more efficient phosphorescence. Interestingly, complex 1 was found to have a sensitive response to dichloromethane (DCM) solvent. An obvious blue shift in emission was observed when complex 1 was exposed to a DCM atmosphere. Moreover, after removal from the DCM atmosphere, complex 1 can be restored to its initial state. Additionally, complex 1 demonstrated remarkable attributes, including high sensitivity, selectivity, and stability.
As low‐dimensional lead‐free hybrids with higher stability and lower toxicity than those of three‐dimensional lead perovskites, organic antimony(III) halides show great application potential in ...opt‐electronic field owing to diverse topologies along with exceptional optical properties. We report herein an antimony(III) hybrid (MePPh3)2SbCl5 with a zero‐dimensional (0D) structure, which exhibits brilliant orange emission peaked at 593 nm with near‐unity photoluminescent quantum yield (99.4 %). The characterization of photophysical properties demonstrates that the broadband emission with a microsecond lifetime (3.24 μs) arises from self‐trapped emission (STE). Electrically driven organic light‐emitting diodes (OLEDs) based on neat and doped films of (MePPh3)2SbCl5 were fabricated. The doped devices show significant improvement in comparison to non‐doped OLEDs. Owing to the much improved surface morphology and balanced carrier transport in light‐emitting layers of doped devices, the peak luminance, current efficiency (CE) and external quantum efficiency (EQE) are boosted from 82 cd m−2 to 3500 cd m−2, 1.1 cd A−1 to 6.8 cd A−1, and 0.7 % to 3.1 % relative to non‐doped devices, respectively.
A highly luminescent organic antimony(III) hybrid (MePPh3)2SbCl5 featured with STE emission is prepared with good reproducibility and high stability. High‐efficiency OLEDs are demonstrated by this hybrid as an emitter with the luminance of 3500 cd m−2, current efficiency of 6.8 cd A−1 and EQE of 3.1 %, respectively.
AIM: To explore the probable pathway by which curcumin(Cur) regulates the function of Treg cells by observing the expression of costimulatory molecules of dendritic cells(DCs).METHODS: Experimental ...colitis was induced by administering 2, 4, 6-trinitrobenzene sulfonic acid(TNBS)/ethanol solution. Forty male C57BL/6 mice were randomly divided into four groups: normal, TNBS + Cur, TNBS + mesalazine(Mes) and TNBS groups. The mice in the TNBS + Cur and TNBS +Mes groups were treated with Cur and Mes, respectively, while those in the TNBS group were treated with physiological saline for 7 d. After treatment, the curative effect of Cur was evaluated by colonic weight, colonic length, weight index of the colon, and histological observation and score. The levels of CD4+CD25+Foxp3+ T cells(Treg cells) and costimulatory molecules of DCs were measured by flow cytometry. Also, related cytokines were analyzed by enzyme-linked immunosorbent assay. RESULTS: Cur alleviated inflammatory injury of the colonic mucosa, decreased colonic weigh and histological score, and restored colonic length. The number of Treg cells was increased, while the secretion of TNF-α, IL-2, IL-6, IL-12 p40, IL-17 and IL-21 and the expression of costimulatory molecules(CD205, CD54 ICAM-1, TLR4, CD252OX40 L, CD256 RANK and CD254 RANK L) of DCs were notably inhibited in colitis mice treated with Cur.CONCLUSION: Cur potentially modulates activation of DCs to enhance the suppressive functions of Treg cells and promote the recovery of damaged colonic mucosa in inflammatory bowel disease.
Histone deacetylase 6 (HDAC6) has been considered as an important regulator in the development of inflammatory diseases. However, the mechanism of HDAC6 in regulating inflammatory responses has not ...been fully determined. In the present study, we aim to investigate the role and mechanisms of HDAC6 in regulating inflammation in lipopolysaccharide (LPS)-activated macrophages.
Flow cytometry was used to determine a suitable treatment dosage of ACY-1215 on lipopolysaccharide (LPS)-activated macrophages for the present study. The RAW264.7 macrophages were divided into normal, LPS-treated, and ACY-1215 treated groups, respectively. For the ACY-1215 group, ACY-1215 (10 μM) was added to the medium 2 h prior to treatment with LPS (1 μg/ml) for 24 h. In this study, ROS, inflammatory cytokines, the ultrastructure of mitochondria, mitochondrial membrane potential, RNA and protein expression assay were detected respectively. Subsequently, the effect of HDAC6 knockdown on inflammatory response in LPS-activated RAW264.7 macrophages was also detected.
Inhibition of HDAC6 inhibited the overproduction of ROS and suppressed the expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 in LPS-activated RAW264.7 cells. Pretreatment with ACY-1215 could normalize the ultrastructure of mitochondria and mitochondrial membrane potential in LPS-activated macrophages. Moreover, the protein expression of TLR4, Nrf2, HO-1 and the activation of MAPK and NF-κB signaling pathways were normalized by the inhibition of HDAC6.
Inhibition of HDAC6 exhibited protective role against LPS-induced inflammation in RAW264.7 cells by regulating oxidative stress and suppressing the activation of TLR4- MAPK/NF-κB signaling pathway.
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