The ctenophore Mnemiopsis leidyi is one of the most successful marine bioinvaders on record. Native to the Atlantic coast of the Americas, M. leidyi invaded the Black Sea, Caspian and Mediterranean ...Seas beginning the in late 1980s, followed by the North and Baltic Seas starting in 2006, with major concomitant alterations in pelagic ecology, including fishery collapses in some cases. Using extensive native range sampling (21 sites), along with 11 invasive sites in the Black, Caspian, Mediterranean, North and Baltic Seas, we examined M. leidyi worldwide phylogeographic patterns using data from mitochondrial cytochrome b (cytb) and six nuclear microsatellite loci. Cytb and microsatellite data sets showed different levels of genetic differentiation in the native range. Analyses of cytb data revealed considerable genetic differentiation, recovering three major clusters (northwestern Atlantic, Caribbean, and South America) and further divided northwestern Atlantic sampling sites into three groups, separated approximately at Cape Hatteras on the US Atlantic coast and at the Floridian peninsula, separating the Gulf of Mexico and Atlantic coasts. In contrast, microsatellite data only distinguished samples north and south of Cape Hatteras, and suggested considerable gene flow among native samples with clear evidence of isolation by distance. Both cytb and microsatellite data sets indicated that the northern invaders (North/Baltic Seas) originated from north of Cape Hatteras, with cytb data pointing to Delaware and north. Microsatellite data indicated a source for the southern invaders (Black, Caspian and Mediterranean Seas) to be south of Cape Hatteras, while cytb data narrowed the source location to the Gulf of Mexico region. Both cytb and microsatellite data sets suggested that the southern invasion was associated with genetic bottlenecks while evidence was equivocal for the northern invasion. By increasing the native range spatial sampling, our dataset was able to sufficiently characterize patterns and levels of genetic differentiation in the native range of M. leidyi and identify likely biogeographic boundaries, allowing for the most complete characterization of M. leidyi’s invasion histories and most realistic estimates of its source region(s) to date.
Background: The clinical condition of advanced Parkinson’s disease (PD) patients is often complicated by motor fluctuations and dyskinesias which are difficult to control with available oral ...medications. Objective: To compare clinical and neuropsychological 12 month outcome following subcutaneous apomorphine infusion (APO) and chronic deep brain stimulation of the subthalamic nucleus (STN-DBS) in advanced PD patients. Methods: Patients with advanced PD and medically untreatable fluctuations underwent either APO (13 patients) or STN-DBS (12 patients). All patients were clinically (UPDRS-III, AIMS, 12 h on-off daily) and neuropsychologically (MMSE, Hamilton-17 depression, NPI) evaluated at baseline and at 12 months. APO was discontinued at night. Results: At 12 months APO treatment (74.78±24.42 mg/day) resulted in significant reduction in off time (−51%) and no change in AIMS. Levodopa equivalent medication doses were reduced from 665.98±215 mg/day at baseline to 470±229 mg/day. MMSE, NPI, and Hamilton depression scores were unchanged. At 12 months STN-DBS resulted in significant clinical improvement in terms of reduction in daily off time (−76%) and AIMS (−81%) as well as levodopa equivalent medication doses (980±835 to 374±284 mg/day). Four out of 12 patients had stopped oral medications. MMSE was unchanged (from 28.6±0.3 to 28.4±0.6). Hamilton depression was also unchanged, but NPI showed significant worsening (from 6.58±9.8 to 18.16±10.2; p<0.02). Category fluency also declined. Conclusions: Both APO and STN-DBS resulted in significant clinical improvement in complicated PD. STN-DBS resulted in greater reduction in dopaminergic medications and provided 24 h motor benefit. However, STN-DBS, unlike APO, appears to be associated with significant worsening on NPI resulting from long term behavioral problems in some patients.
Diffusion tensor imaging (DTI) offers a unique window on the connectivity changes, extending beyond the basal ganglia, which accompany the cognitive symptoms of Parkinson disease (PD). The primary ...purpose of this study was to assess the microstructural damage to cerebral white matter occurring in idiopathic PD.
Our sample included patients with PD without dementia (n = 10; Hoehn and Yahr stages I and II; Unified Parkinson Disease Rating Scale, 20.5 +/- 8.3; and Mini-Mental State Examination, 28.3 +/- 1.5) and age-matched healthy control subjects (n = 10). DTI was performed on a 1.5T scanner, and mean diffusivity (MD) and fractional anisotropy (FA) maps were obtained. Regions of interest (ROIs) were drawn on the major fiber bundles as well as on gray matter nuclei.
In patients, the MD was increased at borderline significance in the substantia nigra but was unaltered in the thalamus, globus pallidus, putamen, and in the head of the caudate nucleus. The FA and MD were unaltered in the corticospinal tract in the midbrain and at the level of the internal capsule, and in the splenium of the corpus callosum. By contrast, the MD was increased and the FA was decreased in the genu of the corpus callosum and in the superior longitudinal fasciculus; in the cingulum, only the MD was altered. The observed changes were not significantly lateralized.
Widespread microstructural damage to frontal and parietal white matter occurs already in the early stages of PD.
We report measurements of cross sections of neutrinos of 0.7 GeV average energy scattering off a carbon target cross sections with by the SciBooNE experiment at Fermilab. These measurements are ...important inputs for current and future accelerator-based neutrino oscillation experiments in the interpretation of neutrino oscillation signals.
BACKGROUND: Acute intervertebral disk herniation (IVDH) is a common cause of spinal cord injury in dogs and currently there is no proven medical treatment to counter secondary injury effects. Use of ...methylprednisolone sodium succinate (MPSS) or polyethylene glycol (PEG) as neuroprotectants is advocated but controversial because neither treatment has been tested in placebo‐controlled, randomized, blinded trials in dogs. HYPOTHESIS: Polyethylene glycol will improve the outcome of severe spinal cord injury caused by IVDH compared to MPSS or placebo. ANIMALS: Client‐owned dogs with acute onset of thoracolumbar IVDH causing paralysis and loss of nociception for <24 hours. METHODS: Dogs were randomized to receive MPSS, PEG, or placebo; drugs appeared identical and group allocation was masked. Drug administration was initiated once the diagnosis of IVDH was confirmed and all dogs underwent hemilaminectomy. Neurologic function was assessed 2, 4, 8, and 12 weeks postoperatively using an open field gait score (OFS) as the primary outcome measure. Outcomes were compared by the Wilcoxon rank sum test. RESULTS: Sixty‐three dogs were recruited and 47.6% recovered ambulation. 17.5% developed progressive myelomalacia but there was no association with group. There was no difference in OFS among groups. Although full study power was not reached, conditional power analyses indicated the futility of continued case recruitment. CONCLUSIONS: This clinical trial did not show a benefit of either MPSS or PEG in the treatment of acute, severe thoracolumbar IVDH when used as adjunctive medical treatment administered to dogs presenting within 24 hours of onset of paralysis.
In this paper, we have modified the Detrended Fluctuation Analysis (DFA) using the ternary Cantor set. We propose a modification of the DFA algorithm, Cantor DFA (CDFA), which uses the Cantor set ...theory of base 3 as a scale for segment sizes in the DFA algorithm. An investigation of the phenomena generated from the proof using real-world time series based on the theory of the Cantor set is also conducted. This new approach helps reduce the overestimation problem of the Hurst exponent of DFA by comparing it with its inverse relationship with α of the Truncated Lévy Flight (TLF). CDFA is also able to correctly predict the memory behavior of time series.
Abstract
We present the ‘dark-PMT’, a novel detector concept based around a target made of vertically-aligned carbon nanotubes. The detector is sensitive to electron recoils induced by sub-GeV dark ...matter, and is expected to have directional sensitivity and to be unaffected by thermal noise, even at room temperature. The key feature is that nanotubes are made of graphene, which is a two-dimensional material: therefore, if a dark matter particle transfers enough energy to an electron in the carbon lattice to overcome the work function (4.7 eV), the electron will be ejected directly into the vacuum. Because of the strong density anisotropy of nanotubes, the electrons will be capable of leaving the target, without being reabsorbed, if travelling in the direction of the tube axes. The electrons will then be accelerated, and reach an energy of 5 keV before hitting an electron sensor. We report on the most recent advancements towards the construction of a dark-PMT: a novel, state-of-the-art facility for nanotube synthesis has been recently installed in Rome, and it is being used to produce high-quality nanotubes; and detailed characterizations of silicon sensors with keV electrons have been performed.
In this article, we introduce the multifractal conditional diffusion entropy method for analyzing the volatility of financial time series. This method utilizes a q-order diffusion entropy based on a ...q-weighted time lag scale. The technique of conditional diffusion entropy proves valuable for examining bull and bear behaviors in stock markets across various time scales. Empirical findings from analyzing the Dow Jones Industrial Average (DJI) indicate that employing multi-time lag scales offers greater insight into the complex dynamics of highly fluctuating time series, often characterized by multifractal behavior. A smaller time scale like t=2 to t=256 coincides more with the state of the DJI index than larger time scales like t=256 to t=1024. We observe extreme fluctuations in the conditional diffusion entropy for DJI for a short time lag, while smoother or averaged fluctuations occur over larger time lags.
The Double Chooz antineutrino detectors Abe, Y.; Alba, J.; Barriere, J. C. ...
The European physical journal. C, Particles and fields,
09/2022, Letnik:
82, Številka:
9
Journal Article
Recenzirano
Odprti dostop
This article describes the setup and performance of the near and far detectors in the Double Chooz experiment. The electron antineutrinos of the Chooz nuclear power plant were measured in two ...identically designed detectors with different average baselines of about 400 m and 1050 m from the two reactor cores. Over many years of data taking the neutrino signals were extracted from interactions in the detectors with the goal of measuring a fundamental parameter in the context of neutrino oscillation, the mixing angle
θ
13
. The central part of the Double Chooz detectors was a main detector comprising four cylindrical volumes filled with organic liquids. From the inside towards the outside there were volumes containing gadolinium-loaded scintillator, gadolinium-free scintillator, a buffer oil and, optically separated, another liquid scintillator acting as veto system. Above this main detector an additional outer veto system using plastic scintillator strips was installed. The technologies developed in Double Chooz were inspiration for several other antineutrino detectors in the field. The detector design allowed implementation of efficient background rejection techniques including use of pulse shape information provided by the data acquisition system. The Double Chooz detectors featured remarkable stability, in particular for the detected photons, as well as high radiopurity of the detector components.
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