Using a BESIII-data sample of 1.31 × 109 J/ψ events collected in 2009 and 2012, the glueball-sensitive decay J/ψ→γpp¯ is analyzed. In the past, an exciting near-threshold enhancement X (pp¯) showed ...up. Furthermore, the poorly-understood properties of the ηc resonance, its radiative production, and many other interesting dynamics can be studied via this decay. The high statistics provided by BESIII enables to perform a partial-wave analysis (PWA) of the reaction channel. With a PWA, the spin-parity of the possible intermediate glueball state can be determined unambiguously and more information can be gained about the dynamics of other resonances, such as the ηc. The main background contributions are from final-state radiation and from the J/ψ→π0(γγ)pp¯ channel. In a follow-up study, we will investigate the possibilities to further suppress the background and to use data-driven methods to control them.
Kidney transplant recipients (KTRs) elicit an impaired immune response after COVID-19 vaccination; however, the exact clinical impact remains unclear. We therefore analyse the relationship between ...antibody levels after vaccination and the risk of COVID-19 in a large cohort of KTRs. All KTRs living in the Netherlands were invited to send a blood sample 28 days after their second COVID-19 vaccination for measurement of their IgG antibodies against the receptor-binding domain of the SARS-CoV-2 spike protein (anti-RBD IgG). Information on COVID-19 was collected from the moment the blood sample was obtained until 6 months thereafter. Multivariable Cox and logistic regression analyses were performed to analyse which factors affected the occurrence and severity (i.e., hospitalization and/or death) of COVID-19. In total, 12,159 KTRs were approached, of whom 2885 were included in the analyses. Among those, 1578 (54.7%) became seropositive (i.e., anti-RBD IgG level >50 BAU/mL). Seropositivity was associated with a lower risk for COVID-19, also after adjusting for multiple confounders, including socio-economic status and adherence to COVID-19 restrictions (HR 0.37 (0.19-0.47),
= 0.005). When studied on a continuous scale, we observed a log-linear relationship between antibody level and the risk for COVID-19 (HR 0.52 (0.31-0.89),
= 0.02). Similar results were found for COVID-19 severity. In conclusion, antibody level after COVID-19 vaccination is associated in a log-linear manner with the occurrence and severity of COVID-19 in KTRs. This implies that if future vaccinations are indicated, the aim should be to reach for as high an antibody level as possible and not only seropositivity to protect this vulnerable patient group from disease.
•COVID-19 associated with long-lasting symptoms in patients with advanced kidney disease.•Post COVID-19 condition (PCC) occurs in 24% of patients with advanced kidney disease.•Less likelihood of PCC ...if higher SARS-CoV-2 vaccine induced antibody levels.•More likelihood of PCC if previously hospital admitted during COVID-19.
The burden of post COVID-19 condition (PCC) is not well studied in patients with advanced kidney disease.
A large prospective cohort of SARS-CoV-2 vaccinated patients with chronic kidney disease stages G4–G5 (CKD G4/5), on dialysis, and kidney transplant recipients (KTR) were included. Antibody levels were determined after vaccination. Presence of long-lasting symptoms was assessed in patients with and without prior COVID-19 and compared using logistic regression. In patients with prior COVID-19, PCC was defined according to the WHO definition.
Two hundred sixteen CKD G4/5 patients, 375 dialysis patients, and 2005 KTR were included. Long-lasting symptoms were reported in 204/853 (24%) patients with prior COVID-19 and in 297/1743 (17%) patients without prior COVID-19 (aOR: 1.45 (1.17–1.78), P < 0.001). PCC was prevalent in 29% of CKD G4/5 patients, 21% of dialysis patients, and 24% of KTR. In addition, 69% of patients with PCC reported (very) high symptom burden. Odds of PCC was lower per 10-fold increase in antibody level after vaccination (aOR 0.82 0.70–0.96, P = 0.01) and higher in case of COVID-19 related hospital admission (aOR 4.64 2.61–8.25, P = 0.003).
CKD G4/5 patients, dialysis patients, and KTR are at risk for PCC with high symptom burden after SARS-CoV-2 vaccination, especially if antibody levels are low and in case of hospitalization due to COVID-19.
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The Nπ^{0}π^{0} decays of positive-parity N^{*} and Δ^{*} resonances at about 2 GeV are studied at ELSA by photoproduction of two neutral pions off protons. The data reveal clear evidence for several ...intermediate resonances: Δ(1232), N(1520)3/2^{-}, and N(1680)5/2^{+}, with spin parities J^{P}=3/2^{+}, 3/2^{-}, and 5/2^{+}. The partial wave analysis (within the Bonn-Gatchina approach) identifies N(1440)1/2^{+} and the N(ππ)_{S wave} (abbreviated as Nσ here) as further isobars and assigns the final states to the formation of nucleon and Δ resonances and to nonresonant contributions. We observe the known Δ(1232)π decays of Δ(1910)1/2^{+}, Δ(1920)3/2^{+}, Δ(1905)5/2^{+}, Δ(1950)7/2^{+}, and of the corresponding spin-parity series in the nucleon sector, N(1880)1/2^{+}, N(1900)3/2^{+}, N(2000)5/2^{+}, and N(1990)7/2^{+}. For the nucleon resonances, these decay modes are reported here for the first time. Further new decay modes proceed via N(1440)1/2^{+}π, N(1520)3/2^{-}π, N(1680)5/2^{+}π, and Nσ. The latter decay modes are observed in the decay of N^{*} resonances and at most weakly in Δ^{*} decays. It is argued that these decay modes provide evidence for a 3-quark nature of N^{*} resonances rather than a quark-diquark structure.
Precision data are presented for the break-up reaction, H2(p→,pp)n, within the framework of nuclear-force studies. The experiment was carried out at KVI using a polarized-proton beam of 190 MeV ...impinging on a liquid-deuterium target and by exploiting the detector, BINA. Some of the vector-analyzing powers are presented and compared with state-of-the-art Faddeev calculations including three-nucleon forces effect. Significant discrepancies between the data and theoretical predictions were observed for kinematical configurations which correspond to the H2(p→,He2)n channel. These results are compared to the H2(p→,d)p reaction to test the isospin sensitivity of the present three-nucleon force models. The current modeling of two and three-nucleon forces is not sufficient to describe consistently polarization data for both isospin states.
The photoproduction of omega mesons on nuclei has been investigated using the Crystal Barrel/TAPS experiment at the ELSA tagged photon facility in Bonn. The aim is to study possible in-medium ...modifications of the omega meson via the reaction gamma + A --> omega + X --> pi(0)gamma + X('). Results obtained for Nb are compared to a reference measurement on a LH2 target. While for recoiling, long-lived mesons (pi(0), eta, and eta;(')), which decay outside of the nucleus, a difference in the line shape for the two data samples is not observed, we find a significant enhancement towards lower masses for omega mesons produced on the Nb target. For momenta less than 500 MeV/c an in-medium omega meson mass of M(medium) = 722(+4)(-4)(stat)+35-5(syst) MeV/c(2) has been deduced at an estimated average nuclear density of 0.6rho(0).
The immune response to COVID-19 vaccination is inferior in kidney transplant recipients (KTRs) and to a lesser extent in patients on dialysis or with chronic kidney disease (CKD). We assessed the ...immune response 6 months after mRNA-1273 vaccination in kidney patients and compared this to controls.
A total of 152 participants with CKD stages G4/5 (eGFR <30 mL/min/1.73 m2), 145 participants on dialysis, 267 KTRs, and 181 controls were included. SARS-CoV-2 Spike S1 specific IgG antibodies were measured using fluorescent bead-based multiplex-immunoassay, neutralizing antibodies to ancestral, Delta, and Omicron (BA.1) variants by plaque reduction, and T-cell responses by interferon-γ release assay.
At 6 months after vaccination, S1-specific antibodies were detected in 100% of controls, 98.7% of CKD G4/5 patients, 95.1% of dialysis patients, and 56.6% of KTRs. These figures were comparable to the response rates at 28 days, but antibody levels waned significantly. Neutralization of the ancestral and Delta variants was detected in most participants, whereas neutralization of Omicron was mostly absent. S-specific T-cell responses were detected at 6 months in 75.0% of controls, 69.4% of CKD G4/5 patients, 52.6% of dialysis patients, and 12.9% of KTRs. T-cell responses at 6 months were significantly lower than responses at 28 days.
Although seropositivity rates at 6 months were comparable to rates at 28 days after vaccination, significantly decreased antibody levels and T-cell responses were observed. The combination of low antibody levels, reduced T-cell responses, and absent neutralization of the newly emerging variants indicates the need for additional boosts or alternative vaccination strategies in KTRs.
NCT04741386.
.
Precision measurements of vector and tensor analyzing powers of the
2
H(
d
,
dp
)
n
break-up process for configurations in the vicinity of the quasi-free scattering regime with the neutron as ...spectator are presented. These measurements are performed with a polarized deuteron-beam with an energy of 65MeV/nucleon impinging on a liquid-deuterium target. The experiment was conducted at the AGOR facility at KVI using the BINA 4
π
-detection system. Events for which the final-state deuteron and proton are coplanar have been analyzed and the data have been sorted for various momenta of the missing neutron. In the limit of vanishing neutron momentum and at large deuteron-proton momentum transfer, the data agree well with the measured and theoretically predicted spin observables of the elastic deuteron-proton scattering process. The agreement deteriorates rapidly with increasing neutron momentum and/or decreasing momentum transfer from the deuteron beam to the outgoing proton. This study reveals the presence of a significant contribution of final-state interactions even at very small neutron momenta.
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