An infrared laser system with variable wavelength is used to study fundamental properties of silicon microstrip detectors. Results of measurements concerning charge sharing among adjacent readout ...strips and depletion mapping are presented. The results are interpreted in a model framework which describes the charge sharing with the help of the so-called
η-function. The wavelength dependence of the
η-function is studied. Surface effects important for short wavelengths are observed.
The design of the double-sided microstrip detectors for the HERA-B experiment at DESY is discussed, in particular with respect to the strong requirements imposed by the high radiation environment and ...by the challenging mechanical construction. The detectors are tested with an infrared laser setup and first results from operation in the experiment in 1997 are presented.
The HERA-B vertex detector system Bauer, C.; Bräuer, M.; Glebe, T. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
10/2000, Letnik:
453, Številka:
1
Journal Article
Recenzirano
The HERA-B experiment is being built to measure CP violation in the B-system using internal targets at the HERA proton storage ring at DESY. This paper presents an overview of its vertex detector ...which – apart from an additional superlayer – is realized by a system of 20 Roman pots containing seven superlayers of double-sided silicon microstrip detectors that are operated at 10 mm distance from the proton beam in a high-radiation environment.
Status of the HERA-B vertex detector Bauer, C; Bräuer, M; Glebe, T ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
06/2000, Letnik:
447, Številka:
1
Journal Article
Recenzirano
The HERA-B experiment is a forward magnetic spectrometer with good particle identification for hadrons and leptons designed to study violation of CP symmetry in the neutral B meson system. The ...silicon vertex detector operates in a high-rate environment similar to the ones expected at LHC. In this paper we report on our R&D on strip detector design, frontend ASICs, mechanical and thermal engineering, low-mass RF shielding of the HERA proton beam and on the status of our reconstruction software. First experiences with last year's installation are discussed.
First experience and results from the HERA- B vertex detector system Bauer, C.; Baumann, I.; Bräuer, M. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
11/1998, Letnik:
418, Številka:
1
Journal Article
Recenzirano
The HERA-
B collaboration is building a detector to realize the ambitious goal of observing CP violation in decays of neutral B-mesons. A central element of the apparatus is the silicon vertex ...detector used to selectively trigger on these decays in a high charged particle multiplicity background environment and to reconstruct secondary vertices from such decays with high precision. The vertex detector, the supporting infrastructure and first results using prototype detectors are described. Results include imaging of the proton interaction region on the HERA-
B target, hit distributions in the detector planes, and alignment of the detectors with each other and the target.
Gluing silicon with silicone Abt, I.; Fox, H.; Moshous, B. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
07/1998, Letnik:
411, Številka:
1
Journal Article
Recenzirano
Problems and solutions concerning the gluing of silicon detectors are discussed. The R & D work for the HERA-
B vertex detector system led to gluing studies with epoxy and silicone-based adhesives ...used on ceramics and carbon fibre. The HERA-
B solution using a silicone glue is presented.
The HERA-B vertex detector Masciocchi, S.; Abt, I.; Brauer, M. ...
1999 IEEE Nuclear Science Symposium. Conference Record. 1999 Nuclear Science Symposium and Medical Imaging Conference (Cat. No.99CH37019),
1999, Letnik:
1
Conference Proceeding
The design of the vertex detector of the HERA-B experiment at DESY is reviewed, and its components are described. The silicon microstrip detectors were optimized for radiation hardness: results from ...irradiation tests, reproducing the challenging situation in the experiment, are presented. Since spring 1999, much of the system has been installed and is operational. The detector performance and results from track and vertex reconstruction are presented.
In previous clinical trials involving children with X-linked severe combined immunodeficiency (SCID-X1), a Moloney murine leukemia virus-based γ-retrovirus vector expressing interleukin-2 receptor ...γ-chain (γc) complementary DNA successfully restored immunity in most patients but resulted in vector-induced leukemia through enhancer-mediated mutagenesis in 25% of patients. We assessed the efficacy and safety of a self-inactivating retrovirus for the treatment of SCID-X1.
We enrolled nine boys with SCID-X1 in parallel trials in Europe and the United States to evaluate treatment with a self-inactivating (SIN) γ-retrovirus vector containing deletions in viral enhancer sequences expressing γc (SIN-γc).
All patients received bone marrow-derived CD34+ cells transduced with the SIN-γc vector, without preparative conditioning. After 12.1 to 38.7 months of follow-up, eight of the nine children were still alive. One patient died from an overwhelming adenoviral infection before reconstitution with genetically modified T cells. Of the remaining eight patients, seven had recovery of peripheral-blood T cells that were functional and led to resolution of infections. The patients remained healthy thereafter. The kinetics of CD3+ T-cell recovery was not significantly different from that observed in previous trials. Assessment of insertion sites in peripheral blood from patients in the current trial as compared with those in previous trials revealed significantly less clustering of insertion sites within LMO2, MECOM, and other lymphoid proto-oncogenes in our patients.
This modified γ-retrovirus vector was found to retain efficacy in the treatment of SCID-X1. The long-term effect of this therapy on leukemogenesis remains unknown. (Funded by the National Institutes of Health and others; ClinicalTrials.gov numbers, NCT01410019, NCT01175239, and NCT01129544.).
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