The ice arches that usually develop at the northern and southern ends of Nares Strait play an important role in modulating the export of Arctic Ocean multi-year sea ice. The Arctic Ocean is evolving ...towards an ice pack that is younger, thinner, and more mobile and the fate of its multi-year ice is becoming of increasing interest. Here, we use sea ice motion retrievals from Sentinel-1 imagery to report on the recent behavior of these ice arches and the associated ice fluxes. We show that the duration of arch formation has decreased over the past 20 years, while the ice area and volume fluxes along Nares Strait have both increased. These results suggest that a transition is underway towards a state where the formation of these arches will become atypical with a concomitant increase in the export of multi-year ice accelerating the transition towards a younger and thinner Arctic ice pack.
The present guide provides a practical guide to conducting latent profile analysis (LPA) in the Mplus software system. This guide is intended for researchers familiar with some latent variable ...modeling but not LPA specifically. A general procedure for conducting LPA is provided in six steps: (a) data inspection, (b) iterative evaluation of models, (c) model fit and interpretability, (d) investigation of patterns of profiles in a retained model, (e) covariate analysis, and (f) presentation of results. A worked example is provided with syntax and results to exemplify the steps.
The North Atlantic Oscillation (NAO) is one of the most important modes of variability in the global climate system and is characterized by a meridional dipole in the sea level pressure field, with ...centers of action near Iceland and the Azores. It has a profound influence on the weather, climate, ecosystems, and economies of Europe, Greenland, eastern North America, and North Africa. It has been proposed that around 1980, there was an eastward secular shift in the NAO’s northern center of action that impacted sea ice export through Fram Strait. Independently, it has also been suggested that the location of its southern center of action is tied to the phase of the NAO. Both of these attributes of the NAO have been linked to anthropogenic climate change. Here the authors use both the one-point correlation map technique as well as empirical orthogonal function (EOF) analysis to show that the meridional dipole that is often seen in the sea level pressure field over the North Atlantic is not purely the result of the NAO (as traditionally defined) but rather arises through an interplay among the NAO and two other leading modes of variability in the North Atlantic region: the East Atlantic (EA) and the Scandinavian (SCA) patterns. This interplay has resulted in multidecadal mobility in the two centers of action of the meridional dipole since the late nineteenth century. In particular, an eastward movement of the dipole has occurred during the 1930s to 1950s as well as more recently. This mobility is not seen in the leading EOF of the sea level pressure field in the region.
Damage to myelin is a key feature of multiple sclerosis (MS) pathology. Magnetic resonance imaging (MRI) has revolutionized our ability to detect and monitor MS pathology in vivo. Proton density, T1 ...and T2 can provide qualitative contrast weightings that yield superb in vivo visualization of central nervous system tissue and have proved invaluable as diagnostic and patient management tools in MS. However, standard clinical MR methods are not specific to the types of tissue damage they visualize, and they cannot detect subtle abnormalities in tissue that appears otherwise normal on conventional MRIs. Myelin water imaging is an MR method that provides in vivo measurement of myelin. Histological validation work in both human brain and spinal cord tissue demonstrates a strong correlation between myelin water and staining for myelin, validating myelin water as a marker for myelin. Myelin water varies throughout the brain and spinal cord in healthy controls, and shows good intra‐ and inter‐site reproducibility. MS plaques show variably decreased myelin water fraction, with older lesions demonstrating the greatest myelin loss. Longitudinal study of myelin water can provide insights into the dynamics of demyelination and remyelination in plaques. Normal appearing brain and spinal cord tissues show reduced myelin water, an abnormality which becomes progressively more evident over a timescale of years. Diffusely abnormal white matter, which is evident in 20%–25% of MS patients, also shows reduced myelin water both in vivo and postmortem, and appears to originate from a primary lipid abnormality with relative preservation of myelin proteins. Active research is ongoing in the quest to refine our ability to image myelin and its perturbations in MS and other disorders of the myelin sheath.
Abstract
Nares Strait is a major pathway along which multi-year sea ice leaves the Arctic, an ice class that has seen a recent dramatic reduction in extent. The winds that blow along the strait play ...an important role in modulating this ice export as well as in establishing the Arctic’s largest and most productive polynya, the North Water, that forms at its southern terminus. However, its remote location has limited our knowledge of the winds along the strait. Here we use automatic weather station data from Hans Island, in the middle of the strait, to assess the ability of a set of atmospheric renalyses and analyses with a common lineage but with varying horizontal resolution to represent the variability in the wind field. We find that the flow is highly bidirectional, consistent with topographic channeling, with the highest wind speeds from the north and that a model resolution of ~ 9 km is required to capture the observed variability. The wind field at Hans Island is also found to be representative of variability in the flow along much of Nares Strait.
Water mass transformation in the Nordic and Barents Seas, triggered by air-sea heat fluxes, is an integral component of the Atlantic Meridional Overturning Circulation (AMOC). These regions are ...undergoing rapid warming, associated with a retreat in ice cover. Here we present an analysis covering 1950-2020 of the spatiotemporal variability of the air-sea heat fluxes along the region's boundary currents, where water mass transformation impacts are large. We find there is an increase in the air-sea heat fluxes along these currents that is a function of the currents' orientation relative to the axis of sea-ice change suggesting enhanced water mass transformation is occurring. Previous work has shown a reduction in heat fluxes in the interior of the Nordic Seas. As a result, a reorganization seems to be underway in where water mass transformation occurs, that needs to be considered when ascertaining how the AMOC will respond to a warming climate.
The Beaufort Sea High (BSH), an anti‐cyclone over the Beaufort Sea, is an important feature of the summer atmospheric circulation over the Arctic Ocean. For example, years characterized by low Arctic ...sea ice extent are typically associated with the presence of a stronger BSH; with the opposite occurring during years with high sea ice extent. In this paper, we show that there exists variability on the decadal time scale in the intensity and location of the summer BSH. We also show that there has been a trend towards a stronger summer BSH that began in the late 1990s. This trend is shown to be coincident with a tendency towards a reduction in cyclogenesis during the summer over the Beaufort Sea. We argue that that these trends are the result of a warming of the troposphere in the western Arctic and the concomitant reduction in baroclincity.
Key Points
There is a recent trend towards a more intense summer Beaufort Sea High
This trend is coincident with a reduction in cyclogenesis over the Beaufort Sea
Both trends are the result of a reduction in baroclinicity over the Arctic Ocean
The digital fabrication of oxide glasses by three-dimensional (3D) printing represents a major paradigm shift in the way glasses are designed and manufactured, opening opportunities to explore ...functionalities inaccessible by current technologies. The few enticing examples of 3D printed glasses are limited in their chemical compositions and suffer from the low resolution achievable with particle-based or molten glass technologies. Here, we report a digital light-processing 3D printing platform that exploits the photopolymerization-induced phase separation of hybrid resins to create glass parts with complex shapes, high spatial resolutions and multi-oxide chemical compositions. Analogously to conventional porous glass fabrication methods, we exploit phase separation phenomena to fabricate complex glass parts displaying light-controlled multiscale porosity and dense multicomponent transparent glasses with arbitrary geometry using a desktop printer. Because most functional properties of glasses emerge from their transparency and multicomponent nature, this 3D printing platform may be useful for distinct technologies, sciences and arts.
The rapidly expanding novel coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2, has challenged the medical community to an unprecedented degree. ...Physicians and health care workers are at added risk of exposure and infection during the course of patient care. Because of the rapid spread of this disease through respiratory droplets, health care workers who come in close contact with the upper aerodigestive tract during diagnostic and therapeutic procedures, such as otolaryngologists-head and neck surgeons, are particularly at risk. A set of safety recommendations was created based on a review of the literature and communications with physicians with firsthand knowledge of safety procedures during the COVID-19 pandemic.
A high number of health care workers were infected during the first phase of the pandemic in the city of Wuhan, China. Subsequently, by adopting strict safety precautions, other regions were able to achieve high levels of safety for health care workers without jeopardizing the care of patients. The most common procedures related to the examination and treatment of upper aerodigestive tract diseases were reviewed. Each category was reviewed based on the potential risk imposed to health care workers. Specific recommendations were made based on the literature, when available, or consensus best practices. Specific safety recommendations were made for performing tracheostomy in patients with COVID-19.
Preserving a highly skilled health care workforce is a top priority for any community and health care system. Based on the experience of health care systems in Asia and Europe, by following strict safety guidelines, the risk of exposure and infection of health care workers could be greatly reduced while providing high levels of care. The provided recommendations, which may evolve over time, could be used as broad guidance for all health care workers who are involved in the care of patients with COVID-19.
Remyelination is limited in the majority of multiple sclerosis (MS) lesions despite the presence of oligodendrocyte precursor cells (OPCs) in most lesions. This observation has led to the view that a ...failure of OPCs to fully differentiate underlies remyelination failure. OPC differentiation requires intricate transcriptional regulation, which may be disrupted in chronic MS lesions. The expression of few transcription factors has been differentially compared between remyelinating lesions and lesions refractory to remyelination. In particular, the oligodendrocyte transcription factor myelin regulatory factor (MYRF) is essential for myelination during development, but its role during remyelination and expression in MS lesions is unknown. To understand the role of MYRF during remyelination, we genetically fate mapped OPCs following lysolecithin-induced demyelination of the corpus callosum in mice and determined that MYRF is expressed in new oligodendrocytes. OPC-specific
Myrf
deletion did not alter recruitment or proliferation of these cells after demyelination, but decreased the density of new glutathione
S
-transferase π positive oligodendrocytes. Subsequent remyelination in both the spinal cord and corpus callosum is highly impaired following
Myrf
deletion from OPCs. Individual OPC-derived oligodendrocytes, produced in response to demyelination, showed little capacity to express myelin proteins following
Myrf
deletion. Collectively, these data demonstrate a crucial role of MYRF in the transition of oligodendrocytes from a premyelinating to a myelinating phenotype during remyelination. In the human brain, we find that MYRF is expressed in NogoA and CNP-positive oligodendrocytes. In MS, there was both a lower density and proportion of oligodendrocyte lineage cells and NogoA+ oligodendrocytes expressing MYRF in chronically demyelinated lesions compared to remyelinated shadow plaques. The relative scarcity of oligodendrocyte lineage cells expressing MYRF in demyelinated MS lesions demonstrates, for the first time, that chronic lesions lack oligodendrocytes that express this necessary transcription factor for remyelination and supports the notion that a failure to fully differentiate underlies remyelination failure.
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