Objective: The present study evaluated distinct facets of impulsivity related to cardiometabolic risk (CMR) to identify specific behavioral mechanisms driving these relationships. Method: Community ...adults (N = 1,295) between 30 and 54 years old (53% female, 84% White) completed a battery of impulsivity measures, reported their engagement in health behaviors over the past week (i.e., cigarette smoking, alcohol use, physical activity, and dietary intake), and were assessed for CMR factors (i.e., blood pressure, insulin resistance, adiposity, and blood lipids). Structural equation modeling was used to estimate previously established hierarchical models of distinct facets of impulsivity and CMR. Indirect effects through the observed health behaviors were examined for each association between the latent impulsivity factors identified and the latent CMR factor. Results: Neuroticism/negative emotionality was the only latent impulsivity factor directly related to heightened CMR (β = 0.09, 95% confidence interval CI 0.01, 0.16, p = .020). Extraversion/positive emotionality indirectly related to lower CMR through greater physical activity (β = −0.04, 95% CI −0.06, −0.02, p < .001), and measures of inhibition (β = 0.02, 95% CI 0.001, 0.04, p = .045) and delay discounting (β = 0.08, 95% CI 0.001, 0.15, p = .049) indirectly related to CMR through saturated fat intake. Conclusions: These findings indicate that distinct facets of impulsivity differentially relate to CMR through varied behavioral pathways and identify physical activity and saturated fat intake as being particularly important health behaviors to target when tailoring treatment approaches to the unique behavioral characteristics of individuals high on certain facets of impulsivity.
The Transiting Exoplanet Survey Satellite TESS has begun a new age of exoplanet discoveries around bright host stars. We present the discovery of HD 1397b (TOI-120.01), a giant planet in an 11.54-day ...eccentric orbit around a bright (V = 7.9) G-type subgiant. We estimate both host star and planetary parameters consistently using EXOFASTv2 based on TESS time-series photometry of transits and radial velocity measurements with CORALIE and MINERVA-Australis. We also present high angular resolution imaging with NaCo to rule out any nearby eclipsing binaries. We find that HD 1397b is a Jovian planet, with a mass of 0.415 ± 0.020 MJ and a radius of 1.026 ± 0.026 RJ. Characterising giant planets in short-period eccentric orbits, such as HD 1397b, is important for understanding and testing theories for the formation and migration of giant planets as well as planet-star interactions.
The Galactic center supermassive black hole Sagittarius A* (Sgr A*) is one of the most promising targets to study the dynamics of black hole accretion and outflow via direct imaging with very long ...baseline interferometry (VLBI). At 3.5 mm (86 GHz), the emission from Sgr A* is resolvable with the Global Millimeter VLBI Array (GMVA). We present the first observations of Sgr A* with the phased Atacama Large Millimeter/submillimeter Array (ALMA) joining the GMVA. Our observations achieve an angular resolution of ∼87 as, improving upon previous experiments by a factor of two. We reconstruct a first image of the unscattered source structure of Sgr A* at 3.5 mm, mitigating the effects of interstellar scattering. The unscattered source has a major-axis size of 120 34 as (12 3.4 Schwarzschild radii) and a symmetrical morphology (axial ratio of ), which is further supported by closure phases consistent with zero within 3 . We show that multiple disk-dominated models of Sgr A* match our observational constraints, while the two jet-dominated models considered are constrained to small viewing angles. Our long-baseline detections to ALMA also provide new constraints on the scattering of Sgr A*, and we show that refractive scattering effects are likely to be weak for images of Sgr A* at 1.3 mm with the Event Horizon Telescope. Our results provide the most stringent constraints to date for the intrinsic morphology and refractive scattering of Sgr A*, demonstrating the exceptional contribution of ALMA to millimeter VLBI.
Energetic flares are observed in the Galactic supermassive black hole Sagittarius A* from radio to X-ray wavelengths. On a few occasions, simultaneous flares have been detected in IR and X-ray ...observations, but clear counterparts at longer wavelengths have not been seen. We present a flare observed over several hours on 2006 July 17 with the Chandra X-Ray Observatory, the Keck II telescope, the Caltech Submillimeter Observatory, and the Submillimeter Array. All telescopes observed strong flare events, but the submillimeter peak is found to occur nearly 100 minutes after the X-ray peak. Submillimeter polarization data show linear polarization in the excess flare emission, increasing from 9% to 17% as the flare passes through its peak, consistent with a transition from optically thick to thin synchrotron emission. The temporal and spectral behavior of the flare require that the energetic electrons responsible for the emission cool faster than expected from their radiative output. This is consistent with adiabatic cooling in an expanding emission region, with X-rays produced through self-Compton scattering, although not consistent with the simplest model of such expansion. We also present a submillimeter flare that followed a bright IR flare on 2005 July 31. Compared to 2006, this event had a larger peak IR flux and similar submillimeter flux, but it lacked measurable X-ray emission. It also showed a shorter delay between the IR and submillimeter peaks. Based on these events we propose a synchrotron and self-Compton model to relate the submillimeter lag and the variable IR/X-ray luminosity ratio.
Stealth technology for wind turbines PINTO, J; MATTHEWS, J. C. G; SARNO, G. C
IET radar, sonar & navigation,
02/2010, Letnik:
4, Številka:
1
Journal Article
Recenzirano
The current generation of on and off-shore three-bladed horizontal axis wind turbines have radar signatures consistent with their often very large physical size and, hence, considerable potential to ...reduce the ability of ground-based radars to detect targets in the vicinity of the farm. In addition, the increasing number of offshore wind farm projects proposed has the potential to cause interference to marine radars such as coastal vessel traffic services and those on-board vessels for navigational purposes. This study considers the options available for the reduction of turbine radar signature and presents solutions for each of the main external turbine components. The radar signature reduction approaches are based on existing technologies developed for aerospace stealth applications. However, the realisation of these for the purposes of reducing wind turbine radar signatures is a novel development, particularly in the solutions proposed. The reduction of wind turbine-induced radar interference is a growing area of research.
Interleukin (IL)-37, an antiinflammatory IL-1 family cytokine, is a key suppressor of innate immunity. IL-37 signaling requires the heterodimeric IL-18R1 and IL-1R8 receptor, which is abundantly ...expressed in the gastrointestinal tract. Here we report a 4-mo-old male from a consanguineous family with a homozygous loss-of-function
mutation. The patient presented with persistent diarrhea and was found to have infantile inflammatory bowel disease (I-IBD). Patient cells showed increased intracellular IL-37 expression and increased proinflammatory cytokine production. In cell lines, mutant IL-37 was not stably expressed or properly secreted and was thus unable to functionally suppress proinflammatory cytokine expression. Furthermore, induced pluripotent stem cell-derived macrophages from the patient revealed an activated macrophage phenotype, which is more prone to lipopolysaccharide and IL-1β stimulation, resulting in hyperinflammatory tumor necrosis factor production. Insights from this patient will not only shed light on monogenic contributions of I-IBD but may also reveal the significance of the IL-18 and IL-37 axis in colonic homeostasis.
Interleukin-2, which conveys essential signals for immunity, operates through a heterotrimeric receptor. Here we identify human interleukin-2 receptor (IL-2R) β chain (
) gene defects as a cause of ...life-threatening immune dysregulation. We report three homozygous mutations in the
gene of eight individuals from four consanguineous families that cause disease by distinct mechanisms. Nearly all patients presented with autoantibodies, hypergammaglobulinemia, bowel inflammation, dermatological abnormalities, lymphadenopathy, and cytomegalovirus disease. Patient T lymphocytes lacked surface expression of IL-2Rβ and were unable to respond to IL-2 stimulation. By contrast, natural killer cells retained partial IL-2Rβ expression and function. IL-2Rβ loss of function was recapitulated in a recombinant system in which
mutations caused reduced surface expression and IL-2 binding. Stem cell transplant ameliorated clinical symptoms in one patient; forced expression of wild-type IL-2Rβ also increased the IL-2 responsiveness of patient T lymphocytes in vitro. Insights from these patients can inform the development of IL-2-based therapeutics for immunological diseases and cancer.
Background
The underlying mechanisms of chemotherapy-induced gastrointestinal (GI) symptoms are poorly researched. This study characterised the nature, frequency, severity and treatable causes for GI ...symptoms prospectively in patients undergoing chemotherapy for GI malignancy.
Methods
Patients receiving chemotherapy for a GI malignancy were assessed pre-chemotherapy, then monthly for 1 year using the Gastrointestinal Symptom Rating Scale, a validated patient-reported outcome measure. Patients with new, troublesome GI symptoms were offered investigations to diagnose the cause(s). Their oncologist was alerted when investigations were abnormal.
Results
A total of 241 patients, 60% male, median age 63 years (range 30–88), were enrolled; 122 patients were withdrawn, 93%, because of progressive disease or death. During the study, > 20% patients reported chronic faecal incontinence and > 10% reported moderate or severe problems with taste, dysphagia, belching, heartburn, early satiety, appetite, nausea, abdominal cramps, peri-rectal pain, rectal flatulence, borborygmi, urgency of defecation or tenesmus. Thirty percent reported continuing passage of hard stools and 30% on-going diarrhoea. Moderate or severe fatigue affected 40% participants at its peak and persisted in 15% at 1 year. Toxicity dictated change in chemotherapy for 13–29% patients/month. Common Terminology Criteria for Adverse Events underestimated gastrointestinal morbidity. Pre-chemotherapy screening identified previously undiagnosed pathology: exocrine pancreatic insufficiency (9%), vitamin B
12
deficiency (12%) and thyroid dysfunction (20%). Patients often refused investigations to diagnose their chemotherapy-induced symptoms; however, for every three investigations performed, one treatable cause was diagnosed: particularly small intestinal bacterial overgrowth (54%), bile acid malabsorption (43%), previously not described after chemotherapy, and unsuspected urinary tract infection (17%).
Conclusions
Patients undergoing chemotherapy for GI malignancy commonly have difficult GI symptoms requiring active management which does not occur routinely. The underlying causes for these symptoms are often treatable or curable. Randomised trials are urgently needed to show whether timely investigation and treatment of symptoms improve quality of life and survival.
Trial registration
ClinicalTrials.gov
Identifier: NCT02121626
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