In the effort of the AugerPrime scintillator surface detector R&D activity, we investigated the performances of different extruded and cast plastic scintillators that were read out with ...wavelength-shifting (WLS) optical fibers and then coupled to a PMT. In particular we compared the light yield of eighteen scintillator/fiber configurations, obtained combining eight different scintillator bars with six fiber types, in order to investigate which was satisfying the AugerPrime specifications in terms of light production (>12photoelectrons per minimum ionizing particle). In this paper, we present the results of the study on different scintillator bar geometries, scintillator production techniques, and wavelength-shifting optical fiber types. We also propose an effective way to optically couple the fibers to the PMT entrance window.
In this work, we describe the optical properties of the single photoelectron (SPE) calibration system designed for NectarCAM, a camera proposed for the Medium Sized Telescopes (MST) of the Cherenkov ...Telescope Array (CTA). One of the goals of the SPE system, as integral part of the NectarCAM camera, consists in measuring with high accuracy the gain of its photo-detection chain. The SPE system is based on a white painted screen where light pulses are injected through a fishtail light guide from a dedicated flasher. The screen – placed 15 mm away from the focal plane – is mounted on an XY motorization that allows movements over all the camera plane. This allows in-situ measurements of the SPE spectra via a complete scan of the 1855 photo-multiplier tubes (PMTs) of NectarCAM. This calibration process will enable the reduction of the systematic uncertainties on the energy reconstruction of γ-rays coming from distant astronomical sources and detected by CTA.
We discuss the design of the screen used in the calibration system and we present its optical performances in terms of light homogeneity and timing of the signal.
In this work, we describe the optical properties of the single photoelectron (SPE) calibration system designed for NectarCAM, a camera proposed for the Medium Sized Telescopes (MST) of the Cherenkov ...Telescope Array (CTA). One of the goals of the SPE system, as integral part of the NectarCAM camera, consists in measuring with high accuracy the gain of its photo-detection chain. The SPE system is based on a white painted screen where light pulses are injected through a fishtail light guide from a dedicated flasher. The screen - placed 15 mm away from the focal plane - is mounted on an XY motorization that allows movements over all the camera plane. This allows in-situ measurements of the SPE spectra via a complete scan of the 1855 photo-multiplier tubes (PMTs) of NectarCAM. This calibration process will enable the reduction of the systematic uncertainties on the energy reconstruction of \(\gamma\)-rays coming from distant astronomical sources and detected by CTA.
Reports of honey bee population decline has spurred many national efforts to understand the extent of the problem and to identify causative or associated factors. However, our collective ...understanding of the factors has been hampered by a lack of joined up trans-national effort. Moreover, the impacts of beekeeper knowledge and beekeeping management practices have often been overlooked, despite honey bees being a managed pollinator. Here, we established a standardised active monitoring network for 5 798 apiaries over two consecutive years to quantify honey bee colony mortality across 17 European countries. Our data demonstrate that overwinter losses ranged between 2% and 32%, and that high summer losses were likely to follow high winter losses. Multivariate Poisson regression models revealed that hobbyist beekeepers with small apiaries and little experience in beekeeping had double the winter mortality rate when compared to professional beekeepers. Furthermore, honey bees kept by professional beekeepers never showed signs of disease, unlike apiaries from hobbyist beekeepers that had symptoms of bacterial infection and heavy Varroa infestation. Our data highlight beekeeper background and apicultural practices as major drivers of honey bee colony losses. The benefits of conducting trans-national monitoring schemes and improving beekeeper training are discussed.
Lung cancer is the most common cause of cancer deaths. The expression of the transcription factor C/EBPα (CCAAT/enhancer binding protein α) is frequently lost in non-small cell lung cancer, but the ...mechanisms by which C/EBPα suppresses tumor formation are not fully understood. In addition, no pharmacological therapy is available to specifically target C/EBPα expression. We discovered a subset of pulmonary adenocarcinoma patients in whom negative/low C/EBPα expression and positive expression of the oncogenic protein BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) have prognostic value. We also generated a lung-specific mouse model of C/EBPα deletion that develops lung adenocarcinomas, which are prevented by Bmi1 haploinsufficiency. BMI1 activity is required for both tumor initiation and maintenance in the C/EBPα-null background, and pharmacological inhibition of BMI1 exhibits antitumor effects in both murine and human adenocarcinoma lines. Overall, we show that C/EBPα is a tumor suppressor in lung cancer and that BMI1 is required for the oncogenic process downstream of C/EBPα loss. Therefore, anti-BMI1 pharmacological inhibition may offer a therapeutic benefit for lung cancer patients with low expression of C/EBPα and high BMI1.
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