Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, ...including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. These biological activities depend upon the type of flavonoid, its (possible) mode of action, and its bioavailability. These cost-effective medicinal components have significant biological activities, and their effectiveness has been proved for a variety of diseases. The most recent work is focused on their isolation, synthesis of their analogs, and their effects on human health using a variety of techniques and animal models. Thousands of flavonoids have been successfully isolated, and this number increases steadily. We have therefore made an effort to summarize the isolated flavonoids with useful activities in order to gain a better understanding of their effects on human health.
Steviosides, rebaudiosides and their analogues constitute a major class of naturally occurring biologically active diterpene compounds. The wide spectrum of pharmacological activity of this group of ...compounds has developed an interest among medicinal chemists to synthesize, purify, and analyze more selective and potent isosteviol derivatives. It has potential biological applications and improves the field of medicinal chemistry by designing novel drugs with the ability to cope against resistance developing diseases. The outstanding advancement in the design and synthesis of isosteviol and its derivative has proved its effectiveness and importance in the field of medicinal chemical research. The present review is an effort to integrate recently developed novel drugs syntheses from isosteviol and potentially active pharmacological importance of the isosteviol derivatives covering the recent advances.
The discharge of unsafe color dyes into the effluents of various industries can harm the environment and human health and therefore needs remediation. The current research assesses the ...environmental friendly decontamination of the Alizarin Red S (ARS) dye from industrial aqueous effluents by powder bark of a low-cost and indigenous plant,
Ficus religiosa,
as a biosorbent. The biosorbent was processed, powdered, and then characterized via SEM and FTIR spectroscopy before and after exposure to ARS. For maximum dye-decontamination of industrial effluents, adsorption parameters including dosage of the biosorbent, contact time between the dye and the biosorbent, shaking time and temperature of the adsorption process were optimized. SEM images confirmed the presence of high surface area active binding sites, and FTIR analysis shows that the adsorption of ARS on the adsorbent is due to groups like ‒OH, –NH, –CH, C=O and C=C. The kinetics study of the adsorption follows pseudo-second order kinetic model. Best fit isotherm to the equilibrium data was obtained for Langmuir and Freundlich models. The decontamination ARS from aqueous phase by the adsorption process could be an inexpensive and viable way of protecting humans from carcinogenicity, DNA mutagenicity, jaundices, allergies and skin irritations.
Nanotechnology explores a variety of promising approaches in the area of material sciences on a molecular level, and silver nanoparticles (AgNPs) are of leading interest in the present scenario. This ...review is a comprehensive contribution in the field of green synthesis, characterization, and biological activities of AgNPs using different biological sources.
Biosynthesis of AgNPs can be accomplished by physical, chemical, and green synthesis; however, synthesis via biological precursors has shown remarkable outcomes. In available reported data, these entities are used as reducing agents where the synthesized NPs are characterized by ultraviolet-visible and Fourier-transform infrared spectra and X-ray diffraction, scanning electron microscopy, and transmission electron microscopy.
Modulation of metals to a nanoscale drastically changes their chemical, physical, and optical properties, and is exploited further via antibacterial, antifungal, anticancer, antioxidant, and cardioprotective activities. Results showed excellent growth inhibition of the microorganism.
Novel outcomes of green synthesis in the field of nanotechnology are appreciable where the synthesis and design of NPs have proven potential outcomes in diverse fields. The study of green synthesis can be extended to conduct the in silco and in vitro research to confirm these findings.
To evaluate the efficacy of dexamethasone as a final intracanal rinse in relieving postoperative pain of teeth with symptomatic irreversible pulpitis.
Randomised controlled trial. Place and Duration ...of the Study: Department of Operative Dentistry, PIMS, Islamabad, Pakistan, from June 2019 to December 2020.
Sixty patients aged 18- 50 years diagnosed with symptomatic irreversible pulpitis were selected according to the inclusion criterion. After obtaining informed consent, root canal therapy (RCT) was initiated under rubber dam. Pulpectomy was done followed by canal preparation. The lottery method was utilised for the division of patients. Group A (experimental) received dexamethasone (4mg/ml in 5ml syringe) as a final rinse, while Group B (control group) recalled after 1 week and asked whether their pain had relieved or not as a yes/no question. After data collection teeth were obturated and permanent restoration was placed. Data were analysed using Chi-square test.
The efficacy of dexamethasone as a final intracanal rinse was greater than saline 86.67% and 20.0%, respectively (p < 0.05) in relieving postoperative pain in teeth with symptomatic irreversible pulpitis.
Dexamethasone was proved to be more efficacious than saline in alleviating postoperative pain when used as a final intracanal rinse after canal instrumentation.
Irreversible pulpitis, Dexamethasone, Postoperative pain, Pulpectomy.
Objective: To compare the effects of motor control exercises, general exercises and spinal manipulative therapy on pain, functional status and disability in chronic low back pain patients. Study ...Design: Randomized Clinical Trial (IRCT:20200511047391N1) Place and Duration of Study: Riphah International University, Islamabad Pakistan, from Jun to Nov 2020. Methodology: Study was conducted on 36 chronic low back pain patients aged 18-50 years. All were randomly allocated to three groups: general exercises group, motor control group, and manipulative therapy; all were treated with eight sessions in four weeks. Numerical pain rating scale, Patient-specific functional scale and Oswestry disability index were used. Results: Findings revealed that differences between the three groups were statistically significant (p<0.05) concerning pain score, patient-specific functional scale, and Disability index. Conclusion: It was concluded that motor control exercises are most effective in treating chronic low backache. The results of our study showed that there is a significant difference in pain, function and disability in all the groups.
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