NUK - logo

Rezultati iskanja

Osnovno iskanje    Ukazno iskanje   

Trenutno NISTE avtorizirani za dostop do e-virov NUK. Za polni dostop se PRIJAVITE.

1 2 3 4 5
zadetkov: 263
1.
  • CryoEM maps are full of pot... CryoEM maps are full of potential
    Marques, Mayra A; Purdy, Michael D; Yeager, Mark Current opinion in structural biology, 10/2019, Letnik: 58
    Journal Article
    Recenzirano
    Odprti dostop

    •Maps derived by X-ray crystallography display electron density, whereas maps derived by electron microscopy display Coulomb potential.•Negatively charged oxygen can result in attenuated positive ...
Celotno besedilo

PDF
2.
  • Phase separation of p53 pre... Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands
    Petronilho, Elaine C; Pedrote, Murilo M; Marques, Mayra A ... Chemical science (Cambridge), 06/2021, Letnik: 12, Številka: 21
    Journal Article
    Recenzirano
    Odprti dostop

    Mutant p53 tends to form aggregates with amyloid properties, especially amyloid oligomers inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF). The mechanism of the ...
Celotno besedilo

PDF
3.
  • New Heteroleptic Ruthenium(... New Heteroleptic Ruthenium(II) Complexes with Sulfamethoxypyridazine and Diimines as Potential Antitumor Agents
    de Melo, Ariane C C; Santana, Jaime M S V P; Nunes, Kelen J R C ... Molecules (Basel, Switzerland), 06/2019, Letnik: 24, Številka: 11
    Journal Article
    Recenzirano
    Odprti dostop

    Two new complexes of Ru(II) with mixed ligands were prepared: Ru(bpy) smp(PF ) ( ) and Ru(phen) smp(PF ) ( ), in which smp = sulfamethoxypyridazine; bpy = 2,2'-bipyridine; phen = 1,10-phenanthroline. ...
Celotno besedilo

PDF
4.
  • Targeting Biomolecular Cond... Targeting Biomolecular Condensation and Protein Aggregation against Cancer
    Silva, Jerson L.; Foguel, Debora; Ferreira, Vitor F. ... Chemical reviews, 07/2023, Letnik: 123, Številka: 14
    Journal Article
    Recenzirano

    Biomolecular condensates, membrane-less entities arising from liquid–liquid phase separation, hold dichotomous roles in health and disease. Alongside their physiological functions, these condensates ...
Celotno besedilo
5.
  • Aggregation-primed molten g... Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer
    Pedrote, Murilo M.; de Oliveira, Guilherme A.P.; Felix, Adriani L. ... The Journal of biological chemistry, 07/2018, Letnik: 293, Številka: 29
    Journal Article
    Recenzirano
    Odprti dostop

    The functionality of the tumor suppressor p53 is altered in more than 50% of human cancers, and many individuals with cancer exhibit amyloid-like buildups of aggregated p53. An understanding of what ...
Celotno besedilo

PDF
6.
  • The intrinsically disordere... The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation
    Johnston, Jamie R.; Landim-Vieira, Maicon; Marques, Mayra A. ... The Journal of biological chemistry, 12/2019, Letnik: 294, Številka: 52
    Journal Article
    Recenzirano
    Odprti dostop

    Aberrant regulation of myocardial force production represents an early biomechanical defect associated with sarcomeric cardiomyopathies, but the molecular mechanisms remain poorly defined. Here, we ...
Celotno besedilo

PDF
7.
  • Water Leakage Pathway Leads... Water Leakage Pathway Leads to Internal Hydration of the p53 Core Domain
    Lima, Igor D. M.; Pedrote, Murilo M.; Marques, Mayra A. ... Biochemistry (Easton), 01/2023, Letnik: 62, Številka: 1
    Journal Article
    Recenzirano

    The gene encoding the p53 tumor suppressor protein is the most frequently mutated oncogene in cancer patients; yet, generalized strategies for rescuing the function of different p53 mutants remain ...
Celotno besedilo
8.
  • The Status of p53 Oligomeri... The Status of p53 Oligomeric and Aggregation States in Cancer
    de Oliveira, Guilherme A P; Petronilho, Elaine C; Pedrote, Murilo M ... Biomolecules (Basel, Switzerland), 04/2020, Letnik: 10, Številka: 4
    Journal Article
    Recenzirano
    Odprti dostop

    Despite being referred to as the guardian of the genome, when impacted by mutations, p53 can lose its protective functions and become a renegade. The malignant transformation of p53 occurs on ...
Celotno besedilo

PDF
9.
  • Protein of a thousand faces... Protein of a thousand faces: The tumor-suppressive and oncogenic responses of p53
    Marques, Mayra A.; Andrade, Guilherme C. de; Silva, Jerson L. ... Frontiers in molecular biosciences, 08/2022, Letnik: 9
    Journal Article
    Recenzirano
    Odprti dostop

    The p53 protein is a pleiotropic regulator working as a tumor suppressor and as an oncogene. Depending on the cellular insult and the mutational status, p53 may trigger opposing activities such as ...
Celotno besedilo
10.
  • The missing links within tr... The missing links within troponin
    Marques, Mayra A.; Parvatiyar, Michelle S.; Yang, Wei ... Archives of biochemistry and biophysics, 03/2019, Letnik: 663
    Journal Article
    Recenzirano
    Odprti dostop

    The cardiac contraction-relaxation cycle is controlled by a sophisticated set of machinery. Of particular interest, is the revelation that allosteric networks transmit effects of binding at one site ...
Celotno besedilo

PDF
1 2 3 4 5
zadetkov: 263

Nalaganje filtrov