Nanostructured La
2
Ce
2
O
7
-doped YSZ coatings were developed using atmospheric plasma-spraying technique by optimizing various process parameters. To ensure the retention of nanostructure, the ...molten state of nanoagglomerates was monitored using plasma and particle diagnostic tools. It was observed that the morphology of the coating exhibits a bimodal microstructure consisting of nanozones reinforced in a matrix of fully-molten particles. The thermal diffusivity of nano-LaCeYSZ coatings is lower than that of nano and bulk YSZ. The reason for this change in thermal diffusivity may be attributed to scattering of phonons at grain boundaries, point defect scattering and higher inter-splat porosity. Also, the thermal conductivity of the nanocomposite coatings was lower than those of nanostructured and bulk YSZ coatings. XRD results show cubic zirconia with a small amount of tetragonal zirconia. The average grain size of the as-sprayed La
2
Ce
2
O
7
-YSZ nanocomposite coatings is ~150-200 nm. The improved thermal behavior is mainly due to a dense, packed, and more compact structure of the coatings.
The inhibition of seedling growth and nitrate reductase activity in 5 d old
Vigna radiata (L.) Wilczek cv. Pusa Baisakhi in the presence of 1.0 mM lead acetate increased drastically, if NaCl (6 and ...12 EC) was also present in the nutrient media along with the metal salt. Correspondingly higher endogenous Na
+ levels were accumulated in the roots and leaves of seedlings in presence of the two stresses. On the other hand, the levels of endogenous lead get reduced in presence of NaCl in both the roots and leaves. Roots accumulated more Pb
2+ and Na
+ than the leaves. The two stresses affect more drastically in the additive or even synergistic manner during the early growth phase of the seedlings.
Abstract
Myeloproliferative neoplasms (MPNs) are clonal disorders, derived from abnormal hematopoietic stem cells and result in an excessive production of blood cells. This MPN group of conditions ...encompasses different diseases with overlapping clinical and biologic similarities. The majority of the conventional therapies of MPN are palliative in nature. However, with the discovery of Janus Kinase 2 (JAK2) mutation and development of targeted JAK1/2 inhibition therapy, the therapeutic options in treatment landscape have changed dramatically. This article presents the revised Indian MPNs Working Group consensus recommendations. It highlights and brings into attention about the recent findings that have defined the state of the art of the diagnosis and therapy in the MPN area, including identification of the new driver and prognostic mutations, treatment goals in the management of myelofibrosis and polycythemia vera (PV), role of the recently approved, targeted tyrosine kinase inhibitor ruxolitinib in PV, and special issues such MPN consideration in patients with splenic vein thrombosis and the management of the disease in pregnancy.
Metal:SiO2 (metal: Ni, Ag, Au) nanocomposite films of different compositions have been prepared by atom beam co-sputtering. The estimation of composition of films is done theoretically using ...sputtering yield and relative area of metal and SiO2. The sputtering yields used for estimation of composition are calculated by three theoretical methods: Monte Carlo simulations (SRIM code), Sigmund’s theory and Sigmund’s theory modified by Anderson and Bay. Rutherford backscattering spectrometry (RBS) is also used to analyze the composition of the nanocomposite films. RUMP simulations of RBS data are performed. The errors in theoretical calculations and RBS results are estimated. It is found that SRIM is more appropriate for Ni:SiO2 nanocomposite films, while modified Sigmund’s theory based method is better for Ag:SiO2 and Au:SiO2 nanocomposite films. The possible sources of errors in theoretical methods with respect to experimental (RBS) results are also discussed.
...looking for and exclusion of IJV thrombosis before neck vein cannulation is very important for safety of the patients. ...we recommend that blind IJV cannulation should be avoided in these ...patients, and an ultrasound Doppler screening may be made before attempting IJV cannulation.
We evaluated the cross-sectional associations of N-terminal pro-B-type natriuretic peptide (NT-proBNP) with cardiac structural and functional abnormalities in a cohort of patients with chronic kidney ...disease without clinical heart failure, the Chronic Renal Insufficiency Cohort (n = 3,232). The associations of NT-proBNP with echocardiographically determined left ventricular (LV) mass and LV systolic and diastolic function were evaluated using multivariate logistic and linear regression models. Reclassification of participants' predicted risk of LV hypertrophy (LVH), systolic and diastolic dysfunction was performed using a category-free net reclassification improvement index that compared a clinical model with and without NT-proBNP. The median NT-proBNP was 126.6 pg/ml (interquartile range 55.5 to 303.7). The greatest quartile of NT-proBNP was associated with a nearly threefold odds of LVH (odds ratio 2.7, 95% confidence interval CI 1.8 to 4.0) and LV systolic dysfunction (odds ratio 2.7, 95% CI 1.7 to 4.5) and a twofold odds of diastolic dysfunction (odds ratio 2.0, 95% CI 1.3 to 2.9) in the fully adjusted models. When evaluated alone as a screening test, NT-proBNP functioned modestly for the detection of LVH (area under the curve 0.66) and LV systolic dysfunction (area under the curve 0.62) and poorly for the detection of diastolic dysfunction (area under the curve 0.51). However, when added to the clinical model, NT-proBNP significantly reclassified participants' likelihood of having LVH (net reclassification improvement 0.14, 95% CI 0.13–0.15; p <0.001) and LV systolic dysfunction (net reclassification improvement 0.28, 95% CI 0.27 to 0.30; p <0.001) but not diastolic dysfunction (net reclassification improvement 0.10, 95% CI 0.10 to 0.11; p = 0.07). In conclusion, in this large chronic kidney disease cohort without heart failure, NT-proBNP had strong associations with prevalent LVH and LV systolic dysfunction.
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