Nasal mucosa (respiratory and olfactory) and lingual gingiva of the rabbit were depleted of their sympathetic nerves by superior cervical ganglionectomy. In the innervated nasal mucosa, exogenous ...tritiated norepinephrine (3H-NE) was metabolised mainly to tritiated 3,4-dihydroxyphenylethylene glycol (3HDOPEG) and 3,4-dihydroxy mandelic acid (3HDOMA), whereas after denervation it was metabolised mainly to tritiated normetanephrine (3HNMN). In the denervated mucosa, cocaine (30 umol/1) inhibited 3HNMN formation by 50-60%. Cocaine also inhibited 3HNMN formation by 60% in the denervated lingual gingiva. It is concluded that the tissues metabolise 3H-NE via a cocaine-sensitive extraneuronal uptake and O-methylating system similar to that which has been shown to be present in dental pulp.
Yes
Widespread generation and analysis of omics data have revolutionized molecular medicine on Earth, yet its power to yield new mechanistic insights and improve occupational health during ...spaceflight is still to be fully realized in humans. Nevertheless, rapid technological advancements and ever-regular spaceflight programs mean that longitudinal, standardized, and cost-effective collection of human space omics data are firmly within reach. Here, we consider the practicality and scientific return of different sampling methods and omic types in the context of human spaceflight. We also appraise ethical and legal considerations pertinent to omics data derived from European astronauts and spaceflight participants (SFPs). Ultimately, we propose that a routine omics collection program in spaceflight and analog environments presents a golden opportunity. Unlocking this bright future of artificial intelligence (AI)-driven analyses and personalized medicine approaches will require further investigation into best practices, including policy design and standardization of omics data, metadata, and sampling methods.
H.C., R.H., J.B., D.B., S.G., T.E., and N.J.S. are members of the ESA Space Omics Topical Team, funded by the ESA grant/contract 4000131202/20/NL/PG/pt “Space Omics: Towards an integrated ESA/NASA –omics database for spaceflight and ground facilities experiments” awarded to R.H., which was the main funding source for this work. H.C. is also supported by the Horizon Center for Doctoral Training at the University of Nottingham (UKRI grant no. EP/S023305/1). S.G. is supported by the Swedish Research Council VR grant 2020-04864. L.A.R. and M.M. represent the Omics Subgroup of the Japan Society for the Promotion of Science KAKENHI funding group “Living in Space” and are supported by JP15K21745, JP20H03234, and 20F20382. L.A.R. is also supported by the JSPS postdoctoral fellowship P20382. We thank Dr. Sarah Castro-Wallace, the NASA GeneLab Animal AWG, ISSOP, ESA Space Omics Topical Team, ESA Personalized Medicine Topical Team, and Global Alliance for Genomic Health (GA4GH) for useful discussions.
American Indian literary nationalism Weaver, Jace; Womack, Craig S; Warrior, Robert ...
Journal of American studies,
12/2007, Letnik:
41, Številka:
3
Book Review
Having spent all my spare time this year writing my own book from inside the arts world, I am looking forward to getting back to other people's books this summer. I will be delving with fascination ...into Peter Brook's memoir, Threads of Time (Methuen Drama, £17.99), the story of the various strands of his life, and his quest for a theatre that was "simple in form and rich in meaning". For relaxation, I will make my irregular pilgrimage into E.M. Forster's Howards End (Penguin Fiction, £5.99), that wonderful novel concerned with the attempt to reconcile the outer life with the life we all live on the inside. Books on the beach - and sand between the pages that inevitably and grittily gets itself back into villa or hotel. In one of my choices, some of the grit comes from the characters involved: women of excruciating emotional vulgarity who slide and rampage through Diana Souhami's Mrs (Flamingo, £7.99). I find it impossible to take any of the people involved seriously. Alice Keppel was mistress to Edward VII, a great charmer and a smooth operator. Her daughter Violet (not by the King) was consumed by a desperate passion for Vita Sackville-West. The ins-and-outs of their love affair, the hysterical flights, the pursuits by husbands, the dressing-up (Vita as "Julian", Violet as "Eve") and the stupefying selfishness and self-delusion by all concerned, is the Ring cycle scripted by Labiche. The author seems to find it rather touching. Don't you believe it! It is tearing farce, and should really bear the title of that Edwardian novel Round the Corner in Gay Street . In 1996, the physicist Alan Sokal published a paper on "transformative hermeneutics of quantum gravity" in Social Text, a journal of obscurantist metatwaddle. Though crammed with deliberate scientific blunders, the paper flattered the editors' views on "post- Enlightenment hegemony", and they fell for it. Sokal then revealed the hoax. Instead of conceding a fair cop - caught with their postmodern pants down - the editors pathetically cried foul, and l'affaire Sokal has been rumbling up and down the rive gauche and the internet ever since. Now, in collaboration with Jean Bricmont, Sokal has given us a devastating book, Intellectual Impostures (Profile, £9.99). Why care? Because, as Paul Gross and Norman Levitt documented in Higher Superstition (Johns Hopkins, £14), francophone charlatanry is influential far beyond French shores. Taken together, they imply that a disreputable, if not sinister, tendency has infected Anglo-American literary thought. They make fascinating, if chilling reading.
Reviews Dengate, R. Dale; Riddler, Eric; Potter, Miriam ...
Australian and New Zealand Journal of Art: the real millenium issue,
20/1/1/, Letnik:
2, Številka:
1
Book Review
