This study started from a fig-derived product project in the 2022–2026 Strategic Plan from Sonora, Mexico, to develop technological solutions in complex environments and provide a global panorama ...from the industry to the prevailing situation in Valle del Mayo. A technological solution is based on a graphical interface to support decision-making in fig supply, production and distribution in the administration process, given that the main problem has been the lack of a processing plant with a sustainable approach. Four options were set up for nine producers—figs in syrup, dehydrated, marmalade, compost—based on the system dynamics methodology to solve the problem of factory installation. Six stages were followed: (1) mapping the system to determine variables and parameters; (2) constructing the causal diagram; (3) developing the flow and level diagram and model equations; (4) simulating and validating the current model; (5) designing policies and evaluating scenarios using a multi-criteria analysis; and (6) developing the graphical interface. The main conclusions show that fig-derived products and their distribution can feature in diverse markets in a graphics environment supported by complex mathematical models in the supply chain along with the capacity to generate income into utilities to support the decision of the physical factory prior to important investments.
Sugarcane cultivation requires correct fertilizer rates. However, when nutrients are not available, or there is over-fertilization, the yields are significantly reduced and the environmental burden ...increase. In this study, it is proposed a decision support system (DSS) for the correct NPK (nitrogen, phosphorus and potassium) fertilization. The DSS consists of two fuzzy models; the edaphic condition model (EDC-M) and the NPK fertilization model (NPK-M). The DSS using parameters from soil analysis and is based on the experience of two groups of experts to avoid the bias to the reality of a single group of professionals. The results of the DSS are compared with the results of soil analysis and those of the group of experts. One hundred and sixty tests were developed in the NPK-M. The N rate shows R
2
=0.981 for the DSS and R
2
=0.963 for soil analyzes. The P rate shows R
2
=0.9702 for the DSS and R
2
=0.9183 for the soil analyzes. The K rate shows R
2
=0.9691 for the DSS and R
2
=0.9663 for the soil analyzes. Environmental results indicate that the estimated rates with the DSS do reduce the environmental impact on the tests performed.
Cervical cancer is the fourth most frequent neoplasm among women in terms of incidence and mortality. Health-related quality of life (HRQL) is an important outcome in oncology. The QLQ-CX24 ...instrument was developed to measure HRQL in patients with cervical cancer, and its Mexican-Spanish version had not been validated.
Between March 2018 and May 2019, Mexican women older than 18, with any-stage cervical cancer were invited to participate in the study. Patients answered the QLQ-C30 and QLQ-CX24 questionnaires. Current tests for psychometric and clinical validation were performed.
Three hundred and thirty patients with cervical cancer were included in this study. All women invited to participate accepted and were included. The QLQ-CX24 internal consistency test demonstrated adequate convergent (Spearman correlation coefficient 0.001-0.847) and divergent validity (Spearman correlation coefficient <0.0001-0.45). Cronbach's alpha coefficients of the three multi-item scales were >0.7 (minimum 0.76, maximum 0.89). Four scales of the QLQ-CX24 distinguished patients in different clinical stages. The evaluation of responsiveness demonstrated that the peripheral neuropathy scale was sensitive to change over time during chemo-radiation therapy. Six scales of the QLQ-CX24 instrument were associated with survival.
The Mexican-Spanish version of the QLQ-CX24 questionnaire is reliable and valid for the assessment of HRQL in patients with cervical cancer.
The cane sugar industry in Mexico depends heavily on the supply of energy, fossil fuels and material resources for its proper operation. The overuse of these resources plus the technical and ...technological deficiency causes severe environmental consequences. This scientific work aims to analyze the environmental damage attributable to cane sugar production following the life cycle assessment (LCA) methodology. System boundaries include sugarcane growing and harvesting, sugarcane transportation, sugar milling and electricity cogeneration from bagasse. The associated emissions were acquired from the SimaPro-Ecoinvent database, the Roundtable on Sustainable Biofuels (RSB) and the Agroscope Reckenholz-Tänikon Research Station (ART). The life cycle impact assessment (LCIA) was carried out by SimaPro 8.3.0 software and the characterization method used was IMPACT 2002+. The results show that sugarcane growing and harvesting stage provides the most harmful environmental impacts (52%) followed by electricity cogeneration (25.7%), sugarcane transportation (12.1%) and finally, sugar milling (10.2%). Regarding the environmental contributions at the endpoint categories, the highest percentage of impacts is found in the Human health category (53%), followed by Climate change (21%), Ecosystem quality (16%) and Resources (10%). The LCA in cane sugar production can support the decision-making process to deal with this environmental problem.
Introducción. La evaluación enfocada extendida con ecografía en trauma (E-FAST, extended focused assessment with sonography for trauma) puede realizarse con entrenamiento mínimo y lograr resultados ...ideales. Su fácil transporte permite usarla en entornos austeros, como el Caribe colombiano, donde muchos centros no disponen de servicio radiológico las 24 horas. El objetivo de este estudio fue determinar el rendimiento del uso de E-FAST por residentes de cirugía general de segundo año en la evaluación del trauma en urgencias.
Métodos. Estudio observacional retrospectivo que evaluó el rendimiento diagnóstico de E-FAST con Butterfly IQ, en pacientes con trauma toracoabdominal que acudieron a un centro de referencia del Caribe colombiano, entre noviembre de 2021 y julio de 2022. Se evaluaron sensibilidad, especificidad, valores predictivos positivo y negativo, comparando la descripción de la ecografía con los hallazgos intraoperatorios o imagenología convencional.
Resultados. Se incluyeron un total de 46 pacientes, con una media de edad de 31,2 ± 13,8 años, siendo el 87,4 % (n=39) hombres. El principal mecanismo de trauma fue penetrante (n=32; 69,5 %). Se encontró que el 80,4 % (n=37) de los pacientes tuvo resultado E-FAST positivo, y que, de estos, el 97 % (n=35) tuvo un hallazgo positivo intraoperatorio. Se calculó una sensibilidad de 92,1 %, especificidad de 75 %, valor predictivo positivo de 94,6 % y negativo de 66,6; la razón de verosimilitud positiva fue de 3,68 y la negativa de 0,10.
Conclusión. Los residentes de cirugía general están capacitados para realizar exploraciones E-FAST precisas. El ecógrafo portátil es una herramienta de diagnóstico eficaz para pacientes traumatizados.
In this paper we present a technique to measure the radius of curvature of a test sphere based on the relation between acquired images of a circular cosine fringe pattern and size of virtual image ...formed on the calibration test surface. Radius of curvature is calculated with the exact equation proposed, using the parameters of the optical setup. Fringe pattern evaluation was performed by locating extrema indices. The mathematical formulation as well as the experimental setup and results are presented. After applying a linear fit algorithm to the data as a method of compensation, obtained results show an error within the tolerance established by the ISO 10343 specifications.
Mitotic arrest deficient 1 (MAD1), a protein of the mitotic spindle assembly checkpoint (SAC), recognizes MAD2 through two leucine zippers, transporting and activating MAD2, which promotes a ...metaphase arrest signal. A single nucleotide polymorphism of MAD1 was found to affect the SAC function that could be involved in a poor response to therapeutic agents that alter the dynamics of microtubules.
The aim of this study was to examine the relationship of the polymorphism MAD1 1673 G → A (rs1801368) with the efficiency of the SAC and the generation of aneuploidies and with the therapeutic response of patients with ovarian cancer.
The polymorphism was evaluated in 144 healthy individuals and 91 patients. Mitotic arrest and the presence of errors in segregation were analyzed in cultured human lymphocytes treated with nocodazole and paclitaxel. Errors in segregation were also evaluated in 27 biopsies of patients.
Allele frequencies in healthy individuals were G: 50%, A: 50%, whereas in the patients they were G: 38%, A: 62% (P<0.05). The percentage of cells with mitotic arrest was higher among GG cells (P<0.05). The frequency of micronuclei and nondisjunction events increased in AA cells (P<0.05). Tumors from polymorphic patients had a higher percentage of aneuploid cells (P<0.05). The GG patients showed a higher biochemical response, optimal cytoreduction, and sensitivity to the treatment. There were no differences in progression-free or overall survival between both groups.
The polymorphism MAD1 1673 G → A affects SAC functionality, increasing the frequency of aneuploid cells. This polymorphism modifies the response to agents that alter the dynamics of microtubules in patients with ovarian cancer.
The aetiological relationship between human papillomavirus (HPV) infection and cervical cancer (CC) is widely accepted. Our goal was to determine the prevalence of HPV types in Mexican women ...attending at the Mexican Institute for Social Security from different areas of Mexico.
DNAs from 2,956 cervical samples were subjected to HPV genotyping: 1,020 samples with normal cytology, 931 with low-grade squamous intraepithelial lesions (LGSIL), 481 with high grade HGSIL and 524 CC.
Overall HPV prevalence was 67.1%. A total of 40 HPV types were found; HPV16 was detected in 39.4% of the HPV-positive samples followed by HPV18 at 7.5%, HPV31 at 7.1%, HPV59 at 4.9%, and HPV58 at 3.2%. HPV16 presented the highest prevalence both in women with altered or normal cytology and HPV 18 presented a minor prevalence as reported worldwide. The prevalence ratio (PR) was calculated for the HPV types. The analysis of PR showed that HPV16 presents the highest association with CC, HPV 31, -33, -45, -52 and -58 also demonstrating a high association.
The most prevalent HPV types in cervical cancer samples were -16, -18, -31, but it is important to note that we obtained a minor prevalence of HPV18 as reported worldwide, and that HPV58 and -52 also were genotypes with an important prevalence in CC samples. Determination of HPV genotypes is very important in order to evaluate the impact of vaccine introduction and future cervical cancer prevention strategies.
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