U radu se istražuje zastupljenost usmene književnosti u lektirnim književnim djelima predmetne nastave hrvatskih autora, koja su propisana Nastavnim planom i programom za osnovnu školu i koja ...interferiraju s usmenom književnošću. Izdvajale su se interferencije na temelju strukture, teme i motiva, likova, jezične igre, zavičajnosti, usmenoknjiževnih oblika i dr. Dolazi se do spoznaja kako je usmena književnost poprilično zastupljena, a da su se interferencije najviše odvijale na temelju zavičajnosti i domoljubnosti, tema i motiva te usmenoknjiževnih oblika. Istraživanje je dokazalo da su elementi usmene književnosti čvrsto i duboko umetnuti u lektirna književna djela hrvatskih autora i da se ni u kom slučaju ne smiju smatrati perifernim elementima kao što je bilo dugo vremena na hrvatskoj književnoj sceni kada se usmena književnost sustavno zanemarivala.
The paper investigates the representation of oral literature in reading literary works ofsubject teaching by Croatian authors, which are prescribed by the Curriculum for primaryschool and which ...interfere with oral literature. Interferences were singled out on the basisof structure, theme and motives, characters, language game, homeland, oral literary forms,etc. It is realized that oral literature is quite represented, and that interferences mostlytook place on the basis of homeland and patriotism, motives and oral literary forms. Theresearch proved that the elements of oral literature are firmly and deeply inserted in thereading works of Croatian authors and that in no case should they be considered peripheralelements as was the case for a long time on the Croatian literary scene when oral literaturewas systematically neglected.
The aim of this study was to investigate the association of smoking with disease activity, seropositivity, age and gender in patients with rheumatoid arthritis. We included 89 rheumatoid arthritis ...patients. All patients fulfilled the 2010 American College of Rheumatology/European League Against Rheumatism rheumatoid arthritis classification criteria. Activity of the disease was measured by Disease Activity Score 28-joint count C-reactive protein (DAS28CRP). The subjects were stratified into smoking and non-smoking groups and cross-sectionally analyzed. There were 24 (27%) smokers and 65 (73%) nonsmokers. The mean age of patients was 57.1±8.8 years. The mean DAS28CRP was 5.81 in the smoking group and 5.57 in the non-smoking group, without statistically significant difference between the two groups (p=0.148). Similarly, smokers did not differ significantly from non-smokers according to age (p=0.443), gender (p=0.274), rheumatoid factor positivity (p=0.231), anti-citrullinated protein antibody positivity (p=0.754) or seropositivity (p=0.163). In this study, we found no association between smoking status and disease activity, seropositivity, age or gender in rheumatoid arthritis patients. Furthermore, disease activity was not related to age, gender or seropositivity. Additional studies on the effects of smoking on rheumatoid arthritis activity are needed.
Background:
We analysed clinical and biochemical parameters in predicting severe gastrointestinal (GI) manifestations in childhood IgA vasculitis (IgAV) and the risk of developing renal ...complications.
Methods:
A national multicentric retrospective study included children with IgAV reviewed in five Croatian University Centres for paediatric rheumatology in the period 2009–2019.
Results:
Out of 611 children, 281 (45.99%) had at least one GI manifestation, while 42 of 281 (14.95%) had the most severe GI manifestations. Using logistic regression several clinical risk factors for the severe GI manifestations were identified: generalized rash odds ratio (OR) 2.09 (95% confidence interval (CI) 1.09–4.01), rash extended on upper extremities (OR 2.77 (95% CI 1.43–5.34) or face OR 3.69 (95% CI 1.42–9.43) and nephritis (IgAVN) OR 4.35 (95% CI 2.23–8.50), as well as lower values of prothrombin time (OR 0.05 (95% CI 0.01–0.62), fibrinogen OR 0.45 (95% CI 0.29–0.70) and IgM OR 0.10 (95% I 0.03–0.35) among the laboratory parameters. Patients with severe GI involvement more frequently had relapse of the disease OR 2.14 (CI 1.04–4.39) and recurrent rash OR 2.61 (CI 1.27–5.38). Multivariate logistic regression found that the combination of age, GI symptoms at the beginning of IgAV and severity of GI symptoms were statistically significant predictors of IgAVN. Patients in whom IgAV has started with GI symptoms OR 6.60 (95% CI 1.67–26.06), older children OR 1.22 (95% CI 1.02–1.46) with severe GI form of IgAV (OR 5.90 (95% CI 1.12–31.15) were particularly high-risk for developing IgAVN.
Conclusion:
We detected a group of older children with the onset of GI symptoms before other IgAV symptoms and severe GI form of the IgAV, with significantly higher risk for acute and chronic complications of IgAV.
Introduction
Several histologic classifications are used in the evaluation of IgA vasculitis nephritis (IgAVN), however, to date, no studies have determined which one has the strongest association ...with the severity of IgAVN and, as a consequence, its outcomes.
Materials and methods
Patients included in the study were diagnosed with IgAV and IgAVN in seven tertiary university medical centers in Croatia, Italy and Israel. The International Study of Kidney Disease in Children (ISKDC), Haas, Oxford, and Semiquantitative classification (SQC) classifications were used in the analysis and description of renal biopsy. Time from biopsy to outcome evaluation was a statistically significant factor in outcome prediction that was used to define the base model, and was a covariate in all the tested models.
Results
Sixty-seven patients were included in this study. The SQC classification proved to be the best one in outcome prediction, followed by the Oxford classification. The ISKDC and Haas classifications could not predict renal outcome. The Oxford parameters for mesangial hypercellularity and tubular atrophy, as well as the SQC parameters for cellular crescents showed an independent statistically significant contribution to outcome prediction. High level of twenty-four hour protein excretion was associated with a higher grade in the Oxford, SQC and ISKDC classifications. Endocapillary proliferation was positively associated with the Pediatric Vasculitis Activity Score (PVAS) at diagnosis, while tubular atrophy was negatively associated.
Conclusion
The SQC, followed by the Oxford classification were found to provide the best classifications of renal biopsy analysis in patients to predict the outcome in patients with IgAVN. Cellular crescents, mesangial hypercellularity and tubular atrophy showed significant contributions, indicating that active and chronic variables should be included in the estimation.
The aim of this study was to investigate the association of smoking with disease activity, seropositivity, age and gender in patients with rheumatoid arthritis. We included 89 rheumatoid arthritis ...patients. All patients fulfilled the 2010 American College of Rheumatology/European League Against Rheumatism rheumatoid arthritis classification criteria. Activity of the disease was measured by Disease Activity Score 28-joint count C-reactive protein (DAS28CRP). The subjects were stratified into smoking and non-smoking groups and cross-sectionally analyzed. There were 24 (27%) smokers and 65 (73%) nonsmokers. The mean age of patients was 57.1+ or -8.8 years. The mean DAS28CRP was 5.81 in the smoking group and 5.57 in the non-smoking group, without statistically significant difference between the two groups (p=0.148). Similarly, smokers did not differ significantly from non-smokers according to age (p=0.443), gender (p=0.274), rheumatoid factor positivity (p=0.231), anti-citrullinated protein antibody positivity (p=0.754) or seropositivity (p=0.163). In this study, we found no association between smoking status and disease activity, seropositivity, age or gender in rheumatoid arthritis patients. Furthermore, disease activity was not related to age, gender or seropositivity. Additional studies on the effects of smoking on rheumatoid arthritis activity are needed. Key words: Smoking; Rheumatoid arthritis; Rheumatoid factor Cilj ovoga istraivanja bio je ispitati povezanost puenja s aktivnocu bolesti, pozitivnim biokemijskim biljezima, dobi i spolom kod bolesnika s reumatoidnim artritisom. U istraivanju je sudjelovalo 89 ispitanika koji su bolovali od reumatoidnog artritisa. Svi ispitanici su ispunjavali klasifikacijske kriterije za postavljanje dijagnoze reumatoidnog artritisa Americkog reumatolokog drutva i Europske reumatoloke udruge (engl. European League Against Rheumatism, EULAR). Aktivnost bolesti mjerena je prema indeksu aktivnosti bolesti (engl. Disease Activity Score, DAS) koja se procjenjuje na 28 zglobova. Ispitanici su podijeljeni u dvije skupine (puaci i nepuaci) koje su presjecno analizirane. U ispitivanju je sudjelovalo 24 (27%) puaca i 65 (73%) nepuaca. Srednja dob ispitanika bila je 57,1+ or -8,8 godina. Srednje vrijednosti DAS28CRP u skupini puaca iznosile su 5,81, a u skupini nepuaca 5,57, odnosno nije bilo statisticki znacajne razlike izmedu dviju skupina (p=0,148). Takoder, skupina u kojoj su bili puaci nije se znacajno razlikovala u parametrima dobi (p=0,443), spola (p=0,274), pozitivnog reumatoidnog faktora (p=0,231), pozitivnih anti-citrulinskih protutijela (p=0,754) ili seropozitivnosti (p=0,163) od skupine nepuaca. U ovom istraivanju nismo pronali povezanost izmedu puenja i aktivnosti bolesti, seropozitivnosti, dobi i spola kod bolesnika s reumatoidnim artritisom. Nadalje, aktivnost bolesti nije bila povezana s dobi, spolom i seropozitivnocu. Potrebna su daljnja istraivanja utjecaja puenja na aktivnost reumatoidnog artritisa. Kljucne rijeci: Puenje; Reumatoidni artritis; Reumatoidni faktor
Cilj ovoga istraživanja bio je ispitati povezanost pušenja s aktivnošću bolesti, pozitivnim biokemijskim biljezima, dobi i spolom kod bolesnika s reumatoidnim artritisom. U istraživanju je ...sudjelovalo 89 ispitanika koji su bolovali od reumatoidnog artritisa. Svi ispitanici su ispunjavali klasifikacijske kriterije za postavljanje dijagnoze reumatoidnog artritisa Američkog reumatološkog društva i Europske reumatološke udruge (engl. European League Against Rheumatism, EULAR). Aktivnost bolesti mjerena je prema indeksu aktivnosti bolesti (engl. Disease Activity Score, DAS) koja se procjenjuje na 28 zglobova. Ispitanici su podijeljeni u dvije skupine (pušači i nepušači) koje su presječno analizirane. U ispitivanju je sudjelovalo 24 (27%) pušača i 65 (73%) nepušača. Srednja dob ispitanika bila je 57,1±8,8 godina. Srednje vrijednosti DAS28CRP u skupini pušača iznosile su 5,81, a u skupini nepušača 5,57, odnosno nije bilo statistički značajne razlike između dviju skupina (p=0,148). Također, skupina u kojoj su bili pušači nije se značajno razlikovala u parametrima dobi (p=0,443), spola (p=0,274), pozitivnog
reumatoidnog faktora (p=0,231), pozitivnih anti-citrulinskih protutijela (p=0,754) ili seropozitivnosti (p=0,163) od skupine nepušača. U ovom istraživanju nismo pronašli povezanost između pušenja i aktivnosti bolesti, seropozitivnosti, dobi i spola kod bolesnika s reumatoidnim artritisom. Nadalje, aktivnost bolesti nije bila povezana s dobi, spolom i seropozitivnošću. Potrebna su daljnja istraživanja utjecaja pušenja na aktivnost reumatoidnog artritisa.
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