Genetic deficiencies in transcription factors can lead to the loss of certain types of cells and tissue. The steroidogenic tissue-specific nuclear receptor Ad4BP/SF-1 (NR5A1) is one such gene, ...because mice in which this gene is disrupted fail to develop the adrenal gland and gonads. However, the specific role of Ad4BP/SF-1 in these biological events remains unclear. Here we use chromatin immunoprecipitation sequencing to show that nearly all genes in the glycolytic pathway are regulated by Ad4BP/SF-1. Suppression of Ad4BP/SF-1 by small interfering RNA reduces production of the energy carriers ATP and nicotinamide adenine dinucleotide phosphate, as well as lowers expression of genes involved in glucose metabolism. Together, these observations may explain tissue dysgenesis as a result of Ad4BP/SF-1 gene disruption in vivo. Considering the function of estrogen-related receptor α, the present study raises the possibility that certain types of nuclear receptors regulate sets of genes involved in metabolic pathways to generate energy carriers.
This work reports the first observation of azimuthal asymmetries around the thrust axis in e+e− annihilation of pairs of back-to-back charged pions in one hemisphere, and π0 and η mesons in the ...opposite hemisphere. These results are complemented by a new analysis of pairs of back-to-back charged pions. The π0 and η asymmetries rise with the relative momentum z of the detected hadrons as well as with the transverse momentum with respect to the thrust axis. These asymmetries are sensitive to the Collins fragmentation function H1⊥ and provide complementary information to previous measurements with charged pions and kaons in the final state. In particular, the η final states will provide additional information on the flavor structure of H1⊥. This is the first measurement of the explicit transverse-momentum dependence of the Collins fragmentation function from Belle data. It uses a dataset of 980.4 fb−1 collected by the Belle experiment at or near a center-of-mass energy of 10.58 GeV.
The electromagnetic calorimeter (ECL) is one of the primary subsystems of the Belle II detector, used to measure the direction and momentum of photons in a wide energy range. The ECL and its data ...acquisition system include 8736 CsI(Tl) counters and 628 highly configurable modules for data readout. Several features both in the firmware and in the software were implemented to ensure efficient operation during data taking. This paper describes the development of ECL firmware, corresponding configuration, initialization and monitoring software, along with the development of ECL run control.
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