Improving the anti-carbon deposition and anti-sintering ability under the premise of maintaining high catalytic activity is the core issue of Ni-based catalysts applied in CO methanation reactions. ...To address this issue, a La0.75A0.25NiO3/SiO2 (A = Ce, Sr, Sm, and Ca) catalyst is prepared via a citric acid complexation method. XRD results show that the substituted elements (Sr, Sm, and Ca) enter the LaNiO3 lattice and partially replace the A-site element La. The reduced Ni0 is beneficial to improve the medium temperature activity of the catalyst. The substitution of different elements produces different electronic effects that significantly affect the size of the Ni particles and the interaction between Ni and La2O3. The catalyst with doped Ca2+ as the A-site substituted element demonstrates better adsorption, storage, and migration capabilities for oxygen due to the lattice distortion that easily produces oxygen vacancies. Catalysts doped with Sr, Sm, and Ca as the A-site substituted element produce La2O2CO3 after the reactions, which plays a role in eliminating carbon deposits.
Improving the anti-carbon deposition and anti-sintering ability under the premise of maintaining high catalytic activity is the core issue of Ni-based catalysts applied in CO methanation reactions. ...To address this issue, a La
0.75
A
0.25
NiO
3
/SiO
2
(A = Ce, Sr, Sm, and Ca) catalyst is prepared via a citric acid complexation method. XRD results show that the substituted elements (Sr, Sm, and Ca) enter the LaNiO
3
lattice and partially replace the A-site element La. The reduced Ni
0
is beneficial to improve the medium temperature activity of the catalyst. The substitution of different elements produces different electronic effects that significantly affect the size of the Ni particles and the interaction between Ni and La
2
O
3
. The catalyst with doped Ca
2+
as the A-site substituted element demonstrates better adsorption, storage, and migration capabilities for oxygen due to the lattice distortion that easily produces oxygen vacancies. Catalysts doped with Sr, Sm, and Ca as the A-site substituted element produce La
2
O
2
CO
3
after the reactions, which plays a role in eliminating carbon deposits.
Bone defect repairs are based on bone graft fusion or replacement. Current large bone defect treatments are inadequate and lack of reliable technology. Therefore, we aimed to investigate a simple ...technique using three-dimensional (3D)-printed individualized porous implants without any bone grafts, osteoinductive agents, or surface biofunctionalization to treat large bone defects, and systematically study its long-term therapeutic effects and osseointegration characteristics. Twenty-six patients with large bone defects caused by tumor, infection, or trauma received treatment with individualized porous implants; among them, three typical cases underwent a detailed study. Additionally, a large segmental femur defect sheep model was used to study the osseointegration characteristics. Immediate and long-term biomechanical stability was achieved, and the animal study revealed that the bone grew into the pores with gradual remodeling, resulting in a long-term mechanically stable implant-bone complex. Advantages of 3D-printed microporous implants for the repair of bone defects included 1) that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility, and 2) that osseointegration between the host bone and implants was achieved without bone grafting. Our osseointegration method, in which the “implant-bone” interface fusion concept was used instead of “bone-bone” fusion, subverts the traditional idea of osseointegration.
Display omitted
•A new “implant-bone” interface fusion concept for large bone defect treatment was realized using 3D-printed porous implants.•Osseointegration was achieved without bone grafting.•An animal study revealed that the bone grew into the pores with gradual remodeling.•Immediate and long-term biomechanical stability was achieved by this method.
We reported here a reversible fluorescent chemosensor CPO for sequential recognition of Cu2+ and S2− in aqueous and biological media. This sensor CPO showed highly selective binding towards Cu2+ ...along with a fluorescence quenching due to the formation of the corresponding complex (CPO)2–Cu2+. And this phenomenon could be reversed in the presence of S2−, resulting in the recovery of its initial intense fluorescence. Moreover, sensor CPO showed a highly sensitive and selective response towards Cu2+ and S2− over other metal ions and anions. Particularly, the fluorescence “ON-OFF-ON” responding circle could be repeated over 5 times by the sequential addition of Cu2+ and S2−. More important, the actual usage of sensor CPO in the cell imaging study was further demonstrated by confocal fluorescence imaging with living cells. The cellular toxicity and quantification studies in single intact cell were also exploited by the flow cytometry analysis.
We present here a reversible fluorescent chemosensor CPO for sequential recognition of Cu2+ and S2− in aqueous and biological media. Its potential utility in living HeLa cells by using fluorescence confocal microscopy was investigated. The cellular toxicity studies indicated that our sensor CPO showed low toxicity. Display omitted
•A reversible chemosensor CPO was constructed for sequential recognition of Cu2+ and S2−.•The fluorescence confocal imaging was investigated with living HeLa cells.•The low cytotoxicity of sensor CPO was demonstrated by flow cytometry analysis.
Activations of Akt or ERK pathway induced by clinical drugs promote therapeutic failure due to decrease of drug response, and no available strategies have been developed to solve these problems. In ...this study, we found that pirarubicin (THP), one important chemotherapeutic drug for treating bladder cancer intravesically, dramatically elevated phosphorylations of both Akt and Erk1/2 in addition to inducing DNA damage. MK2206 or AZD6244, representative Akt and Erk1/2 inhibitors, respectively, profoundly sensitized bladder cancer cells to THP treatment. Interestingly, we found that inhibition of a single arm of either Akt or Erk1/2 pathway would induce the increase of another arm, indicating the existence of the crosstalk between these two pathways. Thus, simultaneous suppression of both signals may be needed for increasing the sensitivity of THP. On the other hand, we revealed that phenformin efficiently inhibited both Akt and Erk1/2 phosphorylation in a dose-dependent manner. Furthermore, we demonstrated that phenformin, mimicking dual inhibitors, plays dramatically synergistic action with THP both in vitro and in vivo. Our findings suggest that combination therapy of THP with dual inhibitors may constitute a successful strategy for improving chemotherapy response.
The Taishan Antineutrino Observatory (JUNO-TAO, or TAO) is a satellite detector for the Jiangmen Underground Neutrino Observatory (JUNO). Located near the Taishan reactor, TAO independently measures ...the reactor's antineutrino energy spectrum with unprecedented energy resolution. To achieve this goal, energy response must be well calibrated. Using the Automated Calibration Unit (ACU) and the Cable Loop System (CLS) of TAO, multiple radioactive sources are deployed to various positions in the detector to perform a precise calibration of energy response. The non-linear energy response can be controlled within 0.6% with different energy points of these radioactive sources. It can be further improved by using \(^{12}\rm B\) decay signals produced by cosmic muons. Through the energy non-uniformity calibration, residual non-uniformity is less than 0.2%. The energy resolution degradation and energy bias caused by the residual non-uniformity can be controlled within 0.05% and 0.3%, respectively. In addition, the stability of other detector parameters, such as the gain of each silicon photo-multiplier, can be monitored with a special ultraviolet LED calibration system.
PDF
