Highlights ► This review summarizes the effects of glucocorticoids and BDNF on neural plasticity. ► BDNF localization and activation of its receptors are described. ► Trophic effects of ...glucocorticoids are compared in hippocampus and amygdala. ► Interactions with neurotransmitters and other signaling molecules are covered.
In a recent paper series, the authors have promoted convex optimization algorithms for radio-interferometric imaging in the framework of compressed sensing, which leverages sparsity regularization ...priors for the associated inverse problem and defines a minimization problem for image reconstruction. This approach was shown, in theory and through simulations in a simple discrete visibility setting, to have the potential to outperform significantly clean and its evolutions. In this work, we leverage the versatility of convex optimization in solving minimization problems to both handle realistic continuous visibilities and offer a highly parallelizable structure paving the way to significant acceleration of the reconstruction and high-dimensional data scalability. The new algorithmic structure promoted relies on the simultaneous-direction method of multipliers (SDMM) and contrasts with the current major-minor cycle structure of clean and its evolutions, which in particular cannot handle the state-of-the-art minimization problems under consideration where neither the regularization term nor the data term are differentiable functions. We release a beta version of an SDMM-based imaging software written in c and dubbed purify (http://basp-group.github.io/purify/) that handles various sparsity priors, including our recent average sparsity approach sparsity averaging reweighted analysis (SARA). We evaluate the performance of different priors through simulations in the continuous visibility setting, confirming the superiority of SARA.
The weak lensing bispectrum induced by gravity Munshi, D; Namikawa, T; Kitching, T D ...
Monthly Notices of the Royal Astronomical Society,
04/2020, Letnik:
493, Številka:
3
Journal Article
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ABSTRACT
Recent studies have demonstrated that secondary non-Gaussianity induced by gravity will be detected with a high signal-to-noise ratio (S/N) by future and even by on-going weak lensing ...surveys. One way to characterize such non-Gaussianity is through the detection of a non-zero three-point correlation function of the lensing convergence field, or of its harmonic transform, the bispectrum. A recent study analysed the properties of the squeezed configuration of the bispectrum, when two wavenumbers are much larger than the third one. We extend this work by estimating the amplitude of the (reduced) bispectrum in four generic configurations, i.e. squeezed, equilateral, isosceles and folded, and for four different source redshifts zs = 0.5, 1.0, 1.5, 2.0, by using an ensemble of all-sky high-resolution simulations. We compare these results against theoretical predictions. We find that, while the theoretical expectations based on widely used fitting functions can predict the general trends of the reduced bispectra, a more accurate theoretical modelling will be required to analyse the next generation of all-sky weak lensing surveys. The disagreement is particularly pronounced in the squeezed limit.
Abstract
We report results from continued timing observations of PSR J0740+6620, a high-mass, 2.8 ms radio pulsar in orbit with a likely ultracool white dwarf companion. Our data set consists of ...combined pulse arrival-time measurements made with the 100 m Green Bank Telescope and the Canadian Hydrogen Intensity Mapping Experiment telescope. We explore the significance of timing-based phenomena arising from general relativistic dynamics and variations in pulse dispersion. When using various statistical methods, we find that combining ∼1.5 yr of additional, high-cadence timing data with previous measurements confirms and improves on previous estimates of relativistic effects within the PSR J0740+6620 system, with the pulsar mass
m
p
=
2.08
−
0.07
+
0.07
M
⊙
(68.3% credibility) determined by the relativistic Shapiro time delay. For the first time, we measure secular variation in the orbital period and argue that this effect arises from apparent acceleration due to significant transverse motion. After incorporating contributions from Galactic differential rotation and off-plane acceleration in the Galactic potential, we obtain a model-dependent distance of
d
=
1.14
−
0.15
+
0.17
kpc (68.3% credibility). This improved distance confirms the ultracool nature of the white dwarf companion determined from recent optical observations. We discuss the prospects for future observations with next-generation facilities, which will likely improve the precision on
m
p
for J0740+6620 by an order of magnitude within the next few years.
Chronic and acute stressors have been linked to changes in hippocampal function and anxiety-like behaviors. Both produce changes in gene expression, but the extent to which these changes endure ...beyond the end of stress remains poorly understood. As an essential first step to characterize abnormal patterns of gene expression after stress, this study demonstrates how chronic restraint stress (CRS) modulates gene expression in response to a novel stressor in the hippocampus of wild-type mice and the extent to which these changes last beyond the end of CRS. Male C57/bl6 mice were subjected to (1) a forced swim test (FST), (2) corticosterone (Cort) or vehicle injections, (3) CRS for 21 days and then a FST, or (4) allowed to recover 21 days after CRS and subjected to FST. Hippocampal mRNA was extracted and used to generate cDNA libraries for microarray hybridization. Naive acute stressors (FST and vehicle injection) altered similar sets of genes, but Cort treatment produced a profile that was distinct from both FST and vehicle. Exposure to a novel stress after CRS activated substantially more and different genes than naive exposure. Most genes increased by CRS were decreased after recovery but many remained altered and did not return to baseline. Pathway analysis identified significant clusters of differentially expressed genes across conditions, most notably the nuclear factor kappa-light-chain-enhancer of B cells (NF-κB) pathway. Quantitative reverse transcription-PCR (qRT-PCR) validated changes from the microarrays in known stress-induced genes and confirmed alterations in the NF-κB pathway genes, Nfkbia, RelA and Nfkb1. FST increased anxiety-like behavior in both the naive and recovery from CRS conditions, but not in mice 24h subsequent to their CRS exposure. These findings suggest that the effects of naive stress are distinct from Cort elevation, and that a history of stress exposure can permanently alter gene expression patterns in the hippocampus and the behavioral response to a novel stressor. These findings establish a baseline profile of normal recovery and adaptation to stress. Importantly, they will serve as a conceptual basis to facilitate the future study of the cellular and regional basis of gene expression changes that lead to impaired recovery from stress, such as those that occur in mood and anxiety disorders.
ABSTRACT
We compute the low-ℓ limit of the family of higher order spectra for projected (2D) weak lensing convergence maps. In this limit these spectra are computed to an arbitrary order using ...tree-level perturbative calculations. We use the flat-sky approximation and Eulerian perturbative results based on a generating function approach. We test these results for the lower order members of this family, i.e. the skew- and kurt-spectra against state-of-the-art simulated all-sky weak lensing convergence maps and find our results to be in very good agreement. We also show how these spectra can be computed in the presence of a realistic sky-mask and Gaussian noise. We generalize these results to 3D and compute the equal-time higher order spectra. These results will be valuable in analysing higher order statistics from future all-sky weak lensing surveys such as the Euclid survey at low-ℓ modes. As illustrative examples, we compute these statistics in the context of the Horndeski and beyond Horndeski theories of modified gravity. They will be especially useful in constraining theories such as the Gleyzes–Langlois–Piazza–Vernizzi (GLPV) theories and degenerate higher order scalar-tensor theories as well as the commonly used normal-branch of Dvali–Gabadadze–Porrati model, clustering quintessence models and scenarios with massive neutrinos.
Alzheimer's disease (AD) and age-related cognitive decline represent a growing health burden and involve the hippocampus, a vulnerable brain region implicated in learning and memory. To understand ...the molecular effects of aging on the hippocampus, this study characterized the gene expression changes associated with aging in rodents using RNA-sequencing (RNA-seq). The glutamate modulator, riluzole, which was recently shown to improve memory performance in aged rats, prevented many of the hippocampal age-related gene expression changes. A comparison of the effects of riluzole in rats against human AD data sets revealed that many of the gene changes in AD are reversed by riluzole. Expression changes identified by RNA-Seq were validated by qRT-PCR open arrays. Riluzole is known to increase the glutamate transporter EAAT2's ability to scavenge excess glutamate, regulating synaptic transmission. RNA-seq and immunohistochemistry confirmed an increase in EAAT2 expression in hippocampus, identifying a possible mechanism underlying the improved memory function after riluzole treatment.
ABSTRACT
We propose a novel algorithm for image reconstruction in radio interferometry. The ill‐posed inverse problem associated with the incomplete Fourier sampling identified by the visibility ...measurements is regularized by the assumption of average signal sparsity over representations in multiple wavelet bases. The algorithm, defined in the versatile framework of convex optimization, is dubbed Sparsity Averaging Reweighted Analysis. We show through simulations that the proposed approach outperforms state‐of‐the‐art imaging methods in the field, which are based on the assumption of signal sparsity in a single basis only.
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