A review is presented of the history of the Point Defect Model (PDM) for the growth and breakdown of passive films that form on the surfaces of reactive metals in contact with corrosive, condensed ...phase environments. The PDM has passed through three generations, with each successive generation addressing issues that have arisen from experiment or theory. Thus, the first generation model (PDM-I), developed in the early 1980s, assumed that the passive film was a single defective oxide layer that contained cation vacancies and oxygen vacancies that were generated and annihilated at the metal/film and film/solution interfaces, as inspired by the work by Wagner on high temperature oxidation. As with gas-phase systems, the film was assumed not to dissolve. However, it soon became evident that this model could not account for the properties of the passive state on metals in contact with aqueous environments and, accordingly a Generation II model (PDM-II) was developed to address these issues. PDM-II incorporated the bi-layer structure of the film comprising a defective oxide or hydride barrier layer adjacent to the metal and an outer layer that forms by precipitation of material from reaction of transmitted cations with species in the environment (including water, CO
3
2−, HS
−, etc.), introduced metal interstitials to the suite of defects, recognized barrier layer dissolution, and recognized the need to classify reactions as to whether they are lattice conservative or non-conservative, but assumed that control of the passive current resided in the barrier layer alone. PDM-II has enjoyed considerable success and the author knows of no instance where it has been demonstrated to be at odds with experiment when confluence between experiment and theory has been demonstrated. A Generation III model (PDM-III) has been recently developed to extend the theory to those cases (e.g., the valve metals) where the outer layer is so resistive that it controls the impedance of the interface and hence the corrosion rate. A fourth generation model that will describe passivity on alloys is now under development. The experimental evidence upon which each generation is based is reviewed.
Organic farming practices have been promoted as, inter alia, reducing the environmental impacts of agriculture. This meta-analysis systematically analyses published studies that compare environmental ...impacts of organic and conventional farming in Europe. The results show that organic farming practices generally have positive impacts on the environment per unit of area, but not necessarily per product unit. Organic farms tend to have higher soil organic matter content and lower nutrient losses (nitrogen leaching, nitrous oxide emissions and ammonia emissions) per unit of field area. However, ammonia emissions, nitrogen leaching and nitrous oxide emissions per product unit were higher from organic systems. Organic systems had lower energy requirements, but higher land use, eutrophication potential and acidification potential per product unit. The variation within the results across different studies was wide due to differences in the systems compared and research methods used. The only impacts that were found to differ significantly between the systems were soil organic matter content, nitrogen leaching, nitrous oxide emissions per unit of field area, energy use and land use. Most of the studies that compared biodiversity in organic and conventional farming demonstrated lower environmental impacts from organic farming. The key challenges in conventional farming are to improve soil quality (by versatile crop rotations and additions of organic material), recycle nutrients and enhance and protect biodiversity. In organic farming, the main challenges are to improve the nutrient management and increase yields. In order to reduce the environmental impacts of farming in Europe, research efforts and policies should be targeted to developing farming systems that produce high yields with low negative environmental impacts drawing on techniques from both organic and conventional systems.
► On a per area basis organic farming, generally, has low environmental impacts. ► The benefits of organic farming are reduced when using product unit comparison. ► High levels of variation exist within both organic and conventional systems. ► Modelling studies tend to overestimate the benefits of organic farming. ► The relative impacts of the systems vary between different product groups.
In order to compliment the current interest in lesions affecting the face and jaws in Clinical Radiology , this overview addresses recent developments in the classification, nomenclature, clinical ...and radiological diagnosis, and outcomes of treatment of the most important and frequent lesions that present as radiolucencies on conventional radiography of the jaws. Although termed “benign” a significant proportion of each odontogenic neoplasm can recur after conservative surgery. Two diagnostic flowcharts take the clinician from the radiological presentation of a lesion in the jaw to an appropriate diagnosis. The recent advent of cone-beam computed tomography (CBCT) can enhance the quality of the diagnosis and preoperative assessment of such lesions. CBCT images of typical benign neoplasms, cysts, and other phenomena affecting the face and jaws are included. The relative period prevalences of the lesions, based on the most recent UK reports, are included. The importance to the radiologist of an emerging lesion of the jaws, the glandular odontogenic cyst, is discussed.
The history of electrochemical impedance spectroscopy (EIS) is briefly reviewed, starting with the foundations laid by Heaviside in the late 19th century in the form of Linear Systems Theory (LST). ...Warburg apparently was the first to extend the concept of impedance to electrochemical systems at the turn of the 19th century, when he derived the impedance function for a diffusional process that still bears his name. Impedance spectroscopy was next employed extensively using reactive bridges to measure the capacitance of ideally polarizable electrodes (mostly mercury), leading to the development of models for the electrified interface. However, it was the invention of the potentiostat in the 1940s and the development of frequency response analyzers in the 1970s that led to the use of EIS in exploring electrochemical and corrosion mechanisms, primarily because of their ability to probe electrochemical systems at very low frequencies. These inventions have led to an explosion in the use of EIS for exploring a wide range of systems and processes, ranging from conduction in the solid and liquid states, ionic and electronic conduction in polymers, heterogeneous reaction mechanisms, and the important phenomenon of passivity. It is evident that the use of EIS in identifying reaction mechanisms makes use of pattern recognition, currently through inspection. It is argued that, in the future development of EIS, reaction mechanism analysis (RMA) would be most efficiently done by using artificial neural networks operating in the pattern recognition mode. This strategy would require the creation of libraries of reaction mechanisms for which the theoretical impedance functions are known.
Summary Although low-grade gliomas (LGG) have a less aggressive course than do high-grade gliomas, the outcome of these tumours is ultimately fatal in most patients. Both the tumour and its treatment ...can cause disabling morbidity, particularly of cognitive functions. Because many patients present with seizures only, with no other signs and symptoms, maintenance of quality of life and function constitutes a particular challenge in LGG. The slow growth pattern of most LGG, and the rare radiological true responses despite a favourable clinical response to treatment, interferes with the use of progression-free survival as the primary endpoint in trials. Overall survival as an endpoint brings logistical challenges, and is sensitive to other non-investigational salvage therapies. Clinical trials for LGG need to consider other measures of patient benefit such as cognition, symptom burden, and seizure activity, to establish whether improved survival is reflected in prolonged wellbeing. This Review investigates clinical and imaging endpoints in trials of LGG, and provides response assessment in neuro-oncology (RANO) criteria for non-enhancing tumours. Additionally, other measures for patients with brain tumours that assess outcome are described. Similar considerations are relevant for trials of high-grade gliomas, although for these tumours survival is shorter and survival endpoints generally have more value than they do for LGG.
As COVID-19 vaccine distribution efforts continue, public health workers can strategize about vaccine promotion in an effort to increase willingness among those who may be hesitant.
In April 2020, we ...surveyed a national probability sample of 2279 U.S. adults using an online panel recruited through address-based sampling. Households received a computer and internet access if needed to participate in the panel. Participants were invited via e-mail and answered online survey questions about their willingness to get a novel coronavirus vaccine when one became available. The survey was completed in English and Spanish. We report weighted percentages.
Most respondents were willing to get the vaccine for themselves (75%) or their children (73%). Notably, Black respondents were less willing than White respondents (47% vs. 79%, p < 0.001), while Hispanic respondents were more willing than White respondents (80% vs. 75%, p < 0.003). Females were less likely than makes (72% vs. 79%, p < 0.001). Those without insurance were less willing than the insured (47% vs. 78%, p < 0.001). Willingness to vaccinate was higher for those age 65 and older than for some younger age groups (85% for those 65 and older vs. 75% for those 50-64, p < 0.017; 72% for those 35-49, p < 0.002; 70% for those 25-34, p = NS and 75% for ages 18-24, p = NS), but other groups at increased risk because of underlying medical conditions or morbid obesity were not more willing to get vaccinated than their lower risk counterparts.
Most Americans were willing to get a COVID-19 vaccine, but several vulnerable populations reported low willingness. Public health efforts should address these gaps as national implementation efforts continue.
The promise of gene therapy for the treatment of cystic fibrosis has yet to be fully clinically realized despite years of effort toward correcting the underlying genetic defect in the cystic fibrosis ...transmembrane conductance regulator (CFTR). mRNA therapy via nanoparticle delivery represents a powerful technology for the transfer of genetic material to cells with large, widespread populations, such as airway epithelia. We deployed a clinically relevant lipid-based nanoparticle (LNP) for packaging and delivery of large chemically modified CFTR mRNA (cmCFTR) to patient-derived bronchial epithelial cells, resulting in an increase in membrane-localized CFTR and rescue of its primary function as a chloride channel. Furthermore, nasal application of LNP-cmCFTR restored CFTR-mediated chloride secretion to conductive airway epithelia in CFTR knockout mice for at least 14 days. On day 3 post-transfection, CFTR activity peaked, recovering up to 55% of the net chloride efflux characteristic of healthy mice. This magnitude of response is superior to liposomal CFTR DNA delivery and is comparable with outcomes observed in the currently approved drug ivacaftor. LNP-cmRNA-based systems represent a powerful platform technology for correction of cystic fibrosis and other monogenic disorders.
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The use of lipid nanoparticles to deliver therapeutic mRNA is an increasingly attractive gene therapy modality. Here, Robinson et al. demonstrate that lipid nanoparticle transfection of mRNA can repair the central defect in cystic fibrosis, chloride transport, both in vitro and in vivo. The authors discuss why this technology is a promising treatment option for monogenic disorders such as cystic fibrosis.
Purpose
To propose guidelines based on an expert-panel-derived unified approach to the technical performance, interpretation, and reporting of MRI for baseline and post-treatment staging of rectal ...carcinoma.
Methods
A consensus-based questionnaire adopted with permission and modified from the European Society of Gastrointestinal and Abdominal Radiologists was sent to a 17-member expert panel from the Rectal Cancer Disease-Focused Panel of the Society of Abdominal Radiology containing 268 question parts. Consensus on an answer was defined as ≥ 70% agreement. Answers not reaching consensus (< 70%) were noted.
Results
Consensus was reached for 87% of items from which recommendations regarding patient preparation, technical performance, pulse sequence acquisition, and criteria for MRI assessment at initial staging and restaging exams and for MRI reporting were constructed.
Conclusion
These expert consensus recommendations can be used as guidelines for primary and post-treatment staging of rectal cancer using MRI.
Highlights • This article comprehensively reviews intraoperative motor evoked potentials. • It then forms summary recommendations based on current evidence and expert opinion. • The International ...Society of Intraoperative Neurophysiology collaborated and endorses this position statement.
Predators may influence their prey populations not only through direct lethal effects, but also through indirect behavioral changes. Here, we combined spatiotemporal fine-scale data from GPS radio ...collars on lions with habitat use information on 11 African herbivores in Hwange National Park (Zimbabwe) to test whether the risk of predation by lions influenced the distribution of herbivores in the landscape. Effects of long-term risk of predation (likelihood of lion presence calculated over four months) and short-term risk of predation (actual presence of lions in the vicinity in the preceding 24 hours) were contrasted. The long-term risk of predation by lions appeared to influence the distributions of all browsers across the landscape, but not of grazers. This result strongly suggests that browsers and grazers, which face different ecological constraints, are influenced at different spatial and temporal scales in the variation of the risk of predation by lions. The results also show that all herbivores tend to use more open habitats preferentially when lions are in their vicinity, probably an effective anti-predator behavior against such an ambush predator. Behaviorally induced effects of lions may therefore contribute significantly to structuring African herbivore communities, and hence possibly their effects on savanna ecosystems.