This study deals with the redevelopment of buildings built in the last decades of the Nineteenth century, with a style that can be defined "post-modern". In those years, communication became an ...architectural theme superimposed and abstract by functional and structural needs, with "architectural elements" abstract in a hyperbolic way with respect to the function. The result of an architectural culture, interesting for the research they narrate but incongruous with functional needs, also because of the materials used, the energy and architectural requirements impose a review to combine functional performance, in nZEB projection, and structural with the need for "venustas", what is "done well", the same facet of the same architectural rationale. The need to renew these spaces must take into account the qualities of forms that, with their material decay and in the peculiar language, may not bring out the centrality of preserving and compositional choices of the work.
The research aims to preserve and support the historical memory of Perugia's Fontivegge district through an analysis and valorisation of the existing cultural heritage. The selected case study is ...represented by the original design of the station, ideated by architect Antonio Cipolla. In order to enhance this project, which was never realised, it was decided to exploit the three-dimensional reconstruction of the building, which had already been elaborated previously, to create a virtual reality experience, through users can visualize, explore and walk inside the build. The purpose is to consolidate the relationship between the historical memory of the city and its users, allowing them a new interaction with the space and bringing them to a deeper level of knowledge and understanding of the place they live. To increase the user base of this virtual experience, it was decided to create an application for mobile devices. The Unreal Engine software was selected for development, given the ease of exporting projects for the main mobile platforms (Android, iOS) and the specific functions for reading GPS data. In fact, the application only allows the exploration of the virtual scenario to real users of the place, so they physically visit it and thus can understand the differences and similarities between the real scenario and the virtual historical reconstruction. Once the geolocation is verified, the app provides the 3D model for a panoramic view of the build under examination and, subsequently, an immersive experience in which it is possible to freely navigate within the virtual reconstruction.
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neurodegenerative disease due to mutations in
SACS,
which encodes sacsin, a protein localized on the mitochondrial surface and ...possibly involved in mitochondrial dynamics. In view of the possible mitochondrial involvement of sacsin, we investigated mitochondrial activity at functional and molecular level in skin fibroblasts obtained from ARSACS patients. We observed remarkable bioenergetic damage in ARSACS cells, as indicated by reduced basal, adenosine triphosphate (ATP)-linked and maximal mitochondrial respiration rate, and by reduced respiratory chain activities and mitochondrial ATP synthesis. These phenomena were associated with increased reactive oxygen species production and oxidative nuclear DNA damage. Our results suggest that loss of sacsin is associated with oxidative stress and mitochondrial dysfunction, and thus highlight a novel mechanism in the pathogenesis of ARSACS. The involvement of mitochondria and oxidative stress in disease pathogenesis has been described in a number of other neurodegenerative diseases. Therefore, on the basis of our findings, which suggest a potential therapeutic role for antioxidant agents, ARSACS seems to fall within a larger group of disorders.
In view of the LHC upgrade for the High Luminosity phase (HL-LHC), the ATLAS experiment plans to replace the Inner Detector with an all-silicon system. The n-on-p silicon technology is a promising ...candidate to achieve a large area instrumented with pixel sensors, since it is radiation hard and cost effective. The paper reports on the performance of thin 100 and 130μm n-in-p planar pixel sensors produced by FBK-CMM with active-edge technology in collaboration with LPNHE and INFN. Beam-test results are presented, with focus on the hit efficiency at the detector edge of a novel design consisting of a staggered deep trench.
Development of a new generation of 3D pixel sensors for HL-LHC Dalla Betta, G.-F.; Boscardin, M.; Darbo, G. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
07/2016, Letnik:
824
Journal Article
Recenzirano
Odprti dostop
This paper covers the main technological and design aspects relevant to the development of a new generation of thin 3D pixel sensors with small pixel size aimed at the High-Luminosity LHC upgrades.
Results of an extensive R&D program aiming at radiation hard, small pitch, 3D pixel sensors are reported. The CMS experiment is supporting this R&D in the scope of the Inner Tracker upgrade for the ...High Luminosity phase of the CERN Large Hadron Collider (HL-LHC). In the HL-LHC the Inner Tracker will have to withstand an integrated fluence up to 2.3×1016neq/cm2. A small number of 3D sensors were interconnected with the RD53A readout chip, which is the first prototype of 65 nm CMOS pixel readout chip designed for the HL-LHC pixel trackers. In this paper results obtained in beam tests before and after irradiation are reported. The irradiation of a single chip module was performed up to a maximum equivalent fluence of about 1×1016neq/cm2. The analysis of the collected data shows excellent performance: the spatial resolution in not irradiated sensors can reach about 3 to 5 μm, for inclined tracks, depending on the pixel pitch. The measured hit detection efficiencies are close to 99% measured both before and after the above mentioned irradiation fluence.
Determination of mitochondrial DNA (mtDNA) heteroplasmy for the diagnosis of patients with mitochondrial disorders is a difficult task due to the coexistence of wild-type and mutant genomes. We have ...developed a new method for genotyping and quantification of heteroplasmic point mutations in mtDNA based on the SNaPshot technology. We compared the data of this method with the widely used “last hot-cycle” PCR-RFLP method by studying 15 patients carrying mtDNA mutations. We showed that SNaPshot is an accurate, reproducible, and sensitive technique for the determination of heteroplasmic mtDNA mutations in different tissues from patients, and it is a promising system to be used in prenatal and postnatal diagnosis of mtDNA-associated disorders.
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