Many important developments recently have been made in the treatment and prevention of coronary artery disease (CAD) in postmenopausal women. Substantial evidence supports focusing on comprehensive ...risk factor modification based on the "ABCs" of CAD management from the American College of Cardiology, the American Heart Association, and the American College of Physicians-American Society of Internal Medicine guidelines on chronic stable angina. This approach emphasizes cardiovascular risk factor interventions that include antiplatelet agents, angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, cholesterol-lowering medications, diabetes control, and counseling on diet and exercise. Despite the expanding available literature, many questions on CAD in postmenopausal women remain unanswered and await the publication of ongoing and future research. The unexpected findings from the HERS (Heart and Estrogen/progestin Replacement Study) failed to show a benefit of hormone replacement therapy (HRT) in reducing the risk of subsequent events in postmenopausal women with CAD, and instead reported an early increase in CAD events. Based on the data available so far, we advise against starting HRT in postmenopausal women with a recent coronary event for the sole purpose of CAD prevention. For women with acute coronary syndromes, prompt angiography and revascularization should be considered.
This paper presents a new methodology to estimate global tilted irradiation in 5-min steps using only global irradiation on the horizontal plane. The methodology is based on a combination of the two ...well-known conventional Perrin Brichambaut and Liu and Jordan models. Tilted irradiation is of great importance for the design and short-term performance assessment of fixed-tilt flat-plate collectors and photovoltaic (PV) systems. Intermediate key parameters of the state of the sky, referred to here as cloudiness factors, are determined and introduced to transform isotropic models into an anisotropic model. The results of the proposed model for all sky conditions with regard to normalized root mean square error (nRMSE), relative percentage error (RPE), normalized mean absolute error (nMAE) and coefficient of correlation (R2) range from 4.7 to 6.41%, 5.5–5.9%, 3.07–4.73% and 0.97 to 0.99, respectively, which are very accurate results, especially for such a short time step. A comparison with the best conventional models and even artificial neural network (ANN) models described in the literature has confirmed that the developed model has smaller errors.
•A model to estimate solar global radiation on tilted plane for 5 min is proposed.•The proposed model only uses global solar radiation as input and simplified equations.•The nRMSE range from 4.7 to 6.41% for three sites with different climatic conditions.•The prediction errors are lower than those obtained with ANN and classical methods.•The proposed model can be used for all sky conditions.
Display omitted
•First-principles calculations of electronic states of BP-QD with H2P are carryout.•The optical response through the imaginary part of dielectric function is obtaineds.•The rotations ...of H2P with respect to BP-QD do not change the binding energy.
Electronic and optical properties of phosphorene quantum dots functionalized with an organic molecule, porphyrin, are investigated using density functional theory with two different van der Waals functionals. The electronic structure of this complex is obtained and with this information, the real and imaginary parts of the dielectric function are calculated, from which, the interband optical response can be determined. Depending on the size of the quantum dot and the relative orientation between the dot and the organic molecule, it is found that the porphyrin physisorption leads to important modifications of the energy spectrum of the functionalized blue phosphorene quantum dots. These changes reflect in the optical response of the complex which shows features that come from both the blue phosphorene structure and the organic molecule. It is also found that the rotations of the molecule with respect to the phosphorene quantum dot do not practically alter the value of the binding energy.
Abstract
The immunity conferred by SARS-CoV-2 vaccines and infections reduces the transmission of the virus. To answer how the effect of immunity is shared between a reduction of infectiousness and ...an increased protection against infection, we examined >50,000 positive cases and >110,000 contacts from Geneva, Switzerland (June 2020 to March 2022). We assessed the association between secondary attack rate (i.e. proportion of new cases among contacts) and immunity from natural infection and/or vaccination, stratifying per four SARS-CoV-2 variants and adjusting for index cases and contacts’ socio-demographic characteristics and the propensity of the contacts to be tested. Here we show that immunity protected contacts from infection, rather than reducing infectiousness of index cases. Natural infection conferred the strongest immunity. Hybrid immunity did not surpass recent infection. Although of smaller amplitude, the reduction in infectiousness due to vaccination was less affected by time and by the emergence of new SARS-CoV-2 variants than the susceptibility to infection. These findings support the role of vaccine in reducing infectiousness and underscore the complementary role of interventions reducing SARS-CoV-2 propagation, such as mask use or indoor ventilation.
We present the complete mitochondrial genome of
from Salinas, CA. The mitochondrial genome of
is circular, AT rich (78.1%), and 16,671 bp in length. It consists of 13 protein-coding, 22 transfer RNA, ...and 2 ribosomal RNA genes and is identical in gene content to
sp.
We present a new educational initiative called Meet-U that aims to train students for collaborative work in computational biology and to bridge the gap between education and research. Meet-U mimics ...the setup of collaborative research projects and takes advantage of the most popular tools for collaborative work and of cloud computing. Students are grouped in teams of 4-5 people and have to realize a project from A to Z that answers a challenging question in biology. Meet-U promotes "coopetition," as the students collaborate within and across the teams and are also in competition with each other to develop the best final product. Meet-U fosters interactions between different actors of education and research through the organization of a meeting day, open to everyone, where the students present their work to a jury of researchers and jury members give research seminars. This very unique combination of education and research is strongly motivating for the students and provides a formidable opportunity for a scientific community to unite and increase its visibility. We report on our experience with Meet-U in two French universities with master's students in bioinformatics and modeling, with protein-protein docking as the subject of the course. Meet-U is easy to implement and can be straightforwardly transferred to other fields and/or universities. All the information and data are available at www.meet-u.org.
PDF
