INTRODUCTIONSuicide is a serious public health problem that affects the whole world. This study describes development of the prototype for an mHealth application (app) intended to assist healthcare ...professionals to identify suicide risk in hospitalized patients and reports on testing of the app by some of these professionals, conducted to confirm its functionality. METHODThis is applied exploratory research into use of Information Technology within the healthcare field, based on application prototyping for mobile devices. The research was conducted at the Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA) from 2017 to 2019. Six healthcare professionals, one data scientist, and three undergraduate students in Biomedical Informatics took part in the study. All research participants signed the free and informed consent form. RESULTSThe main findings show that the development team created a prototype named Detect-S, which became a cross-platform application (iOS and Android) offering 16 functions. CONCLUSIONIt can be concluded that Detect-S has the potential to be a positive technological instrument that can be tested in a hospital setting to assist healthcare professionals to identify and manage patients with at risk of suicide.
The crop intercropping is a viable option for family farmers who grow in small spaces and need to take advantage of all the available area. The objective of this study was to evaluate the agronomic ...viability of the intercropping of beet with salad rocket (arugula) under different amounts of Merremia aegyptia plus goat manure. The experiment was conducted at Rafael Fernandes Experimental Farm, in the Alagoinha district, rural area of Mossoro-RN, from August to December 2016. The experimental design was a randomized complete block with treatments arranged in a 2 x 4 factorial scheme, with three repetitions. The first factor was the single beet and second intercropped cultivation of beet and arugula. The second factor was the amount of Merremia aegyptia plus goat manure (0.0, 1.5, 3.0 and 4.5 kg m-2). For the sugar beet crop the following characteristics were evaluated: plant height, fresh leaf mass, commercial root yield and root dry mass. For arugula culture the following characteristics were evaluated: plant height, number of leaves per plant, yield, number of sauces and dry mass. The best agronomic performance of the beet and rocket intercropping was obtained in the amount of 4.5 kg m-2 of M. aegyptia beds and goat manure. The consortium presented an area ratio equivalent to over 1.0, with an average value of 1.81 in the amount of 4.5 kg m-2 of M. aegyptia flowerbed plus goat manure. The consortium contributed to better use of available resources without compromising the commercial quality of the vegetables.
The structural fragility of monoclonal antibodies (mAbs), such as bevacizumab (BVZ), is a critical parameter for oral administration and can limit the use of several technologies to produce oral ...nanocarriers for these biomolecules. Nanoparticles (NPs) based on gellan gum (GG) and retrograded starch (RS) were rationally designed through polyelectrolyte complexation, and ionic cross-linking was exploited as an additional technological strategy to modulate the properties of nanocarriers. According to static light scattering analysis, the molecular weights of GG and RS were approximately 158 kDa and 1803 kDa, respectively. The influence of pH on the zeta potential (ZP) of polymers allowed the selection of pH 6.2 as the most suitable pH for the complexation of these polyelectrolytes. Non-cross-linked NPs were prepared at different polymer:drug ratios and the effects of formulation variables (polyelectrolyte ratio, drug and cross-linker concentrations, and polymer:drug ratio) on the formation and properties (size, ZP, and PDI) of cross-linked NPs were evaluated using a 33 full-factorial design. The average size of non-cross-linked and cross-linked NPs ranged from 260.1 - 299.6 nm to 265.7–629.9 nm, respectively. NPs-negative ZP (>- 20 mV) and high association efficiency (AE%) (>56.16%) were achieved. Cross-linking significantly increased the BVZ AE% (85%–100%). Analyses by attenuated total reflectance-Fourier transform infrared, fluorescence, circular dichroism, and differential scanning microcalorimetry techniques demonstrated that polyelectrolyte complexation and ionic cross-linking did not denature the secondary and tertiary structures of BVZ. The results revealed the suitability of the technological approaches used to produce BVZ-loaded nanocarriers with tailored properties, representing a potential platform for the oral delivery of BVZ.
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RESUMEN INTRODUCCIÓN Algunos estudios apuntan a una asociación entre la evolución de la prevalencia de enfermedades crónicas no transmisibles con los patrones alimentarios y la situación nutricional ...de la población. El objetivo de este estudio fue describir el consumo de frutas y verduras en Argentina y su asociación con factores socioeconómicos, demográficos y de actividad física, a nivel individual, provincial y regional. MÉTODOS Se utilizó un modelo multinivel, con información de la Encuesta Nacional de Factores de Riesgo (2013) y del Censo Nacional (2001 y 2010). RESULTADOS El modelo demostró que ser del sexo femenino, tener más años de edad, ingreso a partir de 4.501 pesos y nivel de instrucción secundario completo o más se asocia de manera positiva al consumo de estos alimentos. En contraste, estar separado/a, divorciado/a, viudo/a o soltero/a y practicar actividad física moderada o baja se asocia negativamente a la ingesta de frutas y verduras. El efecto de la variabilidad explicada a nivel provincial y regional resultó ser mínimo. CONCLUSIONES El trabajo se enmarca en una línea de estudios que señalan que los factores relacionados con la alimentación saludable están vinculados a los entornos sociales y físicos, principalmente a características socioeconómicas del grupo de pertenencia y al contexto en que se vive. En este sentido, sería importante contar con información con mayores niveles de desagregación.
To assess the prevalence of vitamin D deficiency and factors associated with serum vitamin D levels in adult women with class II/III obesity.
We analysed baseline data from 128 adult women with class ...II/III obesity i.e. BMI ≥35 kg/m2 who participated in the DieTBra clinical trial. Sociodemographic, lifestyle, sun exposure, sunscreen, dietary intake of calcium and vitamin D, menopause, diseases, medication, and body composition data were analysed using multiple linear regression.
128 women had mean BMI 45.53 ± 6.36, mean age 39.7 ± 8.75 kg/m2 and serum vitamin D 30.02 ng/ml ± 9.80. Vitamin D deficiency was 14.01%. There was no association between serum vitamin D levels and BMI, body fat percentage, total body fat and waist circumference. Age group (p = 0.004), sun exposure/day (p = 0.072), use of sunscreen (p = 0.168), inadequate calcium intake (p = 0.030), BMI (p = 0.192), menopause (p = 0.029) and lipid-lowering drugs (p = 0.150) were included in the multiple linear regression. The following remained associated with low serum vitamin D: being 40–49 years (p = 0.003); ≥50 years of age (p = 0.020) and inadequate calcium intake (p = 0.027).
The prevalence of vitamin D deficiency was lower than expected. Lifestyle, sun exposure and body composition were not associated. Age over 40 years and inadequate calcium intake were significantly associated with low serum vitamin D levels.
Objetivo em meio à maior crise sanitária da história, deflagrada pela pandemia de COVID-19, o objetivo deste estudo documental foi compreender os sentidos atribuídos ao fenômeno da supressão de ...rituais fúnebres por pessoas que amargaram perdas de entes queridos, nesse contexto. Método com amparo da teoria do luto, foi constituído o corpus de pesquisa a partir de documentos publicados na mídia digital, contendo escritos pessoais e relatos de experiências abertos ao público. A análise temática indutiva dos textos foi realizada por dois pesquisadores com expertise. Resultados a experiência compartilhada nos depoimentos repercute o padecimento pela morte repentina de pessoa significativa, ampliado pela ausência ou truncamento de rituais familiares de despedida após o óbito. A supressão ou abreviação de rituais fúnebres é vivida como uma experiência traumática, pois familiares se veem impedidos de cumprirem suas últimas homenagens ao ente que se foi subitamente, gerando sentimentos de incredulidade e indignação. Conclusão é preciso criar alternativas e reinventar maneiras de celebrar os rituais de passagem em situações emergenciais de forte comoção social como uma pandemia, de modo a oferecer amparo e conforto aos familiares, amigos e parentes. Isso auxilia os sobreviventes a superarem o momento crítico, reduzindo o risco de desenvolvimento do luto complicado. Infecções por Coronavírus; Vírus da SARS; Pandemias; Luto; Saúde Mental; Rituais Fúnebres
Objetivo en medio a la mayor crisis sanitaria de la historia, deflagrada por la pandemia de COVID-19, este estudio documental tuvo por objetivo comprender los sentidos atribuidos al fenómeno de la ...supresión de rituales fúnebres por personas que sufrieron pérdidas de seres queridos en ese contexto. Método amparado en la teoría del luto, fue constituido el corpus de investigación a partir de documentos publicados en los medios de comunicación digital, conteniendo escritos personales y relatos de experiencias abiertas al público. El análisis temático inductivo de los textos fue realizado por dos investigadores con pericia. Resultados la experiencia compartida en las declaraciones repercute el padecimiento por la muerte repentina de persona significativa, ampliado por la ausencia o truncamiento de rituales familiares de despedida después de la muerte. La supresión o abreviación de rituales fúnebres es vivida como una experiencia traumática, ya que los familiares se encuentran impedidos de cumplir las últimas homenajes al ser que se fue súbitamente, generando sentimientos de incredulidad e indignación. Conclusión es necesario crear alternativas y reinventar maneras de celebrar los rituales de pasaje en situaciones de emergencia de fuerte conmoción social como una pandemia, de modo a ofrecer amparo y confort a los familiares, amigos y parientes. Esto auxilia a los supervivientes a superar el momento crítico, reduciendo el riesgo de desarrollar un luto complicado. Infecciones por Coronavirus; Virus del SRAS, Pandemias; Aflicción; Salud Mental; Ritos Fúnebres
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