"The International Conferences on Economics and Social Sciences (ICESS)organized by Bucharest University of Economic Studies provide an opportunity for all those interested in Economics and Social ...Sciences to discuss and exchange research ideas. The papers presented at the Conference are available online in the Conference Proceedings series (ISSN 2704-6524): Volume 2019 Collaborative Research for Excellence in Economics and Social Sciences, ISBN 9788366675322 Volume 2020 Innovative Models to Revive the Global Economy, ISBN 9788395815072 Volume 2021 Resilience and Economic Intelligence Through Digitalization and Big Data Analytics, ISBN 9788366675704 During 2020, leaders found themselves at a historic crossroads, taking decisions under remarkable pressures and uncertainties. However, windows of opportunity are being created to shape the economic recovery, restore the health of the environment, develop sustainable business models, strengthen regional development, revitalize global cooperation, harness Industry 4.0, and redesign the social contracts, skills, and jobs. This conference provides an opportunity for all those interested in Economics and Social Sciences to discuss and exchange research ideas especially in the light of recent crisis determined by COVID-19. We welcome both empirical and theoretical work that is broadly consistent with the conference’ general theme. Especially, researchers, PhD students and practitioners are invited to submit papers on the topics related to new models in entrepreneurship and innovation, sustainability and education, data science and digitalization, marketing and finance etc. that will develop innovative instruments for countries, businesses and education to revive after the crisis."
Background: Since 1999 the Romanian health insurance system shifts to aBismarckmodel where primary care is provided by family medicine physicians, in private practices, under contract with local ...insurance houses. Family doctors are supposed to have a Gatekeeping role, ensuring that patients see specialists only for conditions that could not be managed at this level and are referred to an appropriate specialist. Aims: To explore the opinions of the family doctors on the interventions needed for a better management of the psychiatric cases. Method: A survey was conducted among 43 family doctors fromGalaticounty (Romania). Results and Discussion: Despite a formal gatekeeping role, Romanian family doctors do not have a pivotal role in coordinating psychiatric care. Direct access to a specialist is possible for certain pathologies and there is evidence of overuse of ambulance services, hospital services and outpatient care setting bypassing primary care. Conclusion: Rather than focusing on the “gatekeeping” we should focus on more collaborative work between family doctors and psychiatrists with patients. An improved communication and cooperation between the family doctor and the psychiatrist plays an essential role for proper care processes and thus the overall quality of care for the psychiatric patient.
Psychiatric Drugs and Antibiotics. When Two Worlds Collide Alina Pleșea-Condratovici; Simona Lungu; Mihai Mutică ...
Brain. Broad research in artificial intelligence and neuroscience,
06/2019, Letnik:
10, Številka:
Special Issue on Psychiatry
Journal Article
Recenzirano
Odprti dostop
Background: Both psychotropic medication and antibiotic therapy are extensively prescribed. In many cases, these medications are concurrent and the necessity to analyze this particular drug ...interaction appears. Aims: To identify in specialized medical databases what these interactions are, which is their biochemical substrate, and which is the optimal method to avoid unwanted drug associations. Method: Abstracts of PubMed database were automatically filtered using a specific search tool, the keyword data being drug interactions psychotropics, antibiotics and their synonyms, and websites dedicated to drug interactions were interrogated on the same subject. Results and Discussion: Given that there is not enough clear data, especially for new developed medicines, it seems that drug interactions between antibiotics and psychotropic drugs are generally benign. Even if specialized web applications to identify drug interactions already exist, their results often differ or are not consistent. Conclusion: Although interactions between psychotropic and antibiotic drugs appear to be generally benign, more valid data are needed to properly assess their impact on treatment efficiency and the patient’s quality of life. Antibiotics must be prescribed when necessary and it is advisable to avoid antibiotic classes with the most documented drug interactions: Fluoroquinolones, Macrolides and Anti-tuberculosis drugs.
The excavations conducted in August - September 2006, aimed to excavating the first Getic level. All the three complexes investigated in 2006 delivered a considerable quantity of archaeological ...material consisting mostly of pottery, animal bones and metal fragments. We cleared the older sections carried out in the ‘80s of the past century with a view to resuming the archaeological excavations in the years to come.
We report here the design, synthesis, experimental and in silico evaluation of the antibacterial and antifungal activity of some new benzofquinoline derivatives. Two classes of benzofquinolinium ...derivatives-(benzofquinolinium salts (
) and pyrrolobenzofquinolinium cycloadducts (
)-were designed and obtained in two steps via a direct and facile procedure: quaternization followed by a cycloaddition reaction. The synthesized compounds were characterized by elemental and spectral analysis (FT-IR,
H-NMR,
C-NMR). The antimicrobial assay reveals that the
salts have an excellent quasi-nonselective antifungal activity against the fungus
(some of them higher that the control drug nystatin) and very good antibacterial activity against the Gram positive bacterium
. The
compounds are inactive. Analysis of the biological data reveals interesting SAR correlations in the benzofquinolinium series of compounds. The in silico studies furnished important data concerning the pharmacodynamics, pharmacokinetics and ADMET parameters of the
salts. Studies of the interaction of each
salt
with ATP synthase in the formed complex, reveal that salts
,
and
have the best fit in a complex with ATP synthase. Study of the interaction of each
salt
with TOPO II in the formed complex reveals that salts
and
have the best-fit in complex with TOPO II. The in silico ADMET studies reveal that the
salts have excellent drug-like properties, including a low toxicity profile. Overall, the experimental and in silico studies indicate that compounds
and
(from the aliphatic series), respectively, and
,
and
(from the aromatic series), are promising leading drug candidates.
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