The research aim is to prove by experiments the use of biologically active compounds in feeding of gosling broilers and geese of a parent flock for decrease of meat and incubation egg production ...prime cost and for increase of their quality. The effec of DL-methionin enzyme preparations Avizim 1100, Avizim 1200 and Natufos 10 000 and Se-containing preparation (Na selenites and Sel-Plex has been investigated. he enzyme preparation Natufos 10 000 at a dosage of 0.0055 per weight is recommended for meat production and they are to be fed by wheat or wheat and barley mixed feeds enriched by Avizim 1200 and Naturofos 10 000 (Avizim 1100 is added into barley feed). It is reasonable to add DL-methionine (0.75% on the beginning of growing and 0.57% from the 5 week) into mixed feed for increase meat productivity and meat quality
Intracellular Local Ca releases (LCRs) from sarcoplasmic reticulum (SR) regulate cardiac pacemaker cell function by activation of electrogenic Na/Ca exchanger (NCX) during diastole. Prior studies ...demonstrated the existence of powerful compensatory mechanisms of LCR regulation via a complex local cross-talk of Ca pump, release and NCX. One major obstacle to study these mechanisms is that LCR exhibit complex Ca release propagation patterns (including merges and separations) that have not been characterized. Here we developed new terminology, classification, and computer algorithms for automatic detection of numerically simulated LCRs and examined LCR regulation by SR Ca pumping rate (Pup) that provides a major contribution to fight-or-flight response. In our simulations the faster SR Ca pumping accelerates action potential-induced Ca transient decay and quickly clears Ca under the cell membrane in diastole, preventing premature releases. Then the SR generates an earlier, more synchronized, and stronger diastolic LCR signal activating an earlier and larger inward NCX current. LCRs at higher Pup exhibit larger amplitudes and faster propagation with more collisions to each other. The LCRs overlap with Ca transient decay, causing an elevation of the average diastolic Ca nadir to ~200 nM (at Pup = 24 mM/s). Background Ca (in locations lacking LCRs) quickly decays to resting Ca levels (<100 nM) at high Pup, but remained elevated during slower decay at low Pup. Release propagation is facilitated at higher Pup by a larger LCR amplitude, whereas at low Pup by higher background Ca. While at low Pup LCRs show smaller amplitudes, their larger durations and sizes combined with longer transient decay stabilize integrals of diastolic Ca and NCX current signals. Thus, the local interplay of SR Ca pump and release channels regulates LCRs and Ca transient decay to insure fail-safe pacemaker cell operation within a wide range of rates.
The authors offer a comprehensive gnoseological and axiological study of the prerequisites that may become the grounds for Ukraine’s integration into the EU: social, economic, cultural-historical, ...and other prerequisites. This practical reflection aims to identify the extent to which Ukraine is currently integrated into the EU. From the geopolitical viewpoint, the act of Ukraine’s accession to the European Union is a formality, which implies the agreement of the EU members to accept Ukraine as an equal actor in a shared, unified economic, cultural, and historical space. Certainly, a decision of this kind should be dictated by concrete, historically substantiated grounds, that is, reasons proven by time and the logic of history.
Cardiac pacemaking is a complex phenomenon that is still not completely understood. Together with experimental studies, numerical modeling has been traditionally used to acquire mechanistic insights ...in this research area. This review summarizes the present state of numerical modeling of the cardiac pacemaker, including approaches to resolve present paradoxes and controversies. Specifically we discuss the requirement for realistic modeling to consider symmetrical importance of both intracellular and cell membrane processes (within a recent “coupled-clock” theory). Promising future developments of the complex pacemaker system models include the introduction of local calcium control, mitochondria function, and biochemical regulation of protein phosphorylation and cAMP production. Modern numerical and theoretical methods such as multi-parameter sensitivity analyses within extended populations of models and bifurcation analyses are also important for the definition of the most realistic parameters that describe a robust, yet simultaneously flexible operation of the coupled-clock pacemaker cell system. The systems approach to exploring cardiac pacemaker function will guide development of new therapies such as biological pacemakers for treating insufficient cardiac pacemaker function that becomes especially prevalent with advancing age.
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