Summary
We prospectively observed 36 haematological patients with mucormycosis from nine hospitals of St. Petersburg during 2004–2013. The most frequent underlying diseases were acute leukaemia ...(64%), and main risk factors were prolonged neutropenia (92%) and lymphocytopenia (86%). In 50% of the patients, mucormycosis was diagnosed 1–65 days after invasive aspergillosis. Main clinical form of mucormycosis was pulmonary (64%), while two or more organ involvement was noted in 50% of the cases. The most frequent aetiological agents of mucormycosis were Rhizopus spp. (48%). Twelve‐week survival rate was 50%. Combination therapy (echinocandins + amphotericin B forms) and recovery from the underlying disease significantly improved the survival rate.
El documento discute los problemas asociados con el desarrollo de la competencia creativa de los estudiantes a través de la actividad de concierto y actuación. Se ha examinado la literatura ...científica, que abarca las nociones de creatividad (desde la perspectiva de la ciencia filosófica), la actividad creativa, la competencia creativa (desde la ciencia pedagógica) y la creatividad (desde el campo de la psicología). Se han analizado los problemas de organizar y ofrecer presentaciones de conciertos para estudiantes. Se describe el proceso de organizar los preparativos para diversos eventos creativos en los que los estudiantes toman parte activa para desarrollar su competencia creativa.
Despite extensive research in the field of thrombotic diseases, the prevention of blood clots remains an important area of study. Therefore, the development of new anticoagulant drugs with better ...therapeutic profiles and fewer side effects to combat thrombus formation is still needed. Herein, we report the synthesis and evaluation of novel pyrroloquinolinedione-based rhodanine derivatives, which were chosen from 24 developed derivatives by docking as potential molecules to inhibit the clotting factors Xa and XIa. For the synthesis of new hybrid derivatives of pyrrolo3,2,1-
quinoline-2-one, we used a convenient structural modification of the tetrahydroquinoline fragment by varying the substituents in positions 2, 4, and 6. In addition, the design of target molecules was achieved by alkylating the amino group of the rhodanine fragment with propargyl bromide or by replacing the rhodanine fragment with 2-thioxoimidazolidin-4-one. The in vitro testing showed that eight derivatives are capable of inhibiting both coagulation factors, two compounds are selective inhibitors of factor Xa, and two compounds are selective inhibitors of factor XIa. Overall, these data indicate the potential anticoagulant activity of these molecules through the inhibition of the coagulation factors Xa and XIa.
Sodium polyanionic compounds with transition metals are of considerable research interest for the search of new cathode materials for sodium‐ion batteries. In this work, we employed ab initio ...calculations to evaluate three key battery properties: phase stability, diffusion barriers and redox voltage of low‐symmetry molybdates NaMFe(MoO4)3 (M = Mg, Ni) with α‐ and β‐NaFe2(MoO4)3 structures. First, we showed that the Hubbard Ucorrection within the GGA + Uapproach is necessary to correctly refer these molybdates to semiconductors. The sodium diffusion along various pathways was thoroughly examined, which allowed us to establish the most probable pathways with the lowest migration barriers. These compounds have different directions of sodium diffusion with twice different barriers that was associated to the peculiarities of their crystal structure. The high potentials and structural stability during sodium extraction, along with low‐diffusion barriers predicted for NaMFe(MoO4)3 (M = Mg, Ni) indicate that these molybdates may be promising high‐voltage cathode materials for sodium‐ion batteries.
We provide an ab initio insight into the electronic structure, diffusion mechanism and redox process in low‐symmetry molybdates NaMFe(MoO4)3 (M = Mg, Ni). New diffusion pathways were examined in the structure that allowed us to revise the experimental data for these materials. The predicted low‐diffusion barriers and high voltages indicate that these molybdates, like NASICON‐type compounds, can be promising materials for Na‐ion batteries.
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