In the electronics industry, the efficient recovery and capture of sulfur hexafluoride (SF6) from SF6/N2 mixtures is of great importance. Herein, three metal–organic frameworks with fine‐tuning pore ...structures, Cu(peba)2, Ni(pba)2, and Ni(ina)2, were designed for SF6 capture. Among them, Ni(ina)2 has perfect pore sizes (6 Å) that are comparable to the kinetic diameter of sulfur hexafluoride (5.2 Å), affording the benchmark binding affinity for SF6 gas. Ni(ina)2 exhibits the highest SF6/N2 selectivity (375.1 at 298 K and 1 bar) and ultra‐high SF6 uptake capacity (53.5 cm3 g−1 at 298 K and 0.1 bar) at ambient conditions. The remarkable separation performance of Ni(ina)2 was verified by dynamic breakthrough experiments. Theoretical calculations and the SF6‐loaded single‐crystal structure provided critical insight into the adsorption/separation mechanism. This porous coordination network has the potential to be used in industrial applications.
The metal–organic framework (MOF) Ni(ina)2 has pore sizes (6 Å) that are perfectly compatible with the kinetic diameter of sulfur hexafluoride (5.2 Å), affording the benchmark binding affinity for this potent greenhouse gas that is used in the electronics industry.
Four unprecedented 3d-4f hetero-octanuclear family-type complexes {Cu(L)Ln(NO3)3}2Cu(L)Ln(NO3)32 (Ln = Sm (1), Eu (2), Tb (3) and Dy (4)) were synthesized and characterized via elemental analyses, ...PXRD, FT-IR, UV–Vis spectroscopy. In addition, while studying the crystal structures, the supramolecular interactions and spectral properties of complexes 1–4 were studied in detail.
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•Four unprecedented 3d-4f family-type complexes {Cu(L)Ln(NO3)3}2Cu(L)Ln(NO3)32 (Ln = Sm (1), Eu (2), Tb (3) and Dy (4)) were synthesized.•The structure of each complex was composed of a neutral dimer {Cu(L)Ln(NO3)3}2 unit and two independent Cu(L)Ln(NO3)3 units.•The UV–Vis titration experiments, crystal structure and supramolecular interactions were investigated in detail.
Four unprecedented 3d-4f hetero-octanuclear family-type complexes {Cu(L)Ln(NO3)3}2Cu(L)Ln(NO3)32 (Ln = Sm (1), Eu (2), Tb (3) and Dy (4)) were synthesized by an unsymmetric single salamo-like ligand H2L (6-Methoxy-6′-ethoxy-2,2′-ethylenedioxybis(nitrilomethylidyne)diphenol) with Cu(OAc)2·H2O and Ln(NO3)3·6H2O (Ln = Sm, Eu, Tb and Dy), respectively. X-ray crystallography revealed that each hetero-octanuclear 3d-4f metal complexes {Cu(L)Ln(NO3)3}2Cu(L)Ln(NO3)32 contains one neutral dimer {Cu(L)Ln(NO3)3}2 unit and two independent Cu(L)Ln(NO3)3 units. At the same time, the four Cu(II) atoms of the complexes 1–4 have four- and five-coordinated configurations, while the four Ln(III) atoms have only one configuration, all of which are ten-coordinated. The structures of the four complexes 1–4 were characterized via elemental analyses, PXRD, FT-IR and UV–Vis spectroscopy. In addition, while studying the crystal structure, the supramolecular interactions and spectral properties of the complexes 1–4 were studied in detail.
Di(2-ethylhexyl)phthalate (DEHP) is widely used as a plasticizer to improve product flexibility and workability. Lycopene (LYC) is a natural compound and has promising preventive potentials, ...especially antireproductive toxicity, but the specific underlying mechanism is yet to be fully defined. Our study investigated the effect of LYC on DEHP-induced spermatogenesis disorders. Male ICR mice were treated with DEHP (500 or 1000 mg/kg BW/day) and/or LYC (5 mg/kg BW/day) for 28 days. Our results indicated that LYC could relieve the DEHP-induced injury of seminiferous tubules and spermatogenic cells, swelling of endoplasmic reticulum (ER), and an increase of mitochondria. LYC prevented increased levels of nuclear damage to DNA and the deformity rate and decreased values of sperm motility, number, and density. Moreover, LYC treatment decreased DEHP-induced nuclear accumulation of aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT), and the expressions of their downstream target genes such as cytochrome P450-dependent monooxygenases (CYP) 1A1, 1A2, and 1B1 were markedly reduced to normal in the LYC treatment group. Our study showed that LYC can prevent DEHP-induced spermatogenic disorders via an AHR/ARNT signaling system. This study provided new evidence of AHR as a target for LYC, which can prevent DEHP-induced toxicity.
As a plasticizer, di(2-ethylhexyl) phthalate (DEHP) is the most usually used phthalate. Leydig cell is a male-specific cell, which plays a principal role in spermatogenesis and masculinization by ...the androgens of synthesis and secretion. Numerous researchers have indicated that DEHP can result in testicular toxicity by inducing oxidative stress. Lycopene (LYC) is a possible treatment option for male infertility due to its natural antioxidant properties. Our study was aimed to investigate whether LYC could rescue DEHP-induced Leydig cell damage. The mice were treated with DEHP (500 mg/kg BW/day or 1000 mg/kg BW/day) and/or LYC (5 mg/kg BW/day) for 28 days. We found that LYC attenuated DEHP-induced Leydig cell damage. Moreover, the protective role of LYC was verified by the histopathological and ultrastructural analysis of the Leydig cell. LYC suppressed oxidative stress that was induced by DEHP. In the Leydig cell, the expressions of the nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream target genes were improved through LYC-mediated protection in DEHP-induced Leydig cell damage. Our findings indicated that LYC could increase the antioxidant capacity via mediating Nrf2 signaling pathway, thereby attenuating DEHP-induced Leydig cell damage.
Di (2-ethylhexyl) phthalate (DEHP) is an environmentally persistent and bioaccumulative plasticizer. Accumulation of DEHP in the body can eventually cause kidney damage. As a type of natural ...carotenoid, lycopene (LYC) has a potential protective effect on renal cells, but the protective mechanism has not yet been elucidated. The major goal of this study was to see how effective LYC was at treating DEHP-induced nephrotoxicity in mice. ICR mice were treated with DEHP (500 mg/kg BW/day or 1000 mg/kg BW/day) or LYC (5 mg/kg BW/day) for 28 days. Through histopathology and ultrastructure, we found that LYC attenuated DEHP-induced renal tubular cell and glomerular damage. LYC relieved DEHP-induced kidney injury evidenced by lower levels of blood urea nitrogen (Bun), creatinine (Cre), and uric acid (Uric). Meanwhile, the reduced expression of kidney injury molecule-1 (Kim-1) also supported it. Notably, LYC can alleviate the activity or content of cytochrome P450 system (CYP450s) interfered with by DEHP. In addition, LYC treatment reduced nuclear accumulation of DEHP-induced aromatic hydrocarbon receptor (AhR) and AhR nuclear transporter (Arnt), and its downstream target genes such as cytochrome P450-dependent monooxygenase (CYP) 1A1, 1A2, and 1B1 expression significantly decreased to normal in the LYC treatment group. In summary, LYC can mediate the AhR/Arnt signaling system to prevent kidney toxicity in mice caused by DEHP exposure.
A new homo-trinuclear Ni(II) half-salamo-based complex Ni3(L)2(μ-OAc)2(OAc)2(CH3OH)2·2CH3OH was synthesized via the reaction of a tridentate ligand HL (2-O-(1-ethyloxyamide)oxime-4-bromophenol) and ...Ni(OAc)2·4H2O, and characterized using elemental analyses, IR spectra, UV-Vis absorption spectra, X-ray crystallography, and Hirshfeld analysis. Interestingly, single-crystal X-ray analysis showed that the two acetate molecules were bonded simultaneously with the Ni(II) atoms by mono-dentate chelating and bidentate bridging coordination modes, respectively, and the resulting hexa-coordinate geometries were ultimately formed. Furthermore, the Hirshfeld analysis of the complex was studied. Compared with HL, the complex fluorescence intensity was significantly lowered, indicating that the Ni(II) ions have fluorescence quenching characteristics.
Di(2-ethylhexyl) phthalate (DEHP) is a widespread environmental contaminant, which is mainly used as a plasticizer to improve the flexibility of products; however, its extensive use causes male ...reproductive damage. Lycopene (LYC) has a protective effect on male reproductive toxicity. Nevertheless, the underlying role of LYC in DEHP-induced spermatogenic cell damage remains unclear. Our study aimed to investigate the role of LYC in DEHP-induced spermatogenic cell damage and its underlying mechanism. Male ICR mice were treated with LYC (5 mg kg-1) and/or DEHP (500 mg kg-1 or 1000 mg kg-1) for 28 days. The results showed that LYC alleviated the DEHP-induced decrease in mitochondria volume density and mitochondrial membrane potential (ΔΨm). Subsequently, LYC prevented the DEHP-induced PGC-1α-mediated reduction in mitochondrial biogenesis in spermatogenic cells. LYC exhibited a potential preventive effect against DEHP-induced mitophagy caused by mitochondrial dynamics disorder in the spermatogenic cells. Meanwhile, LYC relieved DEHP-induced mitochondrial stress in the spermatogenic cells by activating UPRmt. These results proved that mitochondrial quality control may be related to the beneficial role of LYC in preventing DEHP-induced mitophagy in spermatogenic cells. This study provides new evidence of mitochondrial quality control as a target for LYC treatment, which can prevent DEHP-induced toxicity.
A highly sensitive and efficient fluorescence-ultraviolet dual channel chemical sensor H
2
L based on the salamo-like bisoxime (6,6′-dimethoxy-2, 2′-ethylenediyldioxybis(nitrilomethylidyne)diphenol) ...was synthesized, Cu
2+
and S
2−
ions can be detected respectively. For the identification of metal cations, the Cu
2+
can quench the fluorescence intensity of probe H
2
L at the excitation wavelength of 311 nm, and when the same equivalent of EDTA was added, the fluorescence intensity of L-Cu complex returned to its original intensity practically, completing the fluorescence "OFF-ON-OFF" cycle after adding the same amount of Cu
2+
again. The mechanism was confirmed by high resolution mass spectrometry, and it was concluded that the probe H
2
L and Cu
2+
formed a complex. For the identification of anions, UV-Vis spectral identification and naked-eye recognition for S
2−
were performed. The binding mode of the probe to the sulfur anion and the recognition mechanism were confirmed by
1
H NMR titration. In addition, the probe H
2
L showed high selectivity and sensitivity to Cu
2+
and S
2−
, the detection limits of L-Cu and L-S systems toward Cu
2+
and S
2−
are 46 and 25 nM respectively. In terms of application, the content of Cu
2+
and S
2−
in different water samples (distilled water, Yellow River water and tap water) with probe H
2
L was successfully tested. These results indicated that the probe H
2
L can be used as a highly selective and sensitive dual channel sensor to detect both Cu
2+
and S
2−
ions in the environment and biological systems.
In this paper, drop impact onto a sphere is numerically investigated at moderate Reynolds and Weber numbers. It is naturally expected that the aspect ratio of the sphere to the drop,
...$\unicodeSTIX{x1D706}_{r}$
, would make a big difference to drop spreading and retraction on the sphere, compared with drop impact onto a flat substrate. To quantitatively assess the effect of
$\unicodeSTIX{x1D706}_{r}$
, a diffuse-interface immersed-boundary method is adopted after being validated against experiments. With the help of numerical simulations, we identify the key regimes in the spreading and retraction, analyse the results by scaling laws, and quantitatively evaluate the effect of
$\unicodeSTIX{x1D706}_{r}$
on the impact dynamics. We find that the thickness of the liquid film spreading on the sphere can be well approximated by
$h_{L,\infty }(1+3/4\unicodeSTIX{x1D706}_{r}^{-3/2})$
, where
$h_{L,\infty }$
represents the film thickness of drop impact on a flat substrate. At the early stage of spreading, the temporal variation of the wetted area is independent of
$\unicodeSTIX{x1D706}_{r}$
when the time is rescaled by the thickness of the liquid film. Drops are observed to retract on the sphere at a roughly constant speed, and the predictions of theoretical analysis are in good agreement with numerical results.
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