Abstract
Forecasting power demand and photovoltaic (PV) power generation is indispensable for the economic operation of electric utility businesses. Herein, robust demand and PV power forecast models ...are proposed that enable electricity companies including new entrants to efficiently forecast from small sample size data by using only published weather forecasts. We further enhance the previously proposed forecast models by using the tensor product spline function to impose smoothing conditions, not only in the seasonal direction but also in the hour direction, thereby constructing effective models that can incorporate multiple explanatory variables. The empirical results of the estimated two-dimensional trends are consistent with the intuitive interpretation, and the validations of the out-of-sample forecast error obtained from the data of nine different areas ensure the high robustness of the proposed model.
A computationally efficient space-time turbo equalization algorithm is derived for frequency-selective multiple-input-multiple-output (MIMO) channels. The algorithm is an extension of the iterative ...equalization algorithm by Reynolds and Wang (see Signal Processing, vol.81, no.5, p.989-995, 2001) for frequency-selective fading channels and of iterative multiuser detection for code-division multiple-access (CDMA) systems by Wang and Poor (see IEEE Trans. Commun., vol.47, p.1046-1061, 1999). The proposed algorithm is implemented as a MIMO detector consisting of a soft-input-soft-output (SISO) linear MMSE detector followed by SISO channel decoders for the multiple users. The detector first forms a soft replica of each composite interfering signal using the log likelihood ratio (LLR), fed back from the SISO channel decoders, of the transmitted coded symbols and subtracts it from the received signal vector. Linear adaptive filtering then takes place to suppress the interference residuals: filter taps are adjusted based on the minimum mean square error (MMSE) criterion. The LLR is then calculated for adaptive filter output. This process is repeated in an iterative fashion to enhance signal-detection performance. This paper also discusses the performance sensitivity of the proposed algorithm to channel-estimation error. A channel-estimation scheme is introduced that works with the iterative MIMO equalization process to reduce estimation errors.
Application of nickel‑titanium (NiTi) alloys to medical implant devices is increasing due to their unique characteristics. However, many reports show adverse effects of corrosion of the alloys due to ...implantation in human body. To ensure good biocompatibility in the human body, fluorine-doped amorphous carbon (a-C:H:F) coating is a promising candidate. Generally, a-C:H:F coating shows poor adhesion on metallic alloys, so that silicon-incorporated interlayer is introduced between a-C:H:F and metallic alloys. However, this membrane design has a risk of delamination at the outermost interface (a-C:H:F//interlayer), and also there is a practical problem that coating time becomes long because the deposition process in multiple stages is required. Here we develop silicon and fluorine doped amorphous carbon (a-C:H:Si:F) film which exhibits high adhesion and excellent biocompatibility. One of the a-C:H:Si:F films “C2H2-doped”, which was deposited using a mixture of TMS, C2H2 and C3F8, showed higher adhesive strength than a-C:H:F with Si-interlayer and the same number of adhesive platelets and leukocytes as a-C:H:F. This result demonstrated that a single film with both adhesion of Si-interlayer and biocompatibility of a-C:H:F was fabricated. Furthermore, this a-C:H:Si:F coating can be anticipated as an effective film coating method in a practical point of view, because the film deposition is completed in one process.
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•Single-layered silicon and fluorine doped amorphous carbon (a-C:H:Si:F) films were fabricated from TMS, C3F8 and C2H2.•The properties and structures of a-C:H:Si:F films were controlled by source gas flow rate.•The a-C:H:Si:F film whose Si and F was optimally controlled showed both excellent adhesive strength and biocompatibility.
This study examined the effects of regular post-exercise cold application on muscular and vascular adaptations induced by moderate-intensity resistance training. 14 male subjects participated in ...resistance training: 5 sets of 8 wrist-flexion exercises at workload of 70-80% of the single repetition maximum, 3 times a week for 6 weeks. 7 subjects immersed their experimental forearms in cold water (10±1°C) for 20 min after wrist-flexion exercises (cooled group), and the other 7 served as control subjects (noncooled group). Measurements were taken before and after the training period; wrist-flexor thickness, brachial-artery diameter, maximal muscle strength, and local muscle endurance were measured in upper extremities. Wrist-flexor thicknesses of the experimental arms increased after training in both groups, but the extent of each increase was significantly less in the cooled group compared with the noncooled group. Maximal muscle strength and brachial-artery diameter did not increase in the cooled group, while they increased in the noncooled group. Local muscle endurance increased in both groups, but the increase in the cooled group tended to be lower compared to the noncooled group. Regular post-exercise cold application to muscles might attenuate muscular and vascular adaptations to resistance training.
Given the complexity and heterogeneity of the genomic architecture underlying schizophrenia, molecular analyses of these patients with defined and large effect-size genomic defects could provide ...valuable clues. We established human-induced pluripotent stem cells from two schizophrenia patients with the 22q11.2 deletion (two cell lines from each subject, total of four cell lines) and three controls (total of four cell lines). Neurosphere size, neural differentiation efficiency, neurite outgrowth, cellular migration and the neurogenic-to-gliogenic competence ratio were significantly reduced in patient-derived cells. As an underlying mechanism, we focused on the role of DGCR8, a key gene for microRNA (miRNA) processing and mapped in the deleted region. In mice, Dgcr8 hetero-knockout is known to show a similar phenotype of reduced neurosphere size (Ouchi et al., 2013). The miRNA profiling detected reduced expression levels of miRNAs belonging to miR-17/92 cluster and miR-106a/b in the patient-derived neurospheres. Those miRNAs are reported to target p38α, and conformingly the levels of p38α were upregulated in the patient-derived cells. p38α is known to drive gliogenic differentiation. The inhibition of p38 activity by SB203580 in patient-derived neurospheres partially restored neurogenic competence. Furthermore, we detected elevated expression of GFAP, a gliogenic (astrocyte) marker, in postmortem brains from schizophrenia patients without the 22q11.2 deletion, whereas inflammation markers (IL1B and IL6) remained unchanged. In contrast, a neuronal marker, MAP2 expressions were decreased in schizophrenia brains. These results suggest that a dysregulated balance of neurogenic-to-gliogenic competence may underlie neurodevelopmental disorders such as schizophrenia.
Summary Objective SIRT6, a member of the sirtuin family of nicotinamide adenine dinucleotide (NAD+ )-dependent protein deacetylases, has been implicated as a key factor in aging-related diseases. ...However, the role of SIRT6 in chondrocytes has not been fully explored. The purpose of this study was to examine the role of SIRT6 in human chondrocytes by inhibiting SIRT6 in vitro. Design First, the localization of SIRT6 and proliferation cell nuclear antigen (PCNA) in human cartilages was examined by immunohistochemistry. Next, SIRT6 was depleted by RNA interference (RNAi), and the effect of SIRT6 depletion on changes in gene expression, protein levels, proliferation, and senescence in human chondrocytes was assessed. Furthermore, to detect DNA damage and telomere dysfunction, γH2AX foci and telomere dysfunction-induced foci (TIFs) were examined using immunofluorescence microscopy. The protein levels of two mediators for DNA damage induced-senescence, p16 and p21, were examined by western blotting. Results Immunohistochemical analysis showed SIRT6 was preferentially expressed in the superficial zone chondrocytes and PCNA-positive cluster-forming chondrocytes in the osteoarthritic cartilage tissue samples. Real-time PCR analysis showed that matrix metalloproteinase 1 ( MMP-1 ) and MMP-13 mRNA were significantly increased by SIRT6 inhibition. Moreover, SIRT6 inhibition significantly reduced proliferation and increased senescence associated β-galactosidase (SA-β-Gal)-positive chondrocytes; it also led to increased p16 levels. Immunofluorescence microscopy showed that γH2AX foci and TIFs were increased by SIRT6 inhibition. Conclusion Depletion of SIRT6 in human chondrocytes caused increased DNA damage and telomere dysfunction, and subsequent premature senescence. These findings suggest that SIRT6 plays an important role in the regulation of senescence of human chondrocytes.
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