Geotechnical assets are vital for the efficiency of transportation corridors. Geotechnical monitoring can be a powerful tool for an effective maintenance of transportation assets and for safety ...purposes. Thanks to the technological evolution that has occurred during recent years, several monitoring technologies are now available to perform geotechnical monitoring. Ranging from remote satellite systems to contact instrumentation, it is now possible to perform a multi-scale approach in space and time, thus effectively supporting management and decision making actions. In this paper, three main categories of geotechnical monitoring are considered on the basis of the “monitoring purpose”: knowledge monitoring, control monitoring and emergency monitoring. STN (space–time-need) diagrams are proposed as a simple and useful graphic tool for the design of an effective monitoring plan that accounts for both the technical capabilities of the available monitoring technologies and the specific monitoring needs. Effective monitoring programs, suitable tools for data collection, management and processing combined with efficient models to support decision making leads to “Smart Geotechnical Asset Management” (SGAM). SGAM is a program that takes advantage of sensors collecting data in order to make risk assessment continuously updated over time.
An integrated approach to the geomechanical characterization of coastal sea cliffs was applied at Mt. Pucci (Gargano promontory, Southern Italy) by performing field-based geomechanical investigations ...and remote geostructural investigations via a terrestrial laser scanner (TLS). The consistency of the integrated techniques allowed to achieve a comprehensive and affordable characterization of the main joint sets on the sea cliff slope. The observed joint sets were considered to evaluate the proneness of the slope to rock failures by attributing safety factor (SF) values to the topple- and wedge-prone rock blocks under three combined or independent triggering conditions: (a) hydrostatic water pressures within the joints, (b) seismic action, and (c) strength reduction due to weathering of the joint surfaces. The combined action of weathering and water pressures within the joints was also considered, resulting in a significant decrease in the stability. Furthermore, remote survey analyses via InfraRed Thermography (IRT) and Ground Based Synthetic Aperture Radar Interferometry (GBInSAR) were performed to evaluate the role of the surveyed joint sets in inducing instabilities in the Mt. Pucci sea cliff. The results from the remote surveys: (i) GBInSAR monitoring revealed permanent displacements coupled to cyclic daily displacements, these last ones detected in certain sectors of the cliff wall; (ii) the thermal images allowed us to identify anomalies that correspond well to the main joints and to the slope material released due to recent collapses.
On August 16th, 2018, a Mw 5.1 earthquake struck the Molise region (central Italy), inducing 84 earthquake-triggered landslides that predominantly involved soil covers of clayey materials and flysch ...on gently dipping slopes. To quantify the spatiotemporal landslide activity in the months immediately after the earthquake, a differential SAR interferometry (DInSAR) analysis was performed for a time span from 2 years before to one year after the earthquake, recognising both first-time and reactivated landslides. The results showed a clear increase in landslide activity following the low-magnitude earthquake with respect to the activities recorded in the same months of the previous years. Several coherent landslides (earth slides and earth flows) were observed following seasonally recurrent rainfall events. Such increases were observed for both reactivated and first-time landslides, showing decreases in inactive periods and activity over longer periods. Furthermore, the spatial density distribution of the landslides was investigated in the postseismic time interval along transects perpendicular and parallel to the direction of the tectonic element responsible for the seismic event. An asymmetrical distribution was deduced parallel to the fault strike with a higher number of landslides located inside the compressional sector according to a strike-slip faulting mechanism.
Background Because the efficacy of carboplatin and cisplatin in the treatment of advanced non–small-cell lung cancer (NSCLC) has not been proven to be equivalent, an individual patient data ...meta-analysis comparing the two treatments was performed. Methods Randomized trials comparing carboplatin to cisplatin in first-line treatment of advanced NSCLC were identified and their electronic databases obtained. A general variance-based method was used to estimate the summary hazard ratios (HRs), odds ratios (ORs), and their 95% confidence intervals (CIs) for mortality, objective response, and toxicity. Cochran's chi-square test (Q test) was used to test for heterogeneity among trials, and the I 2 index, which expresses the proportion of variability of the results due to heterogeneity, was calculated. A random-effects model that takes into account interstudy variation was also applied. All statistical tests were two-sided. Results Nine trials that included a total of 2968 patients were analyzed; overall median follow-up was 1021 days. The objective response rate was higher for patients treated with cisplatin than for patients treated with carboplatin (30% versus 24%, respectively; OR = 1.37; 95% CI = 1.16 to 1.61; P<.001). Carboplatin treatment was associated with a non–statistically significant increase in the hazard of mortality relative to treatment with cisplatin (HR = 1.07; 95% CI = 0.99 to 1.15; P = .100). In patients with nonsquamous tumors and those treated with third-generation chemotherapy, carboplatin-based chemotherapy was associated with a statistically significant increase in mortality (HR = 1.12; 95% CI = 1.01 to 1.23 and HR = 1.11; 95% CI = 1.01 to 1.21, respectively). Cisplatin-based chemotherapy was associated with more severe nausea and vomiting and nephrotoxicity; severe thrombocytopenia was more frequent during carboplatin-based chemotherapy. Conclusions Our individual patient data meta-analysis suggests that cisplatin-based chemotherapy is slightly superior to carboplatin-based chemotherapy in terms of response rate and, in certain subgroups, in prolonging survival without being associated with an increase in severe toxic effects. Therefore, cisplatin-based third-generation regimens should remain the standard reference for the treatment of selected patients with advanced-stage NSCLC and of those with earlier-stage disease.
This research addresses ongoing rock fall processes that affect the tract of the ancient Appia route crossing the Apennines at the Aurunci Mountain pass (central Italy). Elements of cultural heritage ...are endangered as calcareous blocks descending from the rock slope that delimits the route track were observed lying on the pavement. Based on cooperation between geologists and experts in remote sensing, a multi-disciplinary study was pursued to assess rock fall susceptibility. This study included aero-photogrammetric reconstruction of slope topography, field-based structural and kinematic analyses, terrestrial laser scanner and unmanned aerial system surveys and probabilistic rock fall modelling. This last was performed by simulating a large number of 3D trajectories and initially adopting a lumped mass approach, therefore tracking dimensionless rock blocks (kinematic modelling). The structural setting of the investigated rock slope shows evidence of four tectonic phases, including in chronological order folding, thrusting, strike-slip and normal faulting. Non-homogeneous joint sets distribution within the rock masses, due to the tectonic inheritance, was found to strongly condition rock failure mechanisms and sizes of detaching blocks. Different estimates of design rock block volumes and masses were integrated into kinematic modelling, finally achieving a dynamic 3D reconstruction of the rock fall process. Based on modelling results, a remediation plan has been drafted focused on positioning and sizing of elastic barriers.
The definition of landslide hazard is a step-like procedure that encompasses the quantification of its spatial and temporal attributes, i.e., a reliable definition of landslide susceptibility and a ...detailed analysis of landslide recurrence. However, available information is often incomplete, fragmented and unsuitable for reliable quantitative analysis. Nevertheless, landslide hazard evaluation has a key role in the implementation of risk mitigation policies and an effort should be done to retrieve information and make it useful for this purpose. In this research, we go through this topic of optimising the information available in catalogues, starting from landslide inventory review and constitution of a boosted training dataset, propaedeutic for susceptibility analysis based on machine learning methods. The temporal recurrence of landslide events has been approached here either through the definitions of large-scale quantitative hazard descriptors or by analysis of historical rainfall (i.e., the main triggering factor for the considered shallow earth slope failures) databases through the definition of rainfall probability curves. Spatial and temporal attributes were integrated, selecting potential landslide source areas ranked in terms of hazard. Data integration was also pursued through persistent scatterer interferometry analysis which pointed out areas of interest within potential landslide source areas featured by ongoing ground movement. The consequential approach led to the definition of the first hazard product of the city of Rome at a local scale functional for advisory purposes or the statutory level, representing a thematic layer able to orient the risk managers and infrastructure stakeholders.
Hundreds of landslides were triggered by the mainshocks (up to Mw 6.5) that occurred in 2016 in Central Italy during the seismic sequence that originated in the Apennine and ended in January 2017. ...These landslides were studied via field-based investigation and remote sensing techniques during the weeks immediately after the mainshocks occurred. EarthQuake-triggered Landslides (EQtLs) mostly consisted of rockfalls and rockslides. The spatial distribution of the examined EQtLs with respect to the epicentres of the main shocks resulted in very good agreement with the available empirical curves of maximum distance vs. magnitude. Based on the collected dataset, approximately 70% of the landslides impacted transportation routes (national, provincial and secondary roads linking towns and mountain villages) since they principally detached from road cuts. The landslides caused traffic interruption, and some delayed rescue vehicles from reaching the zones most damaged by earthquakes; moreover, some landslides caused the temporary isolation of several localities in the epicentre area. Even if it seems obvious that road cuts favour slope failure under shaking conditions, the dataset reported here is the first one for Italy where such an effect is quantified. Moreover, a statistical analysis was conducted to explore the relationships between the spatial distribution of EQtLs and some selected causative factors, including both natural (i.e., earthquake and terrain) and anthropogenic factors (i.e., presence of roads and trackways). Among the considered combinations of causative factors (both natural and anthropogenic), this study demonstrates that the occurrence of the uphill road cuts at the bottom of deep incised V-shaped valleys strongly influenced the spatial clustering of the EQtL triggered in 2016 in Central Italy.
OBJECTIVES
The objective of this study was to assess the prognostic role of preoperative quality of life (QoL) in patients operated on for early-stage non-small-cell lung cancer (NSCLC).
METHODS
This ...is an observational analysis of 131 consecutive patients (2003-08) submitted to pulmonary lobectomy and systematic nodal dissection for pathological pT1N0 or pT2N0 stages NSCLC with a complete follow-up (median 40 months). QoL was measured by the Short Form 36v2, a multidimensional survey assessing eight domains and two composite scales (physical component score PCS and mental component score MCS). Survival was calculated by the Kaplan-Meier method. The log-rank test was used to assess differences between groups. The relationships between survival and QoL composite scales were determined by Cox proportional hazards regression analysis adjusting for the effect of several baseline and clinical variables. PCS and MCS were categorized according to their values greater or lower than 50 percentiles (general population norms).
RESULTS
Fifty-three (40%) patients had PCS <50 and 71 (54%) had MCS <50. Results from physical functioning (P = 0.03) and general health (P = 0.03) scales were directly associated with survival. Multivariable regression showed that significant factors associated with overall survival were age >70 (hazard ratio HR 2.4, 95% confidence interval 95% CI 1.2-4.8, P = 0.01) and PCS <50 (HR 2.3, 95% CI 1.4-4.4, P = 0.01). MCS, pT stage, histology, forced expiratory volume in 1 s, DLCO were not associated with prognosis. Patients with PCS >50 lived longer than those with PCS <50 (5-year overall survival 79 vs 49%, P = 0.01), in both pT1 (5-year overall survival 80 vs 49%) and pT2 stages (5-year overall survival 78 vs 48%). Cancer-specific 5-year survival was better in patients with a preoperative PCS >50 compared with those with PCS <50 (89 vs 73%, P = 0.05). Deaths due to cancer recurrence were similar in patients with PCS <50 and >50 (55 vs 53%, P = 0.9).
CONCLUSIONS
The physical component of QoL was associated with overall and cancer-specific survivals in patients operated on for early-stage NSCLC. Supportive interventions aimed at improving the perception of physical well-being should be tested to verify whether they can improve long-term prognosis after lung cancer surgery.
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