Por medio de un modelado de procesos de negocios, en general las organizaciones han logrado optimizar sus procesos a través de una arquitectura de procesos robusta y automatizada. De igual forma, a ...través de la gestión de riesgos las empresas buscan garantizar que se identifique, analice y responda adecuadamente a los riesgos que pueden afectar negativamente la realización de sus objetivos estratégicos. Con base en la evaluación de riesgos, una organización deberá elegir si acepta, mitiga o transfiere el riesgo a otro o al mismo proceso. Cuando se realiza de manera efectiva, la gestión de los riesgos en los procesos de negocio asegura que se prioricen los recursos limitados de la organización para abordar de la manera más eficiente los problemas que más les afectarán, y se logre de esa manera su continuidad y sostenibilidad. Este artículo explora preguntas asociadas a: ¿Cuáles son los riesgos que se asocian a los procesos de negocio? y ¿Cómo el uso del modelado BPM y la minería de procesos facilitan la gestión de los riesgos en todas las etapas del ciclo de vida de los procesos? Los aportes más importantes están relacionados con el mapeo de los riesgos del ciclo a un marco funcional y específico, y afectan el ciclo de vida en su totalidad, los cuales fueron analizados por medio de una minería de procesos.
This paper shows a study about nonattendance to medical appointments in the Colombian health system to determine which strategies have the greatest effect on the response variable (nonattendance) of ...scheduled medical appointments. Three factors were considered (calling the patient, reconfirming on the eve of the appointment, confirming understanding of the procedure), each with two or three levels randomly selected from a population. Two replicates were taken for each combination of treatments. The experimental runs were donerandomly to guarantee the absence of bias in data collection. With the above, a total of 180 experimental runs were carried out. This study aims to determine the factors that influence the population when they do not attend their medical appointments to propose a strategy that reduces this phenomenon. A design of experiments (DoE) was performed, specifically a completely randomized design (CRD) and a 3k factorial design
Introduction: This research is motivated, by the current world situation, caused by the pandemic declared by the WHO before the spread and severity of the coronavirus disease (COVID-19), notified for ...the first time in Wuhan (China) on December 31 of 2019. Through mathematical and statistical analysis, it seeks to show and explain in an expeditious manner, the causes for which there is a higher rate of contagion and lethality due to the virus, in different countries, taking into consideration patterns associated with social political behavior and economic, as a first approach to knowing statistics that allow generating forecasts for future periods, given the conditions.
Objective: The main objective of this work is to define the correlation of the economic, social and demographic variables of the countries of America, with respect to the contagion of the virus, proposing a forecast model on the level of contagion in each cluster proposed by the different regions of the American continent. Methodology: The study performs clustering (grouping) of the countries of America with respect to their geographical position North America, Central America and the Caribbean islands and South America, followed by a search for statistical data on social, economic and demographic indicators of the countries of America in recent years and statistics of levels of contagion of COVID 19 in sources such as international organizations regulating health issues. Next, a characterization and correlation of the collected data was carried out, to finally, based on the results of the correlation, make a forecast of the level of contagion that would be reached by each of the regions. Results: The purpose of this document is to provide information on the countries of North America, Latin America and the Caribbean with respect to the analysis of mortality from COVID-19, through methods of analysis of mortality from all causes as one of the approaches proposed to contribute to the assessment of the true magnitude of the burden of the COVID-19 epidemic in these countries.
Conclusions: The results show interesting information, since the Latin American curve turned out to be much less pronounced than that of the United States, in terms of contagion and deaths, despite the socio-demographic conditions, economic, technological and political opportunities. This analysis invites us to find out which are those correlations that directly impact the behavior of infections, taking into account variables such as age, gender, stratum, level of education, and other sociodemographic characteristics that may influence the spread or containment of the virus. Future research: It is proposed to study the correlation between race, sex, region and age vs levels of COVID 19 contagion in the Colombian context and the application of more robust statistical tools to develop models that allow correlation of variables and define possible level scenarios contagion, in addition to conducting a correlation study of economic and socio-demographic variables with respect to other diseases such as zika and dengue
Through process management (BPM) organizations have managed to optimize their processes through a robust and automated process architecture. Similarly, through risk management, companies seek to ...ensure that risks that may negatively affect the achievement of their strategic objectives are identified, analyzed, and adequately responded to. Based on the risk assessment, an organization will need to choose whether to accept, mitigate, or transfer the risk to another or to the same process. When done effectively, risk management in business processes ensures that the organization's limited resources are prioritized to most efficiently address the issues that will most affect them, thus achieving their continuity and sustainability. This article explores questions associated with: What are the risks associated with business processes? And how can risk management be integrated into the BPM business process management stages? The most important contributions are related to the mapping of risks during the BPM life cycle, the description of existing methodologies for the independent analysis of risks and business processes, and the discovery of a knowledge gap in the face of a methodology that integrate them.
All metazoans depend on the consumption of O
by the mitochondrial oxidative phosphorylation system (OXPHOS) to produce energy. In addition, the OXPHOS uses O
to produce reactive oxygen species that ...can drive cell adaptations
, a phenomenon that occurs in hypoxia
and whose precise mechanism remains unknown. Ca
is the best known ion that acts as a second messenger
, yet the role ascribed to Na
is to serve as a mere mediator of membrane potential
. Here we show that Na
acts as a second messenger that regulates OXPHOS function and the production of reactive oxygen species by modulating the fluidity of the inner mitochondrial membrane. A conformational shift in mitochondrial complex I during acute hypoxia
drives acidification of the matrix and the release of free Ca
from calcium phosphate (CaP) precipitates. The concomitant activation of the mitochondrial Na
/Ca
exchanger promotes the import of Na
into the matrix. Na
interacts with phospholipids, reducing inner mitochondrial membrane fluidity and the mobility of free ubiquinone between complex II and complex III, but not inside supercomplexes. As a consequence, superoxide is produced at complex III. The inhibition of Na
import through the Na
/Ca
exchanger is sufficient to block this pathway, preventing adaptation to hypoxia. These results reveal that Na
controls OXPHOS function and redox signalling through an unexpected interaction with phospholipids, with profound consequences for cellular metabolism.
GEIDIS is a national-based research-net registry of patients with bronchopulmonary dysplasia (BPD) from public and private Spanish hospitals. It was created to provide data on the clinical ...characterization and follow-up of infants with BPD until adulthood. The purpose of this observational study was to analyze the characteristics and the impact of perinatal risk factors on BPD severity. The study included 1755 preterm patients diagnosed with BPD. Of the total sample, 90.6% (
n
= 1591) were less than 30 weeks of gestation. The median gestational age was 27.1 weeks (25.8–28.5) and median birth weight 885 g (740–1,070 g). A total of 52.5% (
n
= 922) were classified as mild (type 1), 25.3% (
n
= 444) were moderate (type 2), and 22.2% (
n
= 389) were severe BPD (type 3). In patients born at under 30 weeks’ gestation, most pre-and postnatal risk factors for type 2/3 BPD were associated with the length of exposure to mechanical ventilation (MV). Independent prenatal risk factors were male gender, oligohydramnios, and intrauterine growth restriction. Postnatal risk factors included the need for FiO
2
of > 0.30 in the delivery room, nosocomial pneumonia, and the length of exposure to MV.
Conclusion
: In this national-based research-net registry of BPD patients, the length of MV is the most important risk factor associated with type 2/3 BPD. Among type 3 BPD patients, those who required an FiO
2
> .30 at 36 weeks’ postmenstrual age had a higher morbidity, during hospitalization and at discharge, compared to those with nasal positive pressure but FiO
2
< .30.
What is Known:
• BPD is a highly complex multifactorial disease associated with preterm birth.
What is New:
• The length of exposure to mechanical ventilation is the most important postnatal risk factor associated to bronchopulmonary severity which modulate the effect of most pre and postnatal risk factors.
• Among patients with BPD, the requirement for FiO2 >.30% at 36 weeks of postmenstrual age is associated with greater morbidity during hospitalization and at discharge.
INTRODUCTIONThe aim of this study was to know, through a national survey, the methods and techniques used for the diagnosis of Helicobacter pylori (Hp) in the different Clinical Microbiology ...Services/Laboratories in Spain, as well as antibiotic resistance data. METHODSThe survey requested information about the diagnostic methods performed for Hp detection in Clinical Microbiology laboratories, including serology, stool antigen, culture from gastric biopsies, and PCR. In addition, the performance of antibiotic susceptibility was collected. Data on the number of samples processed in 2016, positivity of each technique and resistance data were requested. The survey was sent by email (October-December 2017) to the heads of 198 Clinical Microbiology Laboratories in Spain. RESULTSOverall, 51 centers from 29 regions answered the survey and 48/51 provided Hp microbiological diagnostic testing. Concerning the microbiological methods used to diagnose Hp infection, the culture of gastric biopsies was the most frequent (37/48), followed by stool antigen detection (35/48), serology (19/48) and biopsy PCR (5/48). Regarding antibiotic resistance, high resistance rates were observed, especially in metronidazole and clarithromycin (over 33%). CONCLUSIONCulture of gastric biopsies was the most frequent method for detection of Hp, but the immunochromatographic stool antigen test was the one with which the largest number of samples were analyzed. Nowadays, in Spain, it concerns the problem of increased antibiotic resistance to 'first-line' antibiotics.
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