We develop statistical tools for time series analysis of large multivariate datasets, when a few core series are of principal interest and there are many potential auxiliary predictive variables. The ...methodology, based on Vector Autoregressions (VAR), handles the case where unrestricted fitting is precluded by a large number of series and a huge parameter space. In particular, we adopt a forecast error criterion and use Granger-causality tests in a sequential manner to build a VAR model that targets the main variables. This approach affects variable reduction (or equivalently, sparsity restrictions) in a computationally fast way that remains feasible for large dimensions. The search for the best model results in a VAR, fitted with a selection of supporting series, that has the best possible forecast performance with respect to the core variables. We apply the statistical methodology to model real Gross Domestic Product and the national Unemployment Rate, two time series widely monitored by economists and policy-makers, based on a large set of Quarterly Workforce Indicators comprising various major sectors of the economy and different measures of labor market conditions.
The formal syntheses of N-methylwelwitindolinone C isothiocyanate, N-methylwelwitindolinone C isonitrile, N-methylwelwitindolinone D isonitrile, 3-hydroxy-N-methylwelwitindolinone C isothiocyanate, ...and 3-hydroxy-N-methylwelwitindolinone C isonitrile are reported. The synthesis features several novel processes, including a Lewis acid mediated coupling between a benzylic-type heteroaromatic alcohol and a highly functionalized silyl ketene acetal, an intramolecular enolate arylation, and a regioselective, Pd(0)-catalyzed π-allylic cyclization of a γ-benzoyloxy enone moiety that is revealed by unmasking a furan ring.
Interleukin-1 receptor-associated kinase 4 (IRAK4) is the most upstream kinase in Toll/Interleukin-1 receptor (TIR) signaling. Human and rodent genetics support the role of IRAK4 in immune function ...and the involvement of IRAK4-dependent signaling in certain cancers is hypothesized. The accumulating evidence has motivated the discovery of IRAK4 inhibitors that could be used therapeutically. Areas covered: This review summarizes patents published in 2016-2018 claiming IRAK4 inhibitors. Representative analogues from each patent are presented with a focus on compounds that have been profiled in cellular and in vivo assays. Expert opinion: The last three years have seen an increased number of IRAK4 inhibitors with which to assess the therapeutic potential of the target. At least 5 companies are believed to have advanced to the clinic. Pfizer is in phase II for rheumatoid arthritis (RA). The outcomes of these studies should inform on the therapeutic potential in autoimmune disease and cancer.
Spectral measurements of ultraviolet-B radiation made at Toronto since 1989 indicate that the intensity of light at wavelengths near 300 nanometers has increased by 35 percent per year in winter and ...7 percent per year in summer. The wavelength dependence of these trends indicates that the increase is caused by the downward trend in total ozone that was measured at Toronto during the same period. The trend at wavelengths between 320 and 325 nanometers is essentially zero.
Factor VII deficiency diagnosed after minor genital trauma Reeves, J. A.; Dowlut‐McElroy, T.; Mou, S. M. ...
Haemophilia : the official journal of the World Federation of Hemophilia,
March 2017, 2017-03-00, 20170301, Letnik:
23, Številka:
2
Journal Article
The formal syntheses of N-methylwelwitindolinone C isothiocyanate (4) and several other welwitindolinones 5–8 were achieved by the independent synthesis of 79. The synthesis featured a Lewis ...acid-mediated coupling between a heteroaryl carbinol and bis-TMS enol ether, an intramolecular enolate arylation, and an unprecedented intramolecular allylic alkylation of a γ-acyloxyenone.
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Dobson and Brewer spectrophotometer and filter ozonometer data available from the World Ozone and Ultraviolet Data Centre (WOUDC) were compared with satellite total ozone measurements from TOMS ...(onboard Nimbus 7, Meteor 3, and Earth Probe satellites), OMI (AURA satellite) and GOME (ERS‐2 satellite) instruments. Five characteristics of the difference with satellite data were calculated for each site and instrument type: the mean difference, the standard deviation of daily differences, the standard deviation of monthly differences, the amplitude of the seasonal component of the difference, and the range of annual values. All these characteristics were calculated for five 5‐year‐long bins and for each site separately for direct sun (DS) and zenith sky (ZS) ozone measurements. The main percentiles were estimated for the five characteristics of the difference and then used to establish criteria for “suspect” or “outlier” sites for each characteristic. About 61% of Dobson, 46% of Brewer, and 28% of filter stations located between 60°S and 60°N have no “suspect” or “outlier” characteristics. In nearly 90% of all cases, Dobson and Brewer sites demonstrated 5‐year mean differences with satellites to be within ±3% (for DS observations). The seasonal median difference between all Brewer DS measurements at 25°–60°N and GOME and OMI overpasses remained within ±0.5% over a period of more than 10 years. The satellite instrument performance was also analyzed to determine typical measurement uncertainties. It is demonstrated that systematic differences between the analyzed satellite instruments are typically within ±2% and very rarely are they outside the ±3% envelope. As the satellite instrument measurements appear to be better than ±3%, ground‐based instruments with precision values worse than ±3% are not particularly useful for the analyses of long‐term changes and comparison with numerical simulations.
Spectrometers are designed to isolate particular wavebands and suppress light from wavelengths outside the band of interest. However, a small amount of undesired light will always enter the detector, ...not through the designed optical path, but through random scattering from the instrument optical components, housing, and dust particles. Every spectrophotometer has stray light coming from outside the nominal measurement waveband. For Dobson spectrophotometers and single monochromator Brewer spectrophotometers, which are basic instruments in the World Meteorological Organization (WMO) ozone and ultraviolet (UV) monitoring network, the error introduced by stray light is substantial when the ozone slant path becomes very large because of high solar zenith angles and a thick ozone layer. These are common conditions during Arctic spring. To study the issue, a long ozone slant path Intercomparison/Calibration campaign for Nordic Brewers and Dobsons was held at Sodankylä 8-24 March 2011 and a follow-up campaign to extend calibrations to shorter ozone slant paths took place at Izaña observatory, Tenerife, between 28 October and 18 November 2011. These campaigns were part of the Committee on Earth Observation Satellites (CEOS) Intercalibration of Ground-based Spectrometers and Lidars project funded by the European Space Agency (ESA), intended to permit the homogenization of ozone data from the European ozone ground-truthing network. During the active intercomparison periods, measurements were taken only when good conditions for sun or moon observations existed. Laboratory measurements using calibration lamps and helium-cadmium (HeCd) lasers were an essential part of both campaigns. The campaigns produced a high-quality database of total ozone and UV measurements and an accurate, up-to-date calibration and characterization of participating Brewers and Dobsons against the European standard instruments from the Regional Dobson Calibration Centre-Europe (RDCC-E) and the Regional Brewer Calibration Centre-Europe (RBCC-E). In the present work we focus on single monochromator Brewers and present a physics-based method to compensate for the stray-light effects in ozone retrieval using laboratory characterizations and radiative transfer modelling. The method was tested with independent data from the campaign.
Both cryptic and aposematic colour patterns can reduce predation risk to prey. These distinct strategies may not be mutually exclusive, because the impact of prey coloration depends on a predator's ...sensory system and cognition and on the environmental background. Determining whether prey signals are cryptic or aposematic is a prerequisite for understanding the ecological and evolutionary implications of predator–prey interactions. This study investigates whether coloration and pattern in an exceptionally polymorphic toad, Rhinella alata, from Barro Colorado Island, Panama reduces predation via background matching, disruptive coloration, and/or aposematic signaling. When clay model replicas of R. alata were placed on leaf litter, the model's dorsal pattern – but not its colour – affected attack rates by birds. When models were placed on white paper, patterned and un‐patterned replicas had similar attack rates by birds. These results indicate that dorsal patterns in R. alata are functionally cryptic and emphasize the potential effectiveness of disruptive coloration in a vertebrate taxon.
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