Molecular hydrogen ions in weakly bound states close to the first dissociation threshold are attractive quantum sensors for measuring the proton-to-electron mass ratio and hyperfine-induced ...ortho-para mixing. The experimental accuracy of previous spectroscopic studies relying on fast ion beams could be improved by using state-of-the-art ion trap setups. With the electric-dipole moment vanishing in H
and preventing fast spontaneous emission, radiative lifetimes of the order of weeks are found. We include the effect of black-body radiation that can lead to photodissociation and rovibronic state redistribution to obtain effective lifetimes for trapped ion experiments. Rate coefficients for bound-bound and bound-continuum processes were calculated using adiabatic nuclear wave functions and nonadiabatic energies, including relativistic and radiative corrections. Effective lifetimes for the weakly bound states were obtained by solving a rate equation model and lifetimes in the range of 4-523 and >215 ms were found at room temperature and liquid nitrogen temperature, respectively. Black-body induced photodissociation was identified as the lifetime-limiting effect, which guarantees the purity of state-selectively generated molecular ion ensembles. The role of hyperfine-induced g/u-mixing, which allows pure rovibrational transitions, was found to be negligible.
We present the calculation of the light neutral CP-even Higgs mass in the MSSM for a heavy SUSY spectrum by resumming enhanced terms through fourth logarithmic order (N
3
LL), keeping terms of ...leading order in the top Yukawa coupling
α
t
, and NNLO in the strong coupling
α
s
. To this goal, the three-loop matching coefficient for the quartic Higgs coupling of the SM to the MSSM is derived to order
α
t
2
α
s
2
by comparing the perturbative EFT to the fixed-order expression for the Higgs mass. The new matching coefficient is made available through an updated version of the program Himalaya. Numerical effects of the higher-order resummation are studied using specific examples, and sources of theoretical uncertainty on this result are discussed.
Background The occlusion of the artery of Percheron results in bilateral thalamic and mesencephalic infarctions. In this series, we attempted to classify the subtypes of clinical presentations and ...long-term prognosis with regards to radiological patterns. Methods We sought the clinical and radiological findings of 15 (8 men and 7 women; mean age 48 years) consecutive patients with Percheron artery infarct over 10 years. We classified the clinical symptoms according to the presence of a mental status disturbance (MSD), behavioral amnesic impairment (BAI), aphasia/dysarthria, ocular movement disorders (OMDs), motor deficit, cerebellar signs, and others. The Percheron artery infarct images were classified as bilateral paramedian thalamic with rostral midbrain infarction (BPTRMI), bilateral paramedian thalamic without midbrain infarction (BPTWMI), bilateral paramedian and anterior thalamic with midbrain infarction (BPATMI), and bilateral paramedian and anterior thalamic without midbrain infarction. The outcome was evaluated using a modified Rankin Scale (mRS). Results OMD and MSD were the most common clinical manifestations in patients with BPTRMI (n = 8). BAI and MSD were the main clinical findings in patients with BPTWMI (n = 6). A patient with BPATMI had a combination of clinical manifestations. After a mean follow-up of 55 months, a good outcome (mRS score ≤ 2) was present in 25% of the patients with BPTRMI, 67% of the patients with BPTWMI, and in 1 patient with BPATMI. Conclusions Our findings suggest that it is possible to identify clinical and radiological subgroups of Percheron artery infarct. The long-term follow-up outcome is generally good, except in cases with midbrain involvement.
We used 5 diagnostic tests in a cross-sectional investigation of the prevalence of Trypanosoma cruzi in Tejupilco municipality, State of Mexico, Mexico. Our findings showed a substantial prevalence ...of immunoglobulin G (IgG) and IgM antibodies to T. cruzi in human (n = 293, IgG 2.05%, IgM 5.5%, both 7.1%) and dog (n = 114, IgG 15.8%, IgM 11.4%, both 21%) populations. We also found antibodies to T. cruzi (n = 80, IgG 10%, IgM 15%, both 17.5%) in dogs from Toluca, an area previously considered free of T. cruzi. Our data demonstrate the need for active epidemiologic surveillance programs in these regions. A direct correlation (r2 = 0.955) of seropositivity between humans and dogs suggests that seroanalysis in dogs may help identify the human prevalence of T. cruzi infection in these areas.
Blood pressure is not a static parameter, but rather undergoes continuous fluctuations over time, as a result of the interaction between environmental and behavioural factors on one side and ...intrinsic cardiovascular regulatory mechanisms on the other side. Increased blood pressure variability (BPV) may indicate an impaired cardiovascular regulation and may represent a cardiovascular risk factor itself, having been associated with increased all-cause and cardiovascular mortality, stroke, coronary artery disease, heart failure, end-stage renal disease, and dementia incidence. Nonetheless, BPV was considered only a research issue in previous hypertension management guidelines, because the available evidence on its clinical relevance presents several gaps and is based on heterogeneous studies with limited standardization of methods for BPV assessment. The aim of this position paper, with contributions from members of the European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability and from a number of international experts, is to summarize the available evidence in the field of BPV assessment methodology and clinical applications and to provide practical indications on how to measure and interpret BPV in research and clinical settings based on currently available data. Pending issues and clinical and methodological recommendations supported by available evidence are also reported. The information provided by this paper should contribute to a better standardization of future studies on BPV, but should also provide clinicians with some indications on how BPV can be managed based on currently available data.
Molecular hydrogen ions in weakly bound states close to the first
dissociation threshold are attractive quantum sensors for measuring the
proton-to-electron mass ratio and hyperfine-induced ...ortho-para mixing. The
experimental accuracy of previous spectroscopic studies relying on fast ion
beams could be improved by using state-of-the-art ion trap setups. With the
electric dipole moment vanishing in H$_2^+$ and preventing fast spontaneous
emission, radiative lifetimes of the order of weeks are found. We include the
effect of black-body radiation that can lead to photodissociation and
rovibronic state redistribution to obtain effective lifetimes for trapped ion
experiments. Rate coefficients for bound-bound and bound-continuum processes
were calculated using adiabatic nuclear wave functions and nonadiabatic
energies, including relativistic and radiative corrections. Effective lifetimes
for the weakly bound states were obtained by solving a rate equation model and
lifetimes in the range of 4 to 523~ms and $>$215~ms were found at room
temperature and liquid nitrogen temperature, respectively. Black-body induced
photodissociation was identified as the lifetime-limiting effect, which
guarantees the purity of state-selectively generated molecular ion ensembles.
The role of hyperfine-induced $g/u$-mixing, which allows pure rovibrational
transitions, was found to be negligible.
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•A stereoselective synthesis of 26-Linezolid dipeptide-type analogous was performed.•Docking analysis shows the coupling of Linezolid dipeptide-type analogues in PTC.•Linezolid ...analogues display antibacterial activity against clinical isolates.•Linezolid dipeptide-type analogous preserve the cellular integrity of ARPE-19 cells.
Worldwide studies towards development of new drugs with a lower rate in emergence of bacterial resistance have been conducted. The molecular docking analysis gives a possibility to predict the activity of new compounds before to perform their synthesis. In this work, the molecular docking analysis of 64 Linezolid dipeptide-type analogues was performed to predict their activity. The most negative scores correspond to six Fmoc-protected analogues (9as, 9bs, 9bu, 10as, 10ax and 10ay) where Fmoc group interacts in PTC for Linezolid. Twenty-six different Fmoc-protected Linezolid dipeptide-type analogues 9(as-bz) and 10(as-bz) were synthesized and tested in antimicrobial experiments. Compounds 9as, 9ay, 9ax, 10as, 10ay and 9bu show significant activity against group A Streptococcus clinical isolated. Analogue 10ay also display high activity against ATCC 25923 Staphylococcus aureus strain and MRSA-3, MRSA-4 and MRSA-5 clinical isolates, with MIC values lower than Linezolid. The highest activity against multidrug-resistant clinical isolates of Mycobacterium tuberculosis was exhibited by 9bu. Finally, a cytotoxicity assay with ARPE-19 human cells revealed a non-cytotoxic effect of 9bu and 10ay at 50 and 25 μM, respectively.
El Internet se ha convertido en la plataforma definitiva para la convergencia, estrechamente asociada con las redes, la tecnología y los medios, debido a su arquitectura abierta y no discriminatoria. ...La convergencia en las telecomunicaciones es impulsada por ideas, ideologías y políticas de manera progresiva y cíclica, lo que genera más avances tecnológicos, cambios en el mercado, los negocios y las políticas. Como respuesta a la convergencia, la neutralidad en la red busca regular la relación entre los proveedores de servicios de Internet y los usuarios para evitar prácticas discriminatorias y asegurar un Internet abierto como plataforma de innovación, desarrollo económico y acceso a la información para todos. El objetivo de este trabajo es analizar el desarrollo de la convergencia en el sector de las telecomunicaciones y el avance de las políticas de neutralidad en la red en América del Sur, con cinco casos específicos utilizando un enfoque empírico cualitativo. Dentro de los hallazgos, se identifican diferentes enfoques para legislar la neutralidad en la red, controversias sobre los niveles de compromiso con los principios, ambigüedad para la aplicación efectiva de las reglas y acuerdos comerciales que en la práctica violan la neutralidad de la red.
ABSTRACT
Background
Sodium–glucose cotransporter-2 inhibitors (SGLT2is) have cardioprotective and renoprotective effects. However, experience with SGLT2is in diabetic kidney transplant recipients ...(DKTRs) is limited.
Methods
This observational multicentre study was designed to examine the efficacy and safety of SGLT2is in DKTRs. The primary outcome was adverse effects within 6 months of SGLT2i treatment.
Results
Among 339 treated DKTRs, adverse effects were recorded in 26%, the most frequent (14%) being urinary tract infection (UTI). In 10%, SGLT2is were suspended mostly because of UTI. Risk factors for developing a UTI were a prior episode of UTI in the 6 months leading up to SGLT2i use {odds ratio OR 7.90 confidence interval (CI) 3.63–17.21} and female sex OR 2.46 (CI 1.19–5.03). In a post hoc subgroup analysis, the incidence of UTI emerged as similar in DKTRs treated with SGLT2i for 12 months versus non-DKTRs (17.9% versus 16.7%). Between baseline and 6 months, significant reductions were observed in body weight −2.22 kg (95% CI −2.79 to −1.65), blood pressure, fasting glycaemia, haemoglobin A1c −0.36% (95% CI −0.51 to −0.21), serum uric acid −0.44 mg/dl (95% CI −0.60 to −0.28) and urinary protein:creatinine ratio, while serum magnesium +0.15 mg/dl (95% CI 0.11–0.18) and haemoglobin levels rose +0.44 g/dl (95% CI 0.28–0.58. These outcomes persisted in participants followed over 12 months of treatment.
Conclusions
SGLT2is in kidney transplant offer benefits in terms of controlling glycaemia, weight, blood pressure, anaemia, proteinuria and serum uric acid and magnesium. UTI was the most frequent adverse effect. According to our findings, these agents should be prescribed with caution in female DKTRs and those with a history of UTI.
Lay Summary
Experience with sodium–glucose cotransporter-2 inhibitor (SGLT2i) treatment in diabetic kidney transplant recipients (DKTRs) is limited, as these agents may increase the risk of kidney graft dysfunction and urinary tract infection (UTI). Recently, however, these drugs have shown clear nephroprotective and cardioprotective effects in non-transplanted individuals with diabetes. The objective of this multicentre study was to describe our experience with SGLT2i treatment in DKTRs.
Treatment was effective in controlling glycemia and had the additional benefits of improving weight, blood pressure, anaemia, proteinuria and serum levels of magnesium and uric acid. However, the frequency of UTI was greater than that reported for non-transplanted diabetic individuals. Previous UTIs and female sex were identified as risk factors for developing a UTI.
The findings of this study suggest that as with non-transplanted diabetics, DKTRs will benefit from SGLT2i treatment, although female patients and those with a history of UTI need to be closely monitored.
Graphical Abstract
Graphical Abstract
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