This article reports world averages of measurements of
b
-hadron,
c
-hadron, and
τ
-lepton properties obtained by the Heavy Flavor Averaging Group using results available through summer 2016. For the ...averaging, common input parameters used in the various analyses are adjusted (rescaled) to common values, and known correlations are taken into account. The averages include branching fractions, lifetimes, neutral meson mixing parameters,
C
P
violation parameters, parameters of semileptonic decays, and Cabbibo–Kobayashi–Maskawa matrix elements.
Epigenetic gene regulation linked to oncogenic pathways is an important focus of cancer research. KDM3A, a histone H3 lysine 9 (H3K9) demethylase, is known to have a pro-tumorigenic function. Here, ...we showed that KDM3A contributes to liver tumor formation through the phosphatidylinositol 3-kinase (PI3K) pathway, which is often activated in hepatocellular carcinoma. Loss of Kdm3a attenuated tumor formation in Pik3ca transgenic (Tg) mouse livers. Transcriptome analysis of pre-cancerous liver tissues revealed that the expression of activator protein 1 (AP-1) target genes was induced by PI3K activation, but blunted upon Kdm3a ablation. Particularly, the expression of Cd44, a liver cancer stem marker, was regulated by AP-1 in a Kdm3a-dependent manner. We identified Cd44-positive hepatocytes with epithelial-mesenchymal transition-related expression profiles in the Pik3ca Tg liver and confirmed their in vivo tumorigenic capacity. Notably, the number and tumor-initiating capacity of Cd44-positive hepatocytes were governed by Kdm3a. As a mechanism in Kdm3a-dependent AP-1 transcription, Kdm3a recruited c-Jun to the AP-1 binding sites of Cd44, Mmp7 and Pdgfrb without affecting c-Jun expression. Moreover, Brg1, a component of the SWI/SNF chromatin remodeling complex, interacted with c-Jun in a Kdm3a-dependent manner and was bound to the AP-1 binding site of these genes. Finally, KDM3A and c-JUN were co-expressed in 33% of human premalignant lesions with PI3K activation. Our data suggest a critical role for KDM3A in the PI3K/AP-1 oncogenic axis and propose a novel strategy for inhibition of KDM3A against liver tumor development under PI3K pathway activation.
•Gas and liquid slug lengths in a microreactor are estimated non-invasively.•The oscillation cycle time of feed pressure measurement is used for the estimation.•The estimation errors of the slug ...lengths were within 2% of the real values.
Microreactors with gas–liquid slug flow have an advantage over the conventional batch reactors in mass transfer between mutually immiscible fluids because of the internal circulation flow within the liquid slug. To realize stable long-term operation of microreactors with gas–liquid slug flow, the slug lengths in the microreactors have to be monitored and controlled, because they influence mass transfer performance. In this study, an experimental investigation is carried out to analyze the formation of gas–liquid slug flow in a T-shaped microreactor. The experimental result shows that the pressures in gas and liquid feeding tubes connected to the microreactor oscillate periodically along the formation of a pair of gas and liquid slugs. Based on this result, a method for estimating slug lengths from feed pressure measurements is developed. The method is non-invasive and does not affect slug formation or the manner of gas–liquid slug flow. Its effectiveness was assessed through experimental case studies using T-shaped microreactors having different gas–liquid confluence angles and different gas and liquid flow rates. The relative root mean square errors of estimated slug lengths were within 2% for one minute operation. The results clearly show that the proposed method can be applied to the real time monitoring of slug lengths.
Sharpin (Shank-associated RH domain-interacting protein, also known as SIPL1) is a multifunctional molecule that participates in various biological settings, including nuclear factor-κB signaling ...activation and tumor suppressor gene inhibition. Sharpin is upregulated in various types of cancers, including hepatocellular carcinoma (HCC), and is implicated in tumor progression. However, the exact roles of Sharpin in tumorigenesis and tumor progression remain largely unknown. Here we report novel mechanisms of HCC progression through Sharpin overexpression. In our study, Sharpin was upregulated in human HCC tissues. Increased Sharpin expression enhanced hepatoma cell invasion, whereas decrease in Sharpin expression by RNA interference inhibited invasion. Microarray analysis identified that Versican, a chondroitin sulfate proteoglycan that plays crucial roles in tumor progression and invasion, was also upregulated in Sharpin-expressing stable cells. Versican expression increased in the majority of HCC tissues and knocking down of Versican greatly attenuated hepatoma cell invasion. Sharpin expression resulted in a significant induction of Versican transcription synergistically with Wnt/β-catenin pathway activation. Furthermore, Sharpin-overexpressing cells had high tumorigenic properties in vivo. These results demonstrate that Sharpin promotes Versican expression synergistically with the Wnt/β-catenin pathway, potentially contributing to HCC development. A Sharpin/Versican axis could be an attractive therapeutic target for this currently untreatable cancer.
Abstract This article reports world averages of measurements of b-hadron, c-hadron, and $$\tau $$ τ -lepton properties obtained by the Heavy Flavor Averaging Group using results available through ...summer 2016. For the averaging, common input parameters used in the various analyses are adjusted (rescaled) to common values, and known correlations are taken into account. The averages include branching fractions, lifetimes, neutral meson mixing parameters, $$C\!P$$ C P violation parameters, parameters of semileptonic decays, and Cabbibo–Kobayashi–Maskawa matrix elements.
This paper reports world averages of measurements of
b
-hadron,
c
-hadron, and
τ
-lepton properties obtained by the Heavy Flavour Averaging Group using results available through September 2018. In ...rare cases, significant results obtained several months later are also used. For the averaging, common input parameters used in the various analyses are adjusted (rescaled) to common values, and known correlations are taken into account. The averages include branching fractions, lifetimes, neutral meson mixing parameters,
C
P
violation parameters, parameters of semileptonic decays, and Cabibbo–Kobayashi–Maskawa matrix elements.
Electromagnetic calorimeter for Belle II Belle-ECL; Aulchenko, V; Bobrov, A ...
Journal of physics. Conference series,
01/2015, Letnik:
587, Številka:
1
Journal Article
Recenzirano
Odprti dostop
The electromagnetic calorimeter of the BELLE II detector for experiments at Super B-factory SuperKEKB is briefly described. The project of the calorimeter upgrade to meet severe background conditions ...expected at the upgraded KEK B factory is presented.
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