Abstract The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological ...characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.
The hydrogen isotope value (δD) of water indigenous to the mantle is masked by the early degassing and recycling of surface water through Earth's history. High 3He/4He ratios in some ocean island ...basalts, however, provide a clear geochemical signature of deep, primordial mantle that has been isolated within the Earth's interior from melting, degassing, and convective mixing with the upper mantle. Hydrogen isotopes were measured in high 3He/4He submarine basalt glasses from the Southeast Indian Ridge (SEIR) at the Amsterdam–St. Paul (ASP) Plateau (δD = −51 to −90‰, 3He/4He = 7.6 to 14.1 RA) and in submarine glasses from Loihi seamount south of the island of Hawaii (δD = −70 to −90‰, 3He/4He = 22.5 to 27.8 RA). These results highlight two contrasting patterns of δD for high 3He/4He lavas: one trend toward high δD of approximately −50‰, and another converging at δD = −75‰. These same patterns are evident in a global compilation of previously reported δD and 3He/4He results. We suggest that the high δD values result from water recycled during subduction that is carried into the source region of mantle plumes at the core–mantle boundary where it is mixed with primordial mantle, resulting in high δD and moderately high 3He/4He. Conversely, lower δD values of −75‰, in basalts from Loihi seamount and also trace element depleted mid-ocean ridge basalts, imply a primordial Earth hydrogen isotopic value of −75‰ or lower. δD values down to −100‰ also occur in the most trace element-depleted mid-ocean ridge basalts, typically in association with 87Sr/86Sr ratios near 0.703. These lower δD values may be a result of multi-stage melting history of the upper mantle where minor D/H fractionation could be associated with hydrogen retention in nominally anhydrous residual minerals. Collectively, the predominance of δD around −75‰ in the majority of mid-ocean ridge basalts and in high 3He/4He Loihi basalts is consistent with an origin of water on Earth that was dominated by accretion of chondritic material.
•δD determined on submarine glasses from Loihi and Amsterdam–St. Paul hotspots.•Primordial δD = −75‰ characterized by Loihi glasses with 3He/4He = 20–30 RA.•Amsterdam–St. Paul δD trends towards −50‰ from mixing with recycled water.•Low δD values globally of −90 to −100‰ often found in ultra-depleted fracture zones.•Global δD variations explained as mixing between these endmember components.
We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium ...(ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).
ABSTRACT
We present measurements of galaxy clustering from the Baryon Oscillation Spectroscopic Survey (BOSS), which is part of the Sloan Digital Sky Survey III (SDSS‐III). These use the Data Release ...9 (DR9) CMASS sample, which contains 264 283 massive galaxies covering 3275 square degrees with an effective redshift z = 0.57 and redshift range 0.43 < z < 0.7. Assuming a concordance ΛCDM cosmological model, this sample covers an effective volume of 2.2 Gpc3, and represents the largest sample of the Universe ever surveyed at this density, n¯≈3×10−4h−3 Mpc 3. We measure the angle‐averaged galaxy correlation function and power spectrum, including density‐field reconstruction of the baryon acoustic oscillation (BAO) feature. The acoustic features are detected at a significance of 5σ in both the correlation function and power spectrum. Combining with the SDSS‐II luminous red galaxy sample, the detection significance increases to 6.7σ. Fitting for the position of the acoustic features measures the distance to z = 0.57 relative to the sound horizon DV/rs = 13.67 ± 0.22 at z = 0.57. Assuming a fiducial sound horizon of 153.19 Mpc, which matches cosmic microwave background constraints, this corresponds to a distance DV (z = 0.57) = 2094 ± 34 Mpc. At 1.7 per cent, this is the most precise distance constraint ever obtained from a galaxy survey. We place this result alongside previous BAO measurements in a cosmological distance ladder and find excellent agreement with the current supernova measurements. We use these distance measurements to constrain various cosmological models, finding continuing support for a flat Universe with a cosmological constant.
In 2013, high-temperature vent fluids were sampled in the Nifonea vent field. This field is located within the caldera of a large shield-type volcano of the Vate Trough, a young extensional rift in ...the New Hebrides back-arc. Hydrothermal venting occurs as clear and black smoker fluids with temperatures up to 368°C, the hottest temperatures measured so far in the western Pacific.
The physico-chemical conditions place the fluids within the two-phase field of NaCl–H2O, and venting is dominated by vapour phase fluids with Cl concentrations as low as 25mM. The fluid composition, which differs between the individual vent sites, is interpreted to reflect the specific geochemical fluid signature of a hydrothermal system in its initial, post-eruptive stage. The strong Cl depletion is accompanied by low alkali/Cl ratios compared to more evolved hydrothermal systems, and very high Fe/Cl ratios. The concentrations of REY (180nM) and As (21μM) in the most Cl-depleted fluid are among the highest reported so far for submarine hydrothermal fluids, whereas the inter-element REY fractionation is only minor.
The fluid signature, which has been described here for the first time in a back-arc setting, is controlled by fast fluid passage through basaltic volcanic rocks, with extremely high water-rock ratios and only limited water-rock exchange, phase separation and segregation, and (at least) two-component fluid mixing. Metals and metalloids are unexpectedly mobile in the vapour phase fluids, and the strong enrichments of Fe, REY, and As highlight the metal transport capacity of low-salinity, low-density vapours at the specific physico-chemical conditions at Nifonea. One possible scenario is that the fluids boiled before the separated vapour phase continued to react with fresh glassy lavas. The mobilization of metals is likely to occur by leaching from fresh glass and grain boundaries and is supported by the high water/rock ratios. The enrichment of B and As is further controlled by their high volatility, whereas the strong enrichment of REY is also a consequence of the elevated concentrations in the host rocks. However, a direct contribution of metals such as As from magmatic degassing cannot be ruled out. The different fluid end-member composition of individual vent sites could be explained by mixing of vapour phase fluids with another fluid phase of different water/rock interaction history.
Exploring the Submarine Ring of Fire EMBLEY, ROBERT W.; BAKER, EDWARD T.; BUTTERFIELD, DAVID A. ...
Oceanography (Washington, D.C.),
12/2007, Letnik:
20, Številka:
4
Journal Article
Recenzirano
Odprti dostop
Sampling an erupting volcano at 550-m depth, discovering roiling pools of liquid sulfur at 400-m depth, watching tropical fish swimming amid fields of black smoker vents, and encountering a blizzard ...of liquid carbon dioxide globules rising from fractured lava flows at 1600-m depth all sound like wishful thinking or scenes from a science fiction movie. But, we had the good fortune to observe these and other previously unseen phenomena between 2004 and 2006 during a series of expeditions to the Mariana arc in the western Pacific. We describe here several of the most interesting sites, along with their geologic and oceanographic contexts.
This study compared knowledge attainment and student enjoyment and engagement between clinical case vignette, patient-testimony videos and mixed reality (MR) teaching via the Microsoft HoloLens 2, ...all delivered remotely to third year medical students. The feasibility of conducting MR teaching on a large scale was also assessed.
Medical students in Year 3 at Imperial College London participated in three online teaching sessions, one in each format. All students were expected to attend these scheduled teaching sessions and to complete the formative assessment. Inclusion of their data used as part of the research trial was optional.
The primary outcome measure was performance on a formative assessment, which served to compare knowledge attainment between three forms of online learning. Moreover, we aimed to explore student engagement with each form of learning via a questionnaire, and also feasibility of applying MR as a teaching tool on a large scale. Comparisons between performances on the formative assessment between the three groups were investigated using a repeated measures two-way ANOVA. Engagement and enjoyment were also analysed in the same manner.
A total of 252 students participated in the study. Knowledge attainment of students using MR was comparable with the other two methods. Participants reported higher enjoyment and engagement (p<0.001) for the case vignette method, compared with MR and video-based teaching. There was no difference in enjoyment or engagement ratings between MR and the video-based methods.
This study demonstrated that the implementation of MR is an effective, acceptable, and feasible way of teaching clinical medicine to undergraduate students on a large scale. However, case-based tutorials were found to be favoured most by students. Future work could further explore the best uses for MR teaching within the medical curriculum.
Adaptive optics (AO) is a technology that corrects in real time for the blurring effects of atmospheric turbulence, in principle allowing Earth‐bound telescopes to achieve their diffraction limit and ...to “see” as clearly as if they were in space. The power of AO using natural guide stars has been amply demonstrated in recent years on telescopes up to 3–4 m in diameter. The next breakthrough in astronomical resolution was expected to occur with the implementation of AO on the new generation of large, 8–10 m diameter telescopes. In this paper we report the initial results from the first of these AO systems, now coming on line on the 10 m diameter Keck II Telescope. The results include the highest angular resolution images ever obtained from a single telescope (0
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040 at 0.85 and 1.65 μm wavelengths, respectively), as well as tests of system performance on three astronomical targets.
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