Abstract Background Providing supported self-management for people with asthma can reduce the burden on patients, health services and wider society. Implementation, however, remains poor in routine ...clinical practice. IMPlementing IMProved Asthma self-management as RouTine (IMP 2 ART) is a UK-wide cluster randomised implementation trial that aims to test the impact of a whole-systems implementation strategy, embedding supported asthma self-management in primary care compared with usual care. To maximise opportunities for sustainable implementation beyond the trial, it is necessary to understand how and why the IMP 2 ART trial achieved its clinical and implementation outcomes. Methods A mixed-methods process evaluation nested within the IMP 2 ART trial will be undertaken to understand how supported self-management was implemented (or not) by primary care practices, to aid interpretation of trial findings and to inform scaling up and sustainability. Data and analysis strategies have been informed by mid-range and programme-level theory. Quantitative data will be collected across all practices to describe practice context, IMP 2 ART delivery (including fidelity and adaption) and practice response. Case studies undertaken in three to six sites, supplemented by additional interviews with practice staff and stakeholders, will be undertaken to gain an in-depth understanding of the interaction of practice context, delivery, and response. Synthesis, informed by theory, will combine analyses of both qualitative and quantitative data. Finally, implications for the scale up of asthma self-management implementation strategies to other practices in the UK will be explored through workshops with stakeholders. Discussion This mixed-methods, theoretically informed, process evaluation seeks to provide insights into the delivery and response to a whole-systems approach to the implementation of supported self-management in asthma care in primary care. It is underway at a time of significant change in primary care in the UK. The methods have, therefore, been developed to be adaptable to this changing context and to capture the impact of these changes on the delivery and response to research and implementation processes.
ABSTRACT We present a first look at the SCUBA-2 observations of three sub-regions of the Orion B molecular cloud: LDN 1622, NGC 2023/2024, and NGC 2068/2071, from the JCMT Gould Belt Legacy Survey. ...We identify 29, 564, and 322 dense cores in L1622, NGC 2023/2024, and NGC 2068/2071 respectively, using the SCUBA-2 850 m map, and present their basic properties, including their peak fluxes, total fluxes, and sizes, and an estimate of the corresponding 450 m peak fluxes and total fluxes, using the FellWalker source extraction algorithm. Assuming a constant temperature of 20 K, the starless dense cores have a mass function similar to that found in previous dense core analyses, with a Salpeter-like slope at the high-mass end. The majority of cores appear stable to gravitational collapse when considering only thermal pressure; indeed, most of the cores which have masses above the thermal Jeans mass are already associated with at least one protostar. At higher cloud column densities, above 1-2 × 1023 cm−2, most of the mass is found within dense cores, while at lower cloud column densities, below 1 × 1023 cm−2, this fraction drops to 10% or lower. Overall, the fraction of dense cores associated with a protostar is quite small (<8%), but becomes larger for the densest and most centrally concentrated cores. NGC 2023/2024 and NGC 2068/2071 appear to be on the path to forming a significant number of stars in the future, while L1622 has little additional mass in dense cores to form many new stars.
The Southwest Indian Ridge is the longest section of very slow to ultraslow-spreading seafloor in the global mid-ocean ridge system, but the biogeography and ecology of its hydrothermal vent fauna ...are previously unknown. We collected 21 macro- and megafaunal taxa during the first Remotely Operated Vehicle dives to the Longqi vent field at 37° 47'S 49° 39'E, depth 2800 m. Six species are not yet known from other vents, while six other species are known from the Central Indian Ridge, and morphological and molecular analyses show that two further polychaete species are shared with vents beyond the Indian Ocean. Multivariate analysis of vent fauna across three oceans places Longqi in an Indian Ocean province of vent biogeography. Faunal zonation with increasing distance from vents is dominated by the gastropods Chrysomallon squamiferum and Gigantopelta aegis, mussel Bathymodiolus marisindicus, and Neolepas sp. stalked barnacle. Other taxa occur at lower abundance, in some cases contrasting with abundances at other vent fields, and δ
C and δ
N isotope values of species analysed from Longqi are similar to those of shared or related species elsewhere. This study provides baseline ecological observations prior to mineral exploration activities licensed at Longqi by the United Nations.
We present 450 and 850 m submillimeter continuum observations of the IC 5146 star-forming region taken as part of the James Clerk Maxwell Telescope Gould Belt Survey. We investigate the location of ...bright submillimeter (clumped) emission with the larger-scale molecular cloud through comparison with extinction maps, and find that these denser structures correlate with higher cloud column density. Ninety-six individual submillimeter clumps are identified using FellWalker, and their physical properties are examined. These clumps are found to be relatively massive, ranging from 0.5 to 116 with a mean mass of 8 and a median mass of 3.7 . A stability analysis for the clumps suggests that the majority are (thermally) Jeans stable, with . We further compare the locations of known protostars with the observed submillimeter emission, finding that younger protostars, i.e., Class 0 and I sources, are strongly correlated with submillimeter peaks and that the clumps with protostars are among the most Jeans unstable. Finally, we contrast the evolutionary conditions in the two major star-forming regions within IC 5146: the young cluster associated with the Cocoon Nebula and the more distributed star formation associated with the Northern Streamer filaments. The Cocoon Nebula appears to have converted a higher fraction of its mass into dense clumps and protostars, the clumps are more likely to be Jeans unstable, and a larger fraction of these remaining clumps contain embedded protostars. The Northern Streamer, however, has a larger number of clumps in total and a larger fraction of the known protostars are still embedded within these clumps.
ABSTRACT The dust emissivity spectral index, β, is a critical parameter for deriving the mass and temperature of star-forming structures and, consequently, their gravitational stability. The β value ...is dependent on various dust grain properties, such as size, porosity, and surface composition, and is expected to vary as dust grains evolve. Here we present β, dust temperature, and optical depth maps of the star-forming clumps in the Perseus Molecular Cloud determined from fitting spectral energy distributions to combined Herschel and JCMT observations in the 160, 250, 350, 500, and 850 m bands. Most of the derived β and dust temperature values fall within the ranges of 1.0-2.7 and 8-20 K, respectively. In Perseus, we find the β distribution differs significantly from clump to clump, indicative of grain growth. Furthermore, we also see significant localized β variations within individual clumps and find low-β regions correlate with local temperature peaks, hinting at the possible origins of low-β grains. Throughout Perseus, we also see indications of heating from B stars and embedded protostars, as well evidence of outflows shaping the local landscape.
Background: Hyperparathyroidism is a common endocrinopathy characterised by the formation of parathyroid tumours. In this study, we determine the role of the recently identified gene, HRPT2, in ...parathyroid tumorigenesis. Methods: Mutation analysis of HRPT2 was undertaken in 60 parathyroid tumours: five HPT-JT, three FIHP, three MEN 1, one MEN 2A, 25 sporadic adenomas, 17 hyperplastic glands, two lithium associated tumours, and four sporadic carcinomas. Loss of heterozygosity at 1q24-32 was performed on a subset of these tumours. Results:HRPT2 somatic mutations were detected in four of four sporadic parathyroid carcinoma samples, and germline mutations were found in five of five HPT-JT parathyroid tumours (two families) and two parathyroid tumours from one FIHP family. One HPT-JT tumour with germline mutation also harboured a somatic mutation. In total, seven novel and one previously reported mutation were identified. “Two-hits” (double mutations or one mutation and loss of heterozygosity at 1q24-32) affecting HRPT2 were found in two sporadic carcinomas, two HPT-JT-related and two FIHP related tumours. Conclusions: The results in this study support the role of HRPT2 as a tumour suppressor gene in sporadic parathyroid carcinoma, and provide further evidence for HRPT2 as the causative gene in HPT-JT, and a subset of FIHP. In light of the strong association between mutations of HRPT2 and sporadic parathyroid carcinoma demonstrated in this study, it is hypothesised that HRPT2 mutation is an early event that may lead to parathyroid malignancy and suggest intragenic mutation of HRPT2 as a marker of malignant potential in both familial and sporadic parathyroid tumours.
Mg and Mg+ concentration fields in the upper mesosphere/lower thermosphere (UMLT) region are retrieved from SCIAMACHY/Envisat limb measurements of Mg and Mg+ dayglow emissions using a 2-D tomographic ...retrieval approach. The time series of monthly mean Mg and Mg+ number density and vertical column density in different latitudinal regions are presented. Data from the limb mesosphere-thermosphere mode of SCIAMACHY/Envisat are used, which cover the 50 to 150 km altitude region with a vertical sampling of approximately 3.3 km and latitudes up to 82 degree . The high latitudes are not observed in the winter months, because there is no dayglow emission during polar night. The measurements were performed every 14 days from mid-2008 until April 2012. Mg profiles show a peak at around 90 km altitude with a density between 750 cm-3 and 1500 cm-3. Mg does not show strong seasonal variation at latitudes below 40 degree . For higher latitudes the density is lower and only in the Northern Hemisphere a seasonal cycle with a summer minimum is observed. The Mg+ peak occurs 5-15 km above the neutral Mg peak altitude. These ions have a significant seasonal cycle with a summer maximum in both hemispheres at mid and high latitudes. The strongest seasonal variations of Mg+ are observed at latitudes between 20 and 40 degree and the density at the peak altitude ranges from 500 cm-3 to 4000 cm-3. The peak altitude of the ions shows a latitudinal dependence with a maximum at mid latitudes that is up to 10 km higher than the peak altitude at the equator. The SCIAMACHY measurements are compared to other measurements and WACCM model results. The WACCM results show a significant seasonal variability for Mg with a summer minimum, which is more clearly pronounced than for SCIAMACHY, and globally a higher peak density than the SCIAMACHY results. Although the peak density of both is not in agreement, the vertical column density agrees well, because SCIAMACHY and WACCM profiles have different widths. The agreement between SCIAMACHY and WACCM results is much better for Mg+ with both showing the same seasonality and similar peak density. However, there are also minor differences, e.g. WACCM showing a nearly constant altitude of the Mg+ layer's peak density for all latitudes and seasons.
This work presents a pH sensor platform combining the high performance of iridium oxide (IrOx) fabricated by cyclic voltammetry with inductively-coupled wireless (ICW) transmission. Data included ...presents flexible potentiometric pH sensors having IrOx as the sensing electrode and a cured Ag/AgCl paste as the pseudo-reference electrode; further investigations concerning performance tailoring via fabrication processes are shown. The fabricated sensors show the best performance with a probe surface area of 1 × 1 mm 2 , electrodeposited for 100 cyclic voltammetry (CV) sweeps, at 100 mV/s. The sensitivity of the fabricated sensor is typically in the range of 65-75 mV/pH, as tested using either pH 4-9 (six points) or 2-10 (five points) buffers. The sensors exhibiting those sensitivities in buffer solutions yielded a response from "artificial sweat" solutions differing by ~0.4-0.8 pH from a commercial glass pH electrode, while limit-of-quantification (LOQ) was measured to be ~0.04-0.08 pH. The sensing electrode shows a response time of less than 2 seconds and minimal hysteresis effects. Cationic interferences from up to 1M Na+ resulted in +3-8 mV/pH changes in sensitivity, depending on solution pH and probe, with minimal effects to LOQ. The performance under different bending conditions (0°, 30° at 55 mm radius, 45° at 37 mm, and 90° at 20 mm) of the flexible sensor probe show negligible variation. Finally, the presented sensors were integrated with an inductively coupled wireless (ICW) communication system for a demonstration of online monitoring. This sensor platform can easily be miniaturized due to a low count of necessary components and absence of onboard energy storage.
We report the discovery of 1.97 ms period gamma-ray pulsations from the 75 minute orbital-period binary pulsar now named PSR J1653−0158. The associated Fermi Large Area Telescope gamma-ray source ...4FGL J1653.6−0158 has long been expected to harbor a binary millisecond pulsar. Despite the pulsar-like gamma-ray spectrum and candidate optical/X-ray associations-whose periodic brightness modulations suggested an orbit-no radio pulsations had been found in many searches. The pulsar was discovered by directly searching the gamma-ray data using the GPU-accelerated Einstein@Home distributed volunteer computing system. The multidimensional parameter space was bounded by positional and orbital constraints obtained from the optical counterpart. More sensitive analyses of archival and new radio data using knowledge of the pulsar timing solution yield very stringent upper limits on radio emission. Any radio emission is thus either exceptionally weak, or eclipsed for a large fraction of the time. The pulsar has one of the three lowest inferred surface magnetic-field strengths of any known pulsar with Bsurf 4 × 107 G. The resulting mass function, combined with models of the companion star's optical light curve and spectra, suggests a pulsar mass 2 M . The companion is lightweight with mass ∼0.01 M , and the orbital period is the shortest known for any rotation-powered binary pulsar. This discovery demonstrates the Fermi Large Area Telescope's potential to discover extreme pulsars that would otherwise remain undetected.
ABSTRACT
Black widows are extreme millisecond pulsar binaries where the pulsar wind ablates their low-mass companion stars. In the optical range, their light curves vary periodically due to the high ...irradiation and tidal distortion of the companion, which allows us to infer the binary parameters. We present simultaneous multiband observations obtained with the HIPERCAM instrument at the 10.4-m GTC telescope for six of these systems. The combination of this five-band (us,gs, rs, is, zs) fast photometer with the world’s largest optical telescope enables us to inspect the light curve range near minima. We present the first light curve for PSR J1641+8049, as well as attain a significant increase in signal to noise and cadence compared with previous publications for the remaining five targets: PSR J0023+0923, PSR J0251+2606, PSR J0636+5129, PSR J0952−0607, and PSR J1544+4937. We report on the results of the light-curve modelling with the Icarus code for all six systems, which reveals some of the hottest and densest companion stars known. We compare the parameters derived with the limited but steadily growing black widow population for which optical modelling is available. We find some expected correlations, such as that between the companion star mean density and the orbital period of the system, which can be attributed to the high number of Roche-lobe filling companions. On the other hand, the positive correlation between the orbital inclination and the irradiation temperature of the companion is puzzling. We propose such a correlation would arise if pulsars with magnetic axis orthogonal to their spin axis are capable of irradiating their companions to a higher degree.
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