The concurrence of a reciprocal translocation and an aneuploidy represent a rare coincidence and an interchromosome effect between these two events has been suggested. We report the case of a family ...with a t(1;15) in three generations which was identified through the evaluation ofa patient with classical trisomy 21 or Down syndrome. The cytogenetic analysis with GTG banding showed that the proband had a regular trisomy 21 and a balanced translocation t(1;15). FISH and microsatellite analysis were carried out in the family in order to discard an interchromosomal effect. The implications for genetic assessment are discussed.
In this work the turbulent flow of the Non-Newtonian Carreau-Yasuda fluid will be studied. A skin friction equation for the turbulent flow of Carreau-Yasuda fluids will be derived assuming a ...logarithmic behavior of the turbulent mean velocity for the near wall flow out of the viscous sub layer. An alternative near wall characteristic length scale which takes into account the effects of the relaxation time will be introduced. The characteristic length will be obtained through the analysis of viscous region near the wall. The results compared with experimental data obtained with Tylose (methyl hydroxil cellulose) solutions showing good agreement. The relations between scales integral and dissipative obtained for length, time, velocity, kinetic energy, and vorticity will be derived for this type of fluid. When the power law index approach to unity the relations reduces to newtonian case.
The aim of this study was to analyze the contents of referral letters related to clinical history and reason for consultation. A total of 236 consecutive referral letters were evaluated. Analysis of ...the referral letters was based on key items concerning patient identification, chief complaint, previous consultation, laboratory investigation and use of drugs for the chief complaint. A database was organized (Epinfo 6.04) and the χ2test (α=0.05) was applied to the results. Of the 800 files examined, only 30% (236) had a referral letter. Of the 236 referral letters, 67% were from dentists, 22% from physicians and 11% from unidentified professionals. Patient age did not appear in 70% of the letters and the chief complaint was mentioned only in 55%. The letters had no details such as description of the oral lesion (80%), anatomical site (34%), size (99%), symptoms (83%), or period of evolution (92%). Clinical diagnosis was not included in 84% of the letters. Less than 5% of the referral letters contained information about previous consultation and laboratory investigation. The χ2test showed significant differences for all items of the referral letter. Referral letters did not satisfy minimal requirements about clinical history or reason for consultation, leading to failed communication among professionals. Based on this study, we suggest that standard letters are important to improve the quality of the letters, reducing the rate of omission of relevant items.
OBJECTIVE: To evaluate the discrepancy index between the clinical and histological diagnosis and the prevalence of epithelial dysplasia and carcinoma in 45 patients with potentially malignant ...epithelial oral lesions (PMEL).PATIENTS AND METHODS: We submitted 45 patients with PMEL to clinical examination and obtained a biopsy from each. The results of histological diagnosis were compared to the clinical diagnosis.
RESULTS: Clinical diagnosis showed that the most common PMEL was leukoplakia followed by lichen planus and by actinic cheilitis associated with leukoplakia. The most common site was the buccal mucosa. Histological diagnosis revealed that 46.7% of the PMEL were lichen planus. The discrepancy index between clinical and histological diagnosis was 24.4%. The higher discrepancy index occurred among leukoplakias. The prevalence of epithelial dysplasia and carcinoma was 17.8%.
CONCLUSIONS: We conclude that all PMEL should be submitted to a microscopic analysis because the discrepancy between clinical and histological diagnosis was present in a quarter of these lesionS. Otherwise, the epithelial dysplasia and carcinoma were more frequent in the leukoplakias.
Important industrial applications are based on magnetohydrodynamics (MHD), which concerns the flow of electrically conducting fluids immersed in external magnetic fields. In this work, it is ...performed a 3D numerical analysis of the behavior of a laminar and fully developed flow of a conducting fluid in a duct. Finite Volume Method was used for numerical calculations. Along the initial section of the duct, there are magnets placed around the duct producing magnetic fields in the radial direction. Varying the orientation and intensity of the magnetic fields, two effects are considered: the influence of magnetic field intensity on flow velocity and magnetic field induction due to flow velocity. The analysis is performed at different points along the duct, covering both regions with and without magnets. It was found that the mentioned effects are significant for a particular arrangement of magnets, and for high magnetic fields.
This paper describes an identification process for a class of discrete-time nonlinear systems, which includes the Xilinx system generator software and the process is implemented in a Virtex 7 (V7) ...field programmable gate array (FPGA). This procedure consists of programming a discrete-time nonlinear plant where the dynamics of this plant is reproduced by a discrete-time recurrent high order neural network (RHONN). The neural network is trained on-line with the extended Kalman filter algorithm where the associated state and measurement noises covariance matrices are composed by the coupled variance between the plant states. Additionally, a sliding window-based method for dynamical modeling of nonstationary systems is presented in order to improve the neural identification process. This identification process is implemented on a Virtex 7 (V7) FPGA using Xilinx system generator software where are programed in this FPGA: the discrete-time dynamics of the two degrees of freedom (2DOF) robot manipulator, the RHONN, the extended Kalman filter (EKF) training algorithm and the sliding window-based method. The obtained results from the FPGA are compared with the results obtained from Matlab/SImulink in order to validate the identification process for the present proposal.
Desquamative gingivitis (DG) is a fairly common disorder in which the gingivae show chronic desquamation. Originally considered to be related to hormonal changes at menopause, since many of the ...patients are middle‐aged women, DG is now recognized to be mainly a manifestation of a number of disorders ranging from vesiculobullous diseases to adverse reactions to a variety of chemicals or allergens. Desquamative gingivitis can be an important early clinical manifestation of serious systemic diseases such as pemphigus vulgaris. The authors present a case that illustrates the importance of a specific diagnosis in patients with desquamative gingival lesions previously treated for 6 months as classical gingivitis. Gingival biopsy showed histologic patterns typical of pemphigus vulgaris. The patient was treated with systemic and topical corticosteroids in association with miconazole. The patient is now under control with low‐dose systemic corticosteroids. Proper recognition of lesions in the oral mucosa leads, in several situations, to an early diagnosis of a systemic disease. J Periodontol 1999; 70:808‐812.
HEP-Frame is a new C++ package designed to efficiently perform analyses of data sets from a very large number of events, like those available at the Large Hadron Collider (LHC) at CERN, Geneva. It ...mainly targets high performance servers and mini-clusters, and it was designed for natural science experts with a user-friendly interface to access structured databases. HEP-Frame automatically evaluates the underlying computing resources and builds an adequate code skeleton when creating a data analysis application. In run-time, HEP-Frame analyses a sequence of data sets exploring the available parallelism in the code and hardware resources: it concurrently reads inputs from an user-defined data structure and processes them, following the user specific sequence of requirements to select relevant data; it manages the efficient execution of that sequence; and it outputs results in user-defined objects (e.g., ROOT structures), stored together with the input data used. This paper shows how a domain expert software development can benefit from HEP-Frame, and how it significantly improved the performance of analyses of large data sets produced in proton-proton collisions at the LHC. Two case studies are discussed: the associated production of top quarks together with a Higgs boson (ttH) at the LHC, and a double and single top quark productions at the High-Luminosity phase of the LHC (HL-HLC). Results show that the HEP-Frame awareness of the analysis code behavior and structure, and the underlying hardware system, provides powerful and transparent parallelization mechanisms that largely improve the execution time of data analysis applications.
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