Macromolecules with aggregation-induced emission (AIE) attributes are a class of luminescent materials that display enhanced emission when they are aggregated. They have attracted much attention ...because of their good solubility, processability, high emission efficiency in the aggregated states, etc. A large variety of AIE macromolecules have been developed, showing exponential growth of research interest in this field. This review summarizes the design principles and recent synthetic advancements, topological structures, as well as the frontiers of functionalities and potential applications of AIE macromolecules, especially fluorescence sensing, biological applications and optoelectronic applications, with an emphasis on the recent progress. New luminogenic systems without conventional chromophores displaying aggregated state emission are discussed. The highly dense clusters of heteroatoms with lone pair electrons in these systems may serve as the chromophore and are cited as "heterodox clusters". It is expected that the mechanistic insights into the AIE phenomena, based on the restriction of intramolecular motions and structure rigidification, can guide the future design of AIE materials with fascinating structures and functionalities.
Although better insights into the natural course of cystic fibrosis (CF) have led to treatment approaches that have improved pulmonary health and increased the life expectancy of individuals with ...this disorder, lung disease remains the main cause of morbidity and mortality in patients with CF. Evidence suggests that airway epithelial defects in ions-water transport lead to dehydrated mucus, impaired mucus clearance, and mucus adhesion to airway surfaces. An increase in mucin secretion is also suggested by the formation of endobronchial mucus plaques and plugs, which become the main sites of air flow obstruction, infection, and inflammation conducing to early small airways disease followed by the development of bronchiectasis. The lung involvement is usually progressive with intermittent exacerbations. Aggressive management and advances in treatment delay, but, do not prevent progression of lung disease. Respiratory failure ensues and is the major cause of death. The lung parenchyma is virtually untouched for much of the course of the disease. This review focuses on the lung involvement in cystic fibrosis and summarizes new developments on the diagnostic approach of CF and pathogenesis of related lung disease. Current therapeutic modalities, novel therapies targeting the basic genetic defect, and lung transplantation are also reviewed.
" King and Emperor takes on the compelling suspense of good detective work as well as good history."— The Wall Street Journal Charles I, often known as Charlemagne, is one of the most extraordinary ...figures ever to rule an empire. Driven by unremitting physical energy and intellectual curiosity, he was a man of many parts, a warlord and conqueror, a judge who promised "for each their law and justice, " a defender of the Latin Church, a man of flesh and blood. In the twelve centuries since his death, warfare, accident, vermin, and the elements have destroyed much of the writing on his rule, but a remarkable amount has survived. Janet Nelson's wonderful new book brings together everything we know about Charles I, sifting through the available evidence, literary and material, to paint a vivid portrait of the man and his motives. Building on Nelson's own extraordinary knowledge, this biography is a sort of detective story, prying into and interpreting fascinating and often obdurate scraps of evidence, from prayer books to skeletons, gossip to artwork. Charles's legacy lies in his deeds and their continuing resonance, as he shaped counties, countries, and continents; founded and rebuilt towns and monasteries; and consciously set himself up not just as King of the Franks, but as the head of the renewed Roman Empire. His successors—even to the present day—have struggled to interpret, misinterpret, copy, or subvert his legacy. Janet Nelson gets us as close as we can hope to come to the real figure of Charles the man as he was understood in his own time.
The coordinated operation of distributed energy resources such as storage and generation units and also loads is required for the reliable operation of an islanded microgrid. Since in islanded ...microgrids the storage units are commonly responsible for regulating the voltage amplitude and frequency in the local power system, the coordination should consider safe operating limits for the stored energy, which prevents fast degradation or damage to the storage units. This paper proposes a centralized control architecture, applicable for local area power systems such as a small-scale microgrid. The centralized architecture is based on three supervisory control tasks which consider: active power curtailment of generation for avoiding overcharge of the storage units, load shedding actions for preventing deep discharge of the storage units, and equalization of the state of charge (SoC) among distributed storage systems for avoiding uneven degradation. The proposed equalization method has proved to be effective for equalizing the SoC of distributed energy storage systems and for ensuring uniform charge/discharge ratios regardless of differences in the capacity of the storage units. Additionally, the strategy is complemented with an optimal scheduling of load connection, which minimizes the connection and disconnection cycles of the loads within a time horizon of 24 h. The proposed architecture is verified experimentally in a lab-scale prototype of a microgrid, which has real communication between the microgrid and the central controller.
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) uses the Sequential Organ Failure Assessment (SOFA) score to grade organ dysfunction in adult patients with ...suspected infection. However, the SOFA score is not adjusted for age and therefore not suitable for children.
To adapt and validate a pediatric version of the SOFA score (pSOFA) in critically ill children and to evaluate the Sepsis-3 definitions in patients with confirmed or suspected infection.
This retrospective observational cohort study included all critically ill children 21 years or younger admitted to a 20-bed, multidisciplinary, tertiary pediatric intensive care unit between January 1, 2009 and August 1, 2016. Data on these children were obtained from an electronic health record database. The pSOFA score was developed by adapting the original SOFA score with age-adjusted cutoffs for the cardiovascular and renal systems and by expanding the respiratory criteria to include noninvasive surrogates of lung injury. Daily pSOFA scores were calculated from admission until day 28 of hospitalization, discharge, or death (whichever came first). Three additional pediatric organ dysfunction scores were calculated for comparison.
Organ dysfunction measured by the pSOFA score, and sepsis and septic shock according to the Sepsis-3 definitions.
The primary outcome was in-hospital mortality. The daily pSOFA scores and additional pediatric organ dysfunction scores were compared. Performance was evaluated using the area under the curve. The pSOFA score was then used to assess the Sepsis-3 definitions in the subgroup of children with confirmed or suspected infection.
In all, 6303 patients with 8711 encounters met inclusion criteria. Each encounter was treated independently. Of the 8482 survivors of hospital encounters, 4644 (54.7%) were male and the median (interquartile range IQR) age was 69 (17-156) months. Among the 229 nonsurvivors, 127 (55.4%) were male with a median (IQR) age of 43 (8-144) months. In-hospital mortality was 2.6%. The maximum pSOFA score had excellent discrimination for in-hospital mortality, with an area under the curve of 0.94 (95% CI, 0.92-0.95). The pSOFA score had a similar or better performance than other pediatric organ dysfunction scores. According to the Sepsis-3 definitions, 1231 patients (14.1%) were classified as having sepsis and had a mortality rate of 12.1%, and 347 (4.0%) had septic shock and a mortality rate of 32.3%. Patients with sepsis were more likely to die than patients with confirmed or suspected infection but no sepsis (odds ratio, 18; 95% CI, 11-28). Of the 229 patients who died during their hospitalization, 149 (65.0%) had sepsis or septic shock during their course.
The pSOFA score was adapted and validated with age-adjusted variables in critically ill children. Using the pSOFA score, the Sepsis-3 definitions were assessed in children with confirmed or suspected infection. This study is the first assessment, to date, of the Sepsis-3 definitions in critically ill children. Use of these definitions in children is feasible and shows promising results.
Aggregation‐induced emission (AIE) has been harnessed in many systems through the principle of restriction of intramolecular rotations (RIR) based on mechanistic understanding from archetypal AIE ...molecules such as tetraphenylethene (TPE). However, as the family of AIE‐active molecules grows, the RIR model cannot fully explain some AIE phenomena. Here, we report a broadening of the AIE mechanism through analysis of 10,10′,11,11′‐tetrahydro‐5,5′‐bidibenzoa,d7annulenylidene (THBDBA), and 5,5′‐bidibenzoa,d7annulenylidene (BDBA). Analyses of the computational QM/MM model reveal that the novel mechanism behind the AIE of THBDBA and BDBA is the restriction of intramolecular vibration (RIV). A more generalized mechanistic understanding of AIE results by combining RIR and RIV into the principle of restriction of intramolecular motions (RIM).
Luminescence turn‐on: Through theoretical calculations to explain empirical observation, it is now possible to more fully explain the phenomenon of aggregation‐induced emission. By comparing tetraphenylethene and its structurally similar analogues, deeper insight has been gained into this photophysical phenomenon in which luminescence can be turned on in the aggregated or solid state.
Optical communication technology has been advancing rapidly for several decades, supporting our increasingly information-driven society and economy. Much of this progress has been in finding ...innovative ways to increase the data-carrying capacity of a single optical fibre. To achieve this, researchers have explored and attempted to optimize multiplexing in time, wavelength, polarization and phase. Commercial systems now utilize all four dimensions to send more information through a single fibre than ever before. The spatial dimension has, however, remained untapped in single fibres, despite it being possible to manufacture fibres supporting hundreds of spatial modes or containing multiple cores, which could be exploited as parallel channels for independent signals.
The digitalization of the health-care system has resulted in a deluge of clinical big data and has prompted the rapid growth of data science in medicine. Data science, which is the field of study ...dedicated to the principled extraction of knowledge from complex data, is particularly relevant in the critical care setting. The availability of large amounts of data in the ICU, the need for better evidence-based care, and the complexity of critical illness makes the use of data science techniques and data-driven research particularly appealing to intensivists. Despite the increasing number of studies and publications in the field, thus far there have been few examples of data science projects that have resulted in successful implementations of data-driven systems in the ICU. However, given the expected growth in the field, intensivists should be familiar with the opportunities and challenges of big data and data science. The present article reviews the definitions, types of algorithms, applications, challenges, and future of big data and data science in critical care.
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