Abstract
Asteroseismology is playing an increasingly important role in the characterization of red giant host stars and their planetary systems. Here, we conduct detailed asteroseismic modeling of ...the evolved red giant branch (RGB) hosts KOI-3886 and
ι
Draconis, making use of end-of-mission Kepler (KOI-3886) and multisector TESS (
ι
Draconis) time-series photometry. We also model the benchmark star KIC 8410637, a member of an eclipsing binary, thus providing a direct test to the seismic determination. We test the impact of adopting different sets of observed modes as seismic constraints. Inclusion of
ℓ
= 1 and 2 modes improves the precision of the stellar parameters, albeit marginally, compared to adopting radial modes alone, with 1.9%–3.0% (radius), 5%–9% (mass), and 19%–25% (age) reached when using all
p
-dominated modes as constraints. Given the very small spacing of adjacent dipole mixed modes in evolved RGB stars, the sparse set of observed
g
-dominated modes is not able to provide extra constraints, further leading to highly multimodal posteriors. Access to multiyear time-series photometry does not improve matters, with detailed modeling of evolved RGB stars based on (lower-resolution) TESS data sets attaining a precision commensurate with that based on end-of-mission Kepler data. Furthermore, we test the impact of varying the atmospheric boundary condition in our stellar models. We find the mass and radius estimates to be insensitive to the description of the near-surface layers, at the expense of substantially changing both the near-surface structure of the best-fitting models and the values of associated parameters like the initial helium abundance,
Y
i
. Attempts to measure
Y
i
from seismic modeling of red giants may thus be systematically dependent on the choice of atmospheric physics.
Cryogels exhibit unique shape memory with full recovery and structural stability features after multiple injections. These constructs also possess enhanced cell permeability and nutrient diffusion ...when compared to typical bulk hydrogels. Volumetric processing of cryogels functionalized with nanosized units has potential to widen their biomedical applications, however this has remained challenging and relatively underexplored. In this study, we report a novel methodology that combines suspension 3D printing with directional freezing for the fabrication of nanocomposite cryogels with configurable anisotropy. When compared to conventional bulk or freeze-dried hydrogels, nanocomposite cryogel formulations exhibit excellent shape recovery (>95%) and higher pore connectivity. Suspension printing, assisted with a prechilled metal grid, was optimized to induce anisotropy. The addition of calcium- and phosphate-doped mesoporous silica nanoparticles into the cryogel matrix enhanced bioactivity toward orthopedic applications without hindering the printing process. Notably, the nanocomposite 3D printed cryogels exhibit injectable shape memory while also featuring a lamellar topography. The fabrication of these constructs was highly reproducible and exhibited potential for a cell-delivery injectable cryogel with no cytotoxicity to human-derived adipose stem cells. Hence, in this work, it was possible to combine a gravity defying 3D printed methodology with injectable and controlled anisotropic macroporous structures containing bioactive nanoparticles. This methodology ameliorates highly tunable injectable 3D printed anisotropic nanocomposite cryogels with a user-programmable degree of structural complexity.
After the serendipitous discovery of cisplatin, a platinum-based drug with chemotherapeutic effects, an incredible amount of research in the area of coordination chemistry has been produced. Other ...transition metal compounds were studied, and several new relevant metallodrugs have been synthetized in the past few years. This review is focused on coordination compounds with first-row transition metals, namely, copper, cobalt, nickel or manganese, or with zinc, which have potential or effective pharmacological properties. It is known that metal complexes, once bound to organic drugs, can enhance the drugs' biological activities, such as anticancer, antimicrobial or anti-inflammatory ones. NSAIDs are a class of compounds with anti-inflammatory properties used to treat pain or fever. NSAIDs' properties can be strongly improved when included in complexes using their compositional N and O donor atoms, which facilitate their coordination to metal ions. This review focuses on the research on this topic and on the promising or effective results that complexes of first-row transition metals and NSAIDs can exhibit.
16 Cyg A and B are among the brightest stars observed by Kepler. What makes these stars more interesting is that they are solar analogs. 16 Cyg A and B exhibit solar-like oscillations. In this work ...we use oscillation frequencies obtained using 2.5 yr of Kepler data to determine the current helium abundance of these stars. For this we use the fact that the helium ionization zone leaves a signature on the oscillation frequencies and that this signature can be calibrated to determine the helium abundance of that layer. By calibrating the signature of the helium ionization zone against models of known helium abundance, the helium abundance in the envelope of 16 Cyg A is found to lie in the range of 0.231 to 0.251 and that of 16 Cyg B lies in the range of 0.218 to 0.266.
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•Leishmania infantum genomes were compared according their temporal isolation.•Asymptomatic L. infantum Isolates are less diverse than the symptomatic ones.•Chromosome somy varies ...dramatically amongst the different genomes.•At least two populations of L. infantum are circulating in northeastern Brazil.
The genomic sequences of 20 Leishmania infantum isolates collected in northeastern Brazil were compared with each other and with the available genomic sequences of 29 L. infantum/donovani isolates from Nepal and Turkey. The Brazilian isolates were obtained in the early 1990s or since 2009 from patients with visceral or non-ulcerating cutaneous leishmaniasis, asymptomatic humans, or dogs with visceral leishmaniasis. Two isolates were from the blood and bone marrow of the same visceral leishmaniasis patient. All 20 genomic sequences display 99.95% identity with each other and slightly less identity with a reference L. infantum genome from a Spanish isolate. Despite the high identity, analysis of individual differences among the 32 million base pair genomes showed sufficient variation to allow the isolates to be clustered based on the primary sequence. A major source of variation detected was in chromosome somy, with only four of the 36 chromosomes being predominantly disomic in all 49 isolates examined. In contrast, chromosome 31 was predominantly tetrasomic/pentasomic, consistent with its regions of synteny on two different disomic chromosomes of Trypanosoma brucei. In the Brazilian isolates, evidence for recombination was detected in 27 of the 36 chromosomes. Clustering analyses suggested two populations, in which two of the five older isolates from the 1990s clustered with a majority of recent isolates. Overall the analyses do not suggest individual sequence variants account for differences in clinical outcome or adaptation to different hosts. For the first known time, DNA of isolates from asymptomatic subjects were sequenced. Of interest, these displayed lower diversity than isolates from symptomatic subjects, an observation that deserves further investigation with additional isolates from asymptomatic subjects.
The Vista Variables in the Via Lactea (VVV) survey has allowed for an unprecedented number of multi-epoch observations of the southern Galactic plane. In a recent paper, 13 massive young stellar ...objects (MYSOs) have already been identified within the highly variable (ΔKs > 1 mag) YSO sample of another published work. This study aims to understand the general nature of variability in MYSOs. Here we present the first systematic study of variability in a large sample of candidate MYSOs. We examined the data for variability of the putative driving sources of all known Spitzer extended green objects (EGOs; 270) and bright 24 μm sources coinciding with the peak of 870 μm detected ATLASGAL clumps (448), a total of 718 targets. Of these, 190 point sources (139 EGOs and 51 non-EGOs) displayed variability (IQR > 0.05, ΔKs > 0.15 mag). 111 and 79 light-curves were classified as periodic and aperiodic respectively. Light-curves have been sub-classified into eruptive, dipper, fader, short-term-variable and long-period-variable-YSO categories. Lomb-Scargle periodogram analysis of periodic light-curves was carried out. 1–870 μm spectral energy distributions of all the variable sources were fitted with YSO models to obtain the representative properties of the variable sources. 41% of the variable sources are represented by > 4 M⊙ objects, and only 6% were modelled as > 8 M⊙ objects. The highest-mass objects are mostly non-EGOs, and deeply embedded, as indicated by nearly twice the extinction when compared with EGO sources. By placing them on the HR diagram we show that most of the lower mass, EGO type objects are concentrated on the putative birth-line position, while the luminous non-EGO type objects group around the zero-age-main-sequence track. Some of the most luminous far infrared (FIR) sources in the massive clumps and infrared quiet driving sources of EGOs have been missed out by this study owing to an uniform sample selection method. A high rate of detectable variability in EGO targets (139 out of 153 searched) implies that near-infrared variability in MYSOs is closely linked to the accretion phenomenon and outflow activity.
The stratification near the base of the Sun's convective envelope is governed by processes of convective overshooting and element diffusion, and the region is widely believed to play a key role in ...the solar dynamo. The stratification in that region gives rise to a characteristic signal in the frequencies of solar p modes, which has been used to determine the depth of the solar convection zone and to investigate the extent of convective overshoot. Previous helioseismic investigations have shown that the Sun's spherically symmetric stratification in this region is smoother than that in a standard solar model without overshooting, and have ruled out simple models incorporating overshooting, which extend the region of adiabatic stratification and have a more-or-less abrupt transition to subadiabatic stratification at the edge of the overshoot region. In this paper we consider physically motivated models which have a smooth transition in stratification bridging the region from the lower convection zone to the radiative interior beneath. We find that such a model is in better agreement with the helioseismic data than a standard solar model.
In addition to its search for extrasolar planets, the NASA Kepler mission provides exquisite data on stellar oscillations. We report the detections of oscillations in 500 solar-type stars in the ...Kepler field of view, an ensemble that is large enough to allow statistical studies of intrinsic stellar properties (such as mass, radius, and age) and to test theories of stellar evolution. We find that the distribution of observed masses of these stars shows intriguing differences to predictions from models of synthetic stellar populations in the Galaxy.
Abstract Cowpea (Vigna unguiculata (L.) Walp.) is a legume widely cultivated by small, medium and large producers in several Brazilian regions. However, one of the concerns for the production of ...cowpea in Brazil in recent years is the low rainfall activity in these regions, which generates the accumulation of salts on the surface. The objective of this work was to evaluate the effects of salt stress on growth parameters and enzyme activity in cowpea plants at different concentrations of brassinosteroids. Experiment was developed in a greenhouse using a completely randomized experimental design in a 3 x 3 factorial scheme. The treatments consisted of three levels of brassinosteroids (0, 3 and 6 µM EBL) and three levels of salt stress (0, 50 and 100 mM NaCl). Growth factors (height, diameter and number of leaves) decreased in the saline condition. With the presence of brassinosteroid the height did not increase, but the number of leaves did, mainly in the saline dosage of 100 mM NaCl. In the variable membrane integrity, brassinosteroid was efficient in both salinity dosages, the same not happening with the relative water content, where the saline condition did not affect the amount of water in the vegetable, with the application of brassino it remained high, decreasing only at dosage 100 mM NaCl. The nitrate reductase enzyme was greatly affected in the root system even with the application of increasing doses of brassino. Therefore, brassinosteroids as a promoter of saline tolerance in cowpea seedlings was positive. The concentration of 3µM of EBL provided the most satisfactory effect in tolerating the deleterious effects of the saline condition. The same cannot be concluded for the concentration of 6µM of EBL that did not promote tolerance to some variables.
Resumo O feijão-caupi (Vigna unguiculata (L.) Walp.) é uma leguminosa amplamente cultivada por pequenos, médios e grandes produtores em diversas regiões brasileiras. No entanto, uma das preocupações para a produção de feijão-caupi no Brasil nos últimos anos é a baixa atividade pluviométrica nessas regiões, o que gera o acúmulo de sais na superfície. O objetivo deste trabalho foi avaliar os efeitos do estresse salino nos parâmetros de crescimento e atividade enzimática em plantas de feijão-caupi em diferentes concentrações de brassinosteróides. O experimento foi desenvolvido em casa de vegetação com delineamento experimental inteiramente casualizado em esquema fatorial 3 x 3. Os tratamentos consistiram de três níveis de brassinosteróides (0, 3 e 6 µM EBL) e três níveis de estresse salino (0, 50 e 100 mM NaCl). Os fatores de crescimento (altura, diâmetro e número de folhas) diminuíram na condição salina. Com a presença do brassinosteroide a altura não aumentou, mas o número de folhas sim, principalmente na dosagem salina de 100 mM NaCl. Na variável integridade de membrana, o brassinosteróide foi eficiente em ambas as dosagens de salinidade, o mesmo não ocorrendo com o teor relativo de água, onde a condição salina não afetou a quantidade de água na hortaliça, com a aplicação de brassino manteve-se elevada, diminuindo apenas na dosagem de NaCl 100 mM. A enzima nitrato redutase foi bastante afetada no sistema radicular mesmo com a aplicação de doses crescentes de brassino. Portanto, o uso de brassinosteroides como promotor de tolerância salina em plântulas de feijão-caupi foi positivo. A concentração de 3µM de EBL proporcionou o efeito mais satisfatório em tolerar os efeitos deletérios da condição salina. O mesmo não pode ser concluído para a concentração de 6µM de EBL que não promoveu tolerância a algumas variáveis.
Water stress limits the initial growth and development of maize mass and grain, as well as the physiological process for absorbing the amount of mineral elements. The objective was to evaluate the ...effect of silicon on germination and growth of corn seedlings submitted to water deficit. The experiment was carried out in the laboratory and the experimental design was completely randomized (factorial 3 × 4), with three concentrations of calcium silicate (0.0; 1.0 and 2.0 mM) and 4 solutions of PEG-6000 to simulate different osmotic potentials (0, 0; -0.3; -0.6; -0.9 MPa). Germination percentage, germination speed index (GSI), mean germination time (MGT), percentage of non-germinated and abnormal germinated, length and dry matter of shoot, root and total seedlings were evaluated. Water deficiency reduced the parameters TG, GSI and MGT. The water deficit reduce the MSPA, MSR and MST with more than 80% reduction in mass from seedlings without deficiency to seedlings with deficiency. For CPA, CR and CT there was a reduction of at least 87%, 70% and 77%, respectively, among seeds without deficiency compared to seeds submitted to deficiency. The use of silicon in corn seeds did not attenuate the stress caused by water deficit simulated by PEG-6000.
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