The dependence of the polarization fraction p on total intensity I in polarized submillimeter emission measurements is typically parameterized as p ∝ I− ( ≤ 1) and used to infer dust grain alignment ...efficiency in star-forming regions, with an index = 1 indicating near-total lack of alignment of grains with the magnetic field. In this work, we demonstrate that the non-Gaussian noise characteristics of the polarization fraction may produce apparent measurements of ∼ 1 even in data with significant signal-to-noise in Stokes Q, U, and I emission, and so with robust measurements of polarization angle. We present a simple model demonstrating this behavior and propose a criterion by which well-characterized measurements of the polarization fraction may be identified. We demonstrate that where our model is applicable, can be recovered by fitting the p-I relationship with the mean of the Rice distribution without statistical debiasing of the polarization fraction. We apply our model to JCMT BISTRO Survey POL-2 850 m observations of three clumps in the Ophiuchus molecular cloud, finding that in the externally illuminated Oph A region, 0.34, while in the more isolated Oph B and C, despite their differing star formation histories, ∼ 0.6-0.7. Our results thus suggest that dust grain alignment in dense gas is more strongly influenced by the incident interstellar radiation field than by star formation history. We further find that grains may remain aligned with the magnetic field at significantly higher gas densities than has previously been believed, thus allowing investigation of magnetic field properties within star-forming clumps and cores.
Background
Patients with favorable-risk prostate cancer on active surveillance (AS) are strictly followed for safer execution. Repeat protocol biopsy is essential for evaluating cancer ...aggressiveness. However, the acceptance rate of repeat biopsy is not high enough because of the burdens of biopsy. We assessed the impact of complications after the initial biopsy on repeat protocol biopsy at 1 year using data from the Prostate Cancer Research International: Active Surveillance (PRIAS)-JAPAN study.
Methods
We performed a retrospective analysis using a prospective cohort in the PRIAS-JAPAN study. Patients with favorable-risk prostate cancer (
n
= 856) who consented to participate in the PRIAS-JAPAN study from 2010 to 2018 were enrolled. Follow-up evaluations included regular prostate-specific antigen, digital rectal examination and biopsy. Rates of complications after biopsies and repeat protocol biopsy non-acceptance rate at 1 year were reported. Logistic regression analysis explored the association between the complications after the initial biopsy and repeat protocol biopsy non-acceptance.
Results
Altogether, 759 patients (88.7%) actually proceeded to protocol at 1 year. Repeat protocol biopsy non-acceptance rate at 1 year was 14.9%. Regarding complications after the initial biopsy, hematuria (
p
= 0.028) and pain (
p
< 0.001) rates were significantly higher in the repeat biopsy non-acceptance group, but infection (
p
= 0.056) and hematospermia (
p
= 0.337) rates were not different. On multivariate logistic regression analysis, pain was a significant predictor for repeat protocol biopsy non-acceptance (odds ratio 4.68, 95% confidence interval 1.864–11.75;
p
= 0.001).
Conclusions
Pain at the initial biopsy negatively impacts patients’ compliance with further protocol biopsies during AS.
Abstract
The Galactic global magnetic field is thought to play a vital role in shaping Galactic structures such as spiral arms and giant molecular clouds. However, our knowledge of magnetic field ...structures in the Galactic plane at different distances is limited, as measurements used to map the magnetic field are the integrated effect along the line of sight. In this study, we present the first ever tomographic imaging of magnetic field structures in a Galactic spiral arm. Using optical stellar polarimetry over a
17
′
×
10
′
field of view, we probe the Sagittarius spiral arm. Combining these data with stellar distances from the Gaia mission, we can isolate the contributions of five individual clouds along the line of sight by analyzing the polarimetry data as a function of distance. The observed clouds include a foreground cloud (
d
< 200 pc) and four clouds in the Sagittarius arm at 1.23, 1.47, 1.63, and 2.23 kpc. The column densities of these clouds range from 0.5 to 2.8 × 10
21
cm
−2
. The magnetic fields associated with each cloud show smooth spatial distributions within their observed regions on scales smaller than 10 pc and display distinct orientations. The position angles projected on the plane of the sky, measured from the Galactic north to the east, for the clouds in increasing order of distance are 135°, 46°, 58°, 150°, and 40°, with uncertainties of a few degrees. Notably, these position angles deviate significantly from the direction parallel to the Galactic plane.
To assess patient-reported outcomes after open radical prostatectomy, laparoscopic radical prostatectomy and permanent prostate brachytherapy.
patient-reported outcomes were evaluated using Expanded ...Prostate Cancer Index Composite scores at baseline and 1, 3, 6, 12 and 36 months after treatment, respectively, using differences from baseline scores.
Urinary function was the same in the three groups at baseline, but worse after surgery than after permanent prostate brachytherapy until 12 months, and similar after open radical prostatectomy and permanent prostate brachytherapy and better than after laparoscopic radical prostatectomy at 36 months. Urinary bother was significantly worse at 1 month after surgery, but better after open radical prostatectomy than after permanent prostate brachytherapy and laparoscopic radical prostatectomy at 3 months, after which symptoms improved gradually in all groups. Obstructive/irritative symptoms were worse after permanent prostate brachytherapy than after open radical prostatectomy at 36 months, and worse after laparoscopic radical prostatectomy until 6 months. Urinary incontinence was worse after surgery, particularly after 1 month. This symptom returned to the baseline level at 12 months after open radical prostatectomy, but recovery after laparoscopic radical prostatectomy was slower. Bowel function after permanent prostate brachytherapy was significantly worse than after surgery at 1 month and this continued until 6 months. Bowel bother was slightly worse at 3 and 6 months after permanent prostate brachytherapy compared to these time points after surgery.
Urinary function and bother were worst after laparoscopic radical prostatectomy, especially in the early postoperative phase, whereas urinary obstructive/irritative symptom, bowel function and bother were worse after permanent prostate brachytherapy. These findings are useful and informative for the treatment of patients with prostate cancer.
Abstract
Measurement of magnetic field strengths in a molecular cloud is essential for determining the criticality of magnetic support against gravitational collapse. In this paper, as part of the ...JCMT BISTRO survey, we suggest a new application of the Davis–Chandrasekhar–Fermi (DCF) method to estimate the distribution of magnetic field strengths in the OMC-1 region. We use observations of dust polarization emission at 450 and 850
μ
m, and C
18
O (3–2) spectral line data obtained with the JCMT. We estimate the volume density, the velocity dispersion, and the polarization angle dispersion in a box, 40″ × 40″ (5×5 pixels), which moves over the OMC-1 region. By substituting three quantities in each box with the DCF method, we get magnetic field strengths over the OMC-1 region. We note that there are very large uncertainties in the inferred field strengths, as discussed in detail in this paper. The field strengths vary from 0.8 to 26.4 mG, and their mean value is about 6 mG. Additionally, we obtain maps of the mass-to-flux ratio in units of a critical value and the Alfvén Mach number. The central parts of the BN–KL and South (S) clumps in the OMC-1 region are magnetically supercritical, so the magnetic field cannot support the clumps against gravitational collapse. However, the outer parts of the region are magnetically subcritical. The mean Alfvén Mach number is about 0.4 over the region, which implies that the magnetic pressure exceeds the turbulent pressure in the OMC-1 region.
Abstract
Objectives
This study aimed to evaluate whether oncological outcomes of radical prostatectomy differ depending on adherence to the criteria in patients who opt for active surveillance.
...Materials and methods
We retrospectively reviewed the data of 1035 patients enrolled in a prospective cohort of the PRIAS-JAPAN study. After applying the exclusion criteria, 136 of 162 patients were analyzed. Triggers for radical prostatectomy due to pathological reclassification on repeat biopsy were defined as on-criteria. Off-criteria triggers were defined as those other than on-criteria triggers. Unfavorable pathology on radical prostatectomy was defined as pathological ≥T3, ≥GS 4 + 3 and pathological N positivity. We compared the pathological findings on radical prostatectomy and prostate-specific antigen recurrence-free survival between the two groups. The off-criteria group included 35 patients (25.7%), half of whom received radical prostatectomy within 35 months.
Results
There were significant differences in median prostate-specific antigen before radical prostatectomy between the on-criteria and off-criteria groups (6.1 vs. 8.3 ng/ml, P = 0.007). The percentage of unfavorable pathologies on radical prostatectomy was lower in the off-criteria group than that in the on-criteria group (40.6 vs. 31.4%); however, the differences were not statistically significant (P = 0.421). No significant difference in prostate-specific antigen recurrence-free survival was observed between the groups during the postoperative follow-up period (median: 36 months) (log-rank P = 0.828).
Conclusions
Half of the off-criteria patients underwent radical prostatectomy within 3 years of beginning active surveillance, and their pathological findings were not worse than those of the on-criteria patients.
Criteria adherence was not associated with unfavorable pathology with regard to radical prostatectomy in patients who opt for active surveillance.
Objectives
To compare the medical costs of active surveillance with those of robot‐assisted laparoscopic prostatectomy, brachytherapy, intensity‐modulated radiation therapy, and hormone therapy for ...low‐risk prostate cancer.
Methods
The costs of protocol biopsies performed in the first year of surveillance (between January 2010 and June 2020) and those of brachytherapy and radiation therapy performed between May 2019 and June 2020 at the Kagawa University Hospital were analyzed. Hormone therapy costs were assumed to be the costs of luteinizing hormone‐releasing hormone analogs for over 5 years. Active surveillance‐eligible patients were defined based on the following: age <74 years, ≤T2, Gleason score ≤6, prostate‐specific antigen level ≤10 ng/ml, and 1–2 positive cores. We estimated the total number of active surveillance‐eligible patients in Japan based on the Japan Study Group of Prostate Cancer (J‐CAP) study and the 2017 cancer statistical data. We then calculated the 5‐year treatment costs of active surveillance‐eligible patients using the J‐CAP and PRIAS‐JAPAN study data.
Results
In 2017, number of active surveillance‐eligible patients in Japan was estimated to be 2808. The 5‐year total costs of surveillance, prostatectomy, brachytherapy, radiation therapy, and hormone therapy were 1.65, 14.0, 4.61, 4.04, and 5.87 million United States dollar (USD), respectively. If 50% and 100% of the patients in each treatment group had opted for active surveillance as the initial treatment, the total treatment cost would have been reduced by USD 6.89 million (JPY 889 million) and USD 13.8 million (JPY 1.78 billion), respectively.
Conclusion
Expanding active surveillance to eligible patients with prostate cancer helps save medical costs.
Abstract
Optical stellar polarimetry in the Perseus molecular cloud direction is known to show a fully mixed bimodal distribution of position angles across the cloud. We study the Gaia trigonometric ...distances to each of these stars and reveal that the two components in position angles trace two different dust clouds along the line of sight. One component, which shows a polarization angle of −37.°6 ± 35.°2 and a higher polarization fraction of 2.0 ± 1.7 %, primarily traces the Perseus molecular cloud at a distance of 300 pc. The other component, which shows a polarization angle of +66.°8 ± 19.°1 and a lower polarization fraction of 0.8 ± 0.6 %, traces a foreground cloud at a distance of 150 pc. The foreground cloud is faint, with a maximum visual extinction of ≤1 mag. We identify that foreground cloud as the outer edge of the Taurus molecular cloud. Between the Perseus and Taurus molecular clouds, we identify a lower-density ellipsoidal dust cavity with a size of 100–160 pc. This dust cavity is located at
l
= 170°,
b
= −20°, and
d
= 240 pc, which corresponds to an H
I
shell generally associated with the Per OB2 association. The two-component polarization signature observed toward the Perseus molecular cloud can therefore be explained by a combination of the plane-of-sky orientations of the magnetic field both at the front and at the back of this dust cavity.
The study was performed to examine patient-reported outcomes (PROs) in the 1
year after surgery and the institutional learning curve after the introduction of robot-assisted radical prostatectomy ...(RARP).
The subjects were 320 consecutive patients who underwent RARP from 2014 to 2018. These cases were divided into three groups treated in the early, middle, and late periods, with about 100 cases in each. PROs were recorded using the Expanded Prostate Cancer Index Composite (EPIC).
There were no significant differences among the early, middle, and late periods based on EPIC scores. Urinary function and bother decreased in the 1
month after surgery, and gradually recovered thereafter. However, urinary function was significantly worse in the 1
year after surgery than at baseline. Urinary function and bother were better in patients treated with nerve-sparing surgery, and in nerve-sparing cases, urinary function and bother were best in the early period and worst in the late period. These cases also had the best score for sexual function in the early period, but sexual bother was worst in the early period. In contrast, in cases treated without nerve-sparing surgery, urinary function and bother were best in the late period and worst in the early period, although without significant differences.
The functional results of this study based on PROs are useful for providing information for patients. Interestingly, the institutional learning curves for RARP differed in cases that did and did not undergo a nerve-sparing procedure.
Background
This study investigated the clinical impact of carcinoma in situ (CIS) in intravesical Bacillus Calmette-Guérin (BCG) therapy for patients with non-muscle-invasive bladder cancer (NMIBC).
...Methods
This study retrospectively evaluated 3035 patients who were diagnosed with NMIBC and treated by intravesical BCG therapy between 2000 and 2019 at 31 institutions. Patients were divided into six groups according to the presence of CIS as follows: low-grade Ta without concomitant CIS, high-grade Ta without concomitant CIS, high-grade Ta with concomitant CIS, high-grade T1 without concomitant CIS, high-grade T1 with concomitant CIS, and pure CIS (without any papillary lesion). The endpoints were recurrence- and progression-free survival after the initiation of BCG therapy. We analyzed to identify factors associated with recurrence and progression.
Results
At a median follow-up of 44.4 months, recurrence and progression were observed in 955 (31.5%) and 316 (10.4%) patients, respectively. Comparison of six groups using univariate and multivariate analysis showed no significant association of CIS. However, CIS in the prostatic urethra was an independent factors associated with progression.
Conclusion
Concomitant CIS did not show a significant impact in the analysis of Ta and T1 tumors which were treated using intravesical BCG. Concomitant CIS in the prostatic urethra was associated with high risk of progression. Alternative treatment approaches such as radical cystectomy should be considered for patients with NMIBC who have a risk of progression.
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