A phase modulated RF current source is applied to an injection locked diode laser operating at \(780\unit{nm}\). This produces tunable phase modulated sidebands of the laser suitable for stabilizing ...the length of an optical transfer cavity using the Pound-Drever-Hall technique. The Pound-Drever-Hall signal is anti-symmetric about the lock point, despite the presence of significant diode laser amplitude modulation. The stabilized optical transfer cavity is used to frequency stabilize a 776 nm external cavity diode laser. The stability and tunability of this transfer cavity locked laser is established by observation of the hyperfine components of the \(^{87}\)Rb \(5P_{3/2}-5D_{5/2}\) transition in a vapor cell.
Cardiac excitation originates in the sinoatrial node (SAN), due to the automaticity of this distinct region of the heart. SAN automaticity is the result of a gradual depolarisation of the membrane ...potential in diastole, driven by a coupled system of transarcolemmal ion currents and intracellular Ca
cycling. The frequency of SAN excitation determines heart rate and is under the control of extra- and intracardiac (extrinsic and intrinsic) factors, including neural inputs and responses to tissue stretch. While the structure, function, and control of the SAN have been extensively studied in mammals, and some critical aspects have been shown to be similar in zebrafish, the specific drivers of zebrafish SAN automaticity and the response of its excitation to vagal nerve stimulation and mechanical preload remain incompletely understood. As the zebrafish represents an important alternative experimental model for the study of cardiac (patho-) physiology, we sought to determine its drivers of SAN automaticity and the response to nerve stimulation and baseline stretch. Using a pharmacological approach mirroring classic mammalian experiments, along with electrical stimulation of intact cardiac vagal nerves and the application of mechanical preload to the SAN, we demonstrate that the principal components of the coupled membrane- Ca
pacemaker system that drives automaticity in mammals are also active in the zebrafish, and that the effects of extra- and intracardiac control of heart rate seen in mammals are also present. Overall, these results, combined with previously published work, support the utility of the zebrafish as a novel experimental model for studies of SAN (patho-) physiological function.
The Silicon photomultiplier-based Compton Telescope for Safety and Security (SCoTSS) has been developed incorporating end-user requirements into the design process. The end-user group includes those ...responsible for mobile survey in the event of a radiological or nuclear accident, those responsible for radiation survey support to security operations at major events and at Canadian borders, as well as some of those responsible for Canadian defense applications. The SCoTSS development program has reached a technology readiness level of eight, and we are proceeding with field trials of the instrument in high-fidelity operational environments. Prospective end users have been involved in trial set up and execution, assuring applicability in their mission spaces. SCoTSS has been subject to trials involving hidden sources, heavily shielded sources, imager moving with respect to source, and complicated man-made surroundings. Our operators value high sensitivity for anomaly geolocation and mapping. End users also require an instrument which is capable of direction reconstruction in motion, as well as rapid imaging of a field of view. We have developed a “time to image” measure which allows for quantitative comparison of imagers of fundamentally different technology, where one design may have an advantage in terms of energy resolution and compactness and another design may have an advantage in terms of efficiency and cost effectiveness. We present here the performance of the SCoTSS imager in rapid direction finding. As well, we compare the time to image quantity for the SCoTSS imager and the H3D Polaris-H Quad imager where the data were taken under equivalent conditions. This quantitative measure of imaging performance can allow operators to make an informed choice of the design that meets their needs taking into consideration also weight and size as well as budgetary constraints.
The SiPM-based Compton Telescope for Safety and Security (SCoTSS) has been developed with inorganic crystalline scintillator material for gamma detection. The instrument is sensitive enough to be ...used in a mobile survey mode, accumulating energy deposited in any crystal second-by-second and tagging these spectra with GPS position. The SCoTSS imager of course has the additional advantage of being able to produce an image of the radioactive objects in its field of view using events that satisfy a coincidence trigger between the scatter and absorber layers. The Advanced Radiation Detector for UAV Operations (ARDUO) on the other hand, is a non-imaging directional detector intended for use aboard a small unmanned aerial vehicle (UAV). The ARDUO detector features exactly the same volume of CsI(Tl) as is used in the absorber layer of a single SCoTSS module, giving it similar detection and alarming sensitivity, and mapmaking capability. However, in the ARDUO detector, the crystals are arranged closely together to optimize direction determination from self-shielding effects. Flown in a grid pattern with a UAV over an area of extended contamination, the ARDUO detector is also capable of making a map or image of that area. With its close-packed crystal arrangement, the ARDUO detector makes a poor Compton imager but does have some ability to produce a peripheral image in a fly-by. In this presentation we investigate the relative merits of Compton imaging versus mobile directional detection.
The Silicon photomultiplier-based Compton Telescope for Safety and Security (SCoTSS) has been developed incorporating end-user requirements into the design process. The end-user group includes those ...responsible for mobile survey in the event of a radiological or nuclear accident, those responsible for radiation survey support to security operations at major events and at Canadian borders, as well as some of those responsible for Canadian defense applications. The SCoTSS development program has reached a technology readiness level of eight, and we are proceeding with field trials of the instrument in high-fidelity operational environments. Prospective end users have been involved in trial set up and execution, assuring applicability in their mission spaces. SCoTSS has been subject to trials involving hidden sources, heavily shielded sources, imager moving with respect to source, and complicated man-made surroundings. Our operators value high sensitivity for anomaly geolocation and mapping. End users also require an instrument which is capable of direction reconstruction in motion, as well as rapid imaging of a field of view. We have developed a "time to image" measure which allows for quantitative comparison of imagers of fundamentally different technology, where one design may have an advantage in terms of energy resolution and compactness and another design may have an advantage in terms of efficiency and cost effectiveness. We present here the performance of the SCoTSS imager in rapid direction finding. As well, we compare the time to image quantity for the SCoTSS imager and the H3D Polaris-H Quad imager where the data were taken under equivalent conditions. This quantitative measure of imaging performance can allow operators to make an informed choice of the design that meets their needs taking into consideration also weight and size as well as budgetary constraints.
Compton gamma imagers are instruments which use the physics of Compton scattering to locate gamma emitters. This makes Compton gamma imagers useful tools for determining the distribution of ...radionuclides within an area which has restricted access. Our group has developed a Compton gamma imager which we call the silicon photomultiplier-based Compton telescope for safety and security (SCoTSS). Using a SCoTSS instrument, we made measurements of an extended source of La-140 that lay within an inaccessible area and implemented a tomographic back-projection algorithm to reconstruct the distribution. We demonstrate our method on simulated data of a point source of La-140 and two extended sources of La-140 for initial validation, and then apply our method to experimental measurements. Our method demonstrates good ability to localize the distribution of La-140 in all cases. Future improvements to our method will include the implementation of iterative methods and quantitative methods to estimate the reconstructed activity.
The SiPM-based Compton Telescope for Safety and Security (SCoTSS) has been developed with inorganic crystalline scintillator material for gamma detection. The instrument is sensitive enough to be ...used in a mobile survey mode, accumulating energy deposited in any crystal second-by-second and tagging these spectra with GPS position. The SCoTSS imager of course has the additional advantage of being able to produce an image of the radioactive objects in its field of view using events that satisfy a coincidence trigger between the scatter and absorber layers. The Advanced Radiation Detector for UAV Operations (ARDUO) on the other hand, is a non-imaging directional detector intended for use aboard a small unmanned aerial vehicle (UAV). The ARDUO detector features exactly the same volume of CsI(Tl) as is used in the absorber layer of a single SCoTSS module, giving it similar detection and alarming sensitivity, and map-making capability. However, in the ARDUO detector, the crystals are arranged closely together to optimize direction determination from self-shielding effects. Flown in a grid pattern with a UAV over an area of extended contamination, the ARDUO detector is also capable of making a map or image of that area. With its close-packed crystal arrangement, the ARDUO detector makes a poor Compton imager but does have some ability to produce a peripheral image in a fly-by. In this presentation we investigate the relative merits of Compton imaging versus mobile directional detection.
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