We describe the growth and investigation of a novel type of structure in which self-organised InAs quantum dots are incorporated in the AlAs tunnelling barrier of an n-i-n single-barrier ...GaAs/AlAs/GaAs heterostructure. The lowtemperature current-voltage curves exhibit a series of pronounced peaks which are absent in a control sample grown without InAs in the barrier. By studying their behaviour in a magnetic field
B, we attribute these peaks to single-electron tunnelling through single discrete zero-dimensional states of individual InAs dots in the barrier.
OBJECTIVES: The economic burden of long term care for people with dementia is significant and substantially covered by state Medicaid programs. While no therapies exist to substantially alter disease ...progression, supportive services for caregivers have been shown to improve caregiver capabilities and well-being and delay patients' institutionalization. We estimated the potential cost savings from offering the New York University Caregiver Intervention (NYUCI) to eligible Medicaid enrollees from a state payer perspective. METHODS: Data from the Minnesota Department of Human Services and the literature informed a population-based Markov model to predict and compare costs, including intervention costs, over 15 years with and without implementation of the NYUCI for family caregivers of community-based Medicaid eligibles with dementia. We incorporated original NYUCI randomized controlled trial results as appropriate, adjusted to Minnesota implementation. RESULTS: Approximately 5-6% more eligibles with dementia would remain in the community from year 3 (2014) on and 17% fewer would die in nursing homes over 15 years if their caregivers received the NYUCI. The state could save $40.4 million (2011 dollars, discounted at 3%) if all eligibles/ caregivers participated in the NYUCI. Savings are expected within 5 years of program implementation. Best-and worst-case scenario estimates were $178.9 million and -$7.3 million, respectively, driven largely by the variation in the assumed NYUCI effect. CONCLUSIONS: State payers can use enhanced caregiver support to moderate the growing tax burden of dementia, even without a breakthrough in pharmacologic treatment of the disease. But because it takes time to realize savings from a program like the NYUCI, the frequently short time horizon of legislative fiscal notes presents a challenge to adoption. In deciding on program value it may be important to distinguish cost-effectiveness from return on investment and take long-term impact into consideration.
An abstract of a study by Figiel et al evaluating a treatment switch to rivastigmine in patients who were not responding adequately to or clinically declining on treatment with donepezil is ...presented. They conclude that switching patients from donepezil to rivastigmine is well-tolerated. Additionally, the results indicate that patients who were previously not responding adequately to donepezil either improved or stabilized after switching to rivastigmine treatment.
We show that the precise orientation of a C(60) molecule which terminates the tip of a scanning probe microscope can be determined with atomic precision from submolecular contrast images of the ...fullerene cage. A comparison of experimental scanning tunneling microscopy data with images simulated using computationally inexpensive Hückel theory provides a robust method of identifying molecular rotation and tilt at the end of the probe microscope tip. Noncontact atomic force microscopy resolves the atoms of the C(60) cage closest to the surface for a range of molecular orientations at tip-sample separations where the molecule-substrate interaction potential is weakly attractive. Measurements of the C(60)-C(60) pair potential acquired using a fullerene-terminated tip are in excellent agreement with theoretical predictions based on a pairwise summation of the van der Waals interactions between C atoms in each cage, i.e., the Girifalco potential L. Girifalco, J. Phys. Chem. 95, 5370 (1991).
The interstitial deletion of the short arm of chromosome (6)--46 XY del (6) (p22.3 p24) is unrecorded. The ophthalmic findings in a dysmorphic infant included peripheral sclerocornea and epicanthal ...folds with upslanting palpebral fissures. We present a short review of sclerocornea and the ophthalmic findings of infants with anomalies of chromosome 6. Our findings provide further evidence that genes influencing the development of the anterior segment are located on the distal portion of the short arm of chromosome 6.