Hispanic marketers and agencies are using Second Life to gain experience in creating virtual worlds to appeal to Latinos, who are more likely to play online games than their general-market ...counterparts. Alberto Fulham, for instance, shows visitors around El Dorado, one of six "islands" acquired in Second Life by Vidal Partnership, the biggest independent US Hispanic agency. Vidal's goal is to make El Dorado a place where visitors can indulge in all aspects of Latino culture. This year Omnicom Group's Dieste Harmel & Partners, Dallas, created La Ciudad, a Second Life space where Dieste hopes to greet visitors, show its creative work and perhaps generate new business.
MOBILE VIDEO BOOMS AMONG LATINOS Laura Martinez Ruiz-Velasco
Advertising Age,
04/2007, Letnik:
78, Številka:
17
Trade Publication Article
Latinos' penchant for using mobile phones has not escaped marketers, agencies and broadcasters. They are finding ways to reach Latinos on the move via text messaging or image and video downloading. ...About 15.7 million Hispanics own a mobile phone, and though not all carry devices with video capabilities, carriers and content providers are rushing in. MobiTV, the mobile-video subscription service reaching 2 million subscribers, now offers MobiTV en Español, a combination of Spanish and English channels including Telemundo, Mun2, Azteca America, Sorpresa, ESPN Deportes and History Channel en Español.
Latino publishers are moving beyond the printed page, belatedly embracing the Internet and investing heavily in their Web sites, and adding news, video, photos, music, daily alerts and other ...features. Time Inc's People en Español is relaunching PeopleenEspanol.com this spring with more interactive features and bilingual content. The site recently featured a bilingual package highlighting the magazine's first "100 Most Influential People" ranking. Latina relaunched Latina.com in March 2006 with different content, such as videos and movie trailers. English-language Latina is adding online articles in Spanish to target recent immigrants. Meanwhile, this year, ImpreMedia Digital became an independent subsidiary offering advertisers customized e-mail blasts, online surveys, landing pages, microsites and integrated media packages.
All metazoans depend on the consumption of O
by the mitochondrial oxidative phosphorylation system (OXPHOS) to produce energy. In addition, the OXPHOS uses O
to produce reactive oxygen species that ...can drive cell adaptations
, a phenomenon that occurs in hypoxia
and whose precise mechanism remains unknown. Ca
is the best known ion that acts as a second messenger
, yet the role ascribed to Na
is to serve as a mere mediator of membrane potential
. Here we show that Na
acts as a second messenger that regulates OXPHOS function and the production of reactive oxygen species by modulating the fluidity of the inner mitochondrial membrane. A conformational shift in mitochondrial complex I during acute hypoxia
drives acidification of the matrix and the release of free Ca
from calcium phosphate (CaP) precipitates. The concomitant activation of the mitochondrial Na
/Ca
exchanger promotes the import of Na
into the matrix. Na
interacts with phospholipids, reducing inner mitochondrial membrane fluidity and the mobility of free ubiquinone between complex II and complex III, but not inside supercomplexes. As a consequence, superoxide is produced at complex III. The inhibition of Na
import through the Na
/Ca
exchanger is sufficient to block this pathway, preventing adaptation to hypoxia. These results reveal that Na
controls OXPHOS function and redox signalling through an unexpected interaction with phospholipids, with profound consequences for cellular metabolism.
Microalgae are complex photosynthetic organisms found in marine and freshwater environments that produce valuable metabolites. Microalgae-derived metabolites have gained remarkable attention in ...different industrial biotechnological processes and pharmaceutical and cosmetic industries due to their multiple properties, including antioxidant, anti-aging, anti-cancer, phycoimmunomodulatory, anti-inflammatory, and antimicrobial activities. These properties are recognized as promising components for state-of-the-art cosmetics and cosmeceutical formulations. Efforts are being made to develop natural, non-toxic, and environmentally friendly products that replace synthetic products. This review summarizes some potential cosmeceutical applications of microalgae-derived biomolecules, their mechanisms of action, and extraction methods.
Cardioprotective effect of red wine and grape pomace Muñoz-Bernal, Óscar A.; Coria-Oliveros, Alma J.; de la Rosa, Laura A. ...
Food research international,
February 2021, 2021-Feb, 2021-02-00, 20210201, Letnik:
140
Journal Article
Recenzirano
Display omitted
Several studies have related moderate consumption of red wine with prevention of cardiovascular diseases (CVD). According to epidemiological studies, those regions with high ...consumption of red wine and a Mediterranean diet show a low prevalence of CVD. Such an effect has been attributed to phenolic compounds present in red wines. On the other hand, by-products obtained during winemaking are also a significant source of phenolic compounds but have been otherwise overlooked. The cardioprotective effect of red wine and its byproducts is related to their ability to prevent platelet aggregation, modify the lipid profile, and promote vasorelaxation. Phenolic content and profile seem to play an important role in these beneficial effects. Inhibition of platelet aggregation is dose-dependent and more efficient against ADP. The antioxidant capacity of phenolic compounds from red wine and its by-products, is involved in preventing the generation of ROS and the modification of the lipid profile, to prevent LDL oxidation. Phenolic compounds can also, modulate the activity of specific enzymes to promote NO production and vasorelaxation. Specific phenolic compounds like resveratrol are related to promote NO, and quercetin to inhibit platelet aggregation. Nevertheless, concentration that causes those effects is far from that in red wines. Synergic and additive effects of a mix of phenolic compounds could explain the cardioprotective effects of red wine and its byproducts.
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