Clinical parameters and proteins have recently been suggested as possible causes of radiotherapy (RT) resistance in cervical carcinoma (CC). The objective of the present study was to validate ...prognostic biomarkers of radiation resistance.
The present prospective study included patients undergoing RT with curative intent for histologically proven locally advanced squamous cell CC. Tissues and blood samples were systematically collected before RT initiation. Immuno-histochemistry was performed (IGF-IR α and β, GAPDH, HIF-1 alpha, Survivin, GLUT1, CAIX, hTERT and HKII). Response to radiation was assessed through tumour response 3 months after RT completion, through overall survival (OS) and through progression-free survival (PFS).
One hundred forty nine patients with a mean age of 46 years were included, with FIGO IIB (n = 53) and FIGO IIIB (n = 96) CCs. 61 patients were treated with exclusive RT + brachytherapy and 88 underwent chemo-radiotherapy + brachytherapy. Our findings suggest an association between hemoglobin level (Hb) (>11 g/dL) and 3 months complete response (p = 0.02). Hb level < 11 g/dL was associated with decreased PFS (p = 0.05) and OS (p = 0.08). Overexpression of IGF-1R β was correlated with a decreased OS (p = 0.007). Overexpression of GLUT1 was marginally correlated with reduced OS (p = 0.05). PFS and OS were significantly improved in patients undergoing chemoradiation versus exclusive radiotherapy (PFS: p = 0.04; OS: p = 0.01).
IGF-1R β overexpression and Hb level (≤11 g/dl) were associated with poor prognosis, and thus appear to be possible interesting biomarkers of radiation resistance. Our results corroborate previous pre-clinical studies suggesting IGF-1R and hypoxia to be part of the biological pathways leading to radio-resistance.
Since theorem 1 of (Elhadj and Sprott, 2012) is incorrect, some of the systems found in the article (Casas-García et al. 2016) may have homoclinic or heteroclinic orbits and may seem chaos in the ...Shilnikov sense. However, the fundamental contribution of our paper was to find ten simple, three-dimensional dynamic systems with non-linear quadratic terms that have an asymptotically stable equilibrium point and are chaotic, which was achieved. These were obtained using the Monte Carlo method applied specifically for the search of these systems.
Based on a wider systematic search on a family of 3-dimensional systems with quadratic nonlinearities, three new simple chaotic systems were found. One of them has the unusual feature of having a ...stable equilibrium point, and it is the simplest one of other chaotic flows with this property. The others have some interesting special properties.
Abstract In this paper ten new chaotic nonlinear autonomous systems are presented. These systems were found by using the Monte Carlo method and they characterized by having one of their equilibrium ...points asymptotically stable. These new systems does not present chaos in the sense of Shilnikov, but their bifurcation diagrams show a period-doubling route towards chaos. Kaplan- Yorke dimensions were also calculated, which is fractional order enclosed in a range of 2-3.
High-sensitivity double-gap phenolic resistive plate chambers (RPCs) are studied for the Phase-2 upgrade of the Compact Muon Solenoid (CMS) muon system at high pseudorapidity
η
. Whereas the present ...CMS RPCs have a gas gap thickness of 2 mm, we propose to use thinner gas gaps, which will improve the performance of these RPCs. To validate this proposal, we constructed double-gap RPCs with two different gap thicknesses of 1.2 and 1.4 mm by using high-pressure laminated plates having a mean resistivity of about 5 × 10
10
Ω-cm. This paper presents test results using cosmic muons and
137
Cs gamma rays. The rate capabilities of these thin-gap RPCs measured with the gamma source exceed the maximum rate expected in the new high-
η
endcap RPCs planned for future Phase-2 runs of the Large Hadron Collider (LHC).
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