A
bstract
In this note we describe several procedures to construct, from known black-hole and black-brane solutions of any ungauged supergravity theory, non-trivial gravitational solutions whose ...“near-horizon” and “near-singularity” limits are Lifshitz-like spacetimes with dynamical critical exponent
z
, “hyperscaling violation” exponent
θ
and Lifshitz radius
ℓ
that depends on the physical parameters of the original black-hole solution. Since the new Lifshitz-like solutions can be constructed from any black-hole solution of any ungauged supergravity, many of them can be easily embedded in String Theory. Some of the procedures produce supersymmetric Lifshitz-like solutions.
The study reports on the current perception of medical and radiation oncologists regarding teleconsultation in the Philippines. Before the COVID-19 pandemic, the adoption of telemedicine was not ...widespread. With movement restrictions imposed during the pandemic, physicians were compelled to use telemedicine. It is uncertain whether physicians will still adopt its use in practice in the post-COVID-19 era. This study gives insight into the possible adaptation of this mode of consultation in the future, especially in areas with limited health care resources.
We conducted a national survey among medical oncologists and radiation oncologists in the Philippines. A 43-item online survey was developed, validated, and administered to the oncologists. The demographics and data from categorical questions were reported as frequencies and percentages.
A total of 142 responses were gathered from 82 medical oncologists and 60 radiation oncologists. There was agreement among participants that, during the pandemic, teleconsultation could be used for the first visit, diagnostic workup request, treatment explanation, follow-up care, and chronic disease management. There was disagreement whether cancer diagnosis disclosure and cancer prognosis revelation could be performed via teleconsultation, and there was agreement that emergency consultation and physical examination would warrant a face-to-face consultation. After the COVID-19 pandemic, 78.7% intend to continue using teleconsultation except for emergency consultations, first visits, physical examination, diagnosis disclosure, and cancer prognosis revelation.
Teleconsultation was perceived by oncologists as an acceptable method of providing cancer care during and after the COVID-19 pandemic. Oncologists also intend to use teleconsultation in the post-COVID-19 era in certain aspects of patient care.
We use the embedding tensor method to construct the most general maxi-malgauged/massive supergravity in
d
= 9 dimensions and to determine its extended field content. Only the 8 independent ...deformation parameters (embedding tensor components, mass parameters etc.) identified by Bergshoeff et al. (an
triplet, two doublets and a singlet) can be consistently introduced in the theory, but their simultaneous use is subject to a number of quadratic constraints. These constraints have to be kept and enforced because they cannot be used to solve some deformation parameters in terms of the rest. The deformation parameters are associated to the possible 8-forms of the theory, and the constraints are associated to the 9-forms, all of them transforming in the conjugate representations. We also give the field strengths and the gauge and supersymmetry transformations for the electric fields in the most general case. We compare these results with the predictions of the
E
11
approach, finding that the latter predicts one additional doublet of 9-forms, analogously to what happens in
N
= 2
d
= 4, 5, 6 theories.
Purpose
The aim of this study is to review the contemporary evidence comparing neoadjuvant radiotherapy (NRT) versus no radiotherapy (no RT) in patients with stage IV rectal cancer.
Methods
...Literature was searched for studies using the following databases: Pubmed, EMBASE, Science Direct, Scopus, ASCOpubs, the Cochrane Library, and Google Scholar. Studies reporting outcomes for stage IV rectal cancer patients who underwent NRT or no RT were selected.
Results
A total of eight studies were included in this review (one RCT, five retrospective cohorts, two population-based studies). The only RCT in this review reported no significant difference in 2- and 5-year local recurrence (NRT versus no RT) 10.1% versus 23.8%, and 15.9% versus 26.9%, respectively. However, multivariate analysis showed the effect of treatment might not have differed between subgroups according to stage. Pooled analysis from five retrospective studies showed significantly improved local recurrence-free survival (LRFS) with NRT (risk ratio RR 1.15; 95% CI 1.01–1.31,
p
= 0.03), which was maintained in the subgroup who underwent metastasectomy. (RR 1.18; 95% CI 1.01–1.37,
p
= 0.04). Pooled 5-year overall survival (OS) showed a statistically significant benefit with NRT (RR 1.47; 95% CI 1.14–1.89,
p
= 0.003), which was not seen in the subgroup who underwent metastasectomy (RR 1.31; 95% CI 0.94–1.82,
p
= 0.11).
Conclusion
The current available evidence shows an LRFS benefit with NRT over no RT in patients with stage IV rectal cancer. The review also suggests a possible OS benefit with NRT, although this finding should be interpreted with caution.
IIA/IIB supergravity and ten-forms Bergshoeff, E. A.; Hartong, J.; Howe, P. S. ...
The journal of high energy physics,
05/2010, Letnik:
2010, Številka:
5
Journal Article
Recenzirano
Odprti dostop
We perform a careful investigation of which p-form fields can be introduced consistently with the supersymmetry algebra of IIA and/or IIB ten-dimensional supergravity. In particular the ten-forms, ...also known as “top-forms”, require a careful analysis since in this case, as we will show, closure of the supersymmetry algebra at the linear level does
n
ot imply closure at the non-linear level. Consequently, some of the (IIA and IIB) ten-form potentials introduced in earlier work of some of us are discarded. At the same time we show that new ten-form potentials, consistent with the full non-linear supersymmetry algebra can be introduced. We give a superspace explanation of our work. All of our results are precisely in line with the predictions of the
E
11
algebra.
The role of
Fap2 protein in the development of colorectal cancer has recently been explained. Fap2, when bound to the human inhibitory receptor, TIGIT, inhibits the cytotoxic activity of natural ...killer (NK) cells against cancer cells, thus, allowing proliferation of the latter eventually leading to tumor growth. The aim of the study was to identify the immunogenicity of a peptide mimotope of the Fap2 protein and to determine the reactivity of colorectal cancer patients' sera against the mimotope.
Immunogenic epitope of the Fap2 protein of
was selected using the B-cell epitope prediction of the Immune Epitope Database and Analysis Resource (IEDB). The immunogenicity of the synthetic peptide mimotope of the Fap2 protein was determined in animal models and reactivity of colorectal cancer patients' sera against the mimotope was done by indirect ELISA.
Results show that the selected peptide mimotope, with sequence TELAYKHYFGT, of the outer membrane protein Fap2 of
is immunogenic. Increase in the absorbance readings of peptide-immunized rabbit sera was observed starting Week 1 which was sustained up to Week 10 in the indirect ELISA performed. Colorectal cancer cases (
= 37) were all reactive in an ELISA-based analysis using the mimotope as the capture antigen.
In this study, we identified an immunogenic epitope of the Fap2 protein of the
. We demonstrated the reactivity of serum of histopathologically confirmed CRC patients in a peptide-capture indirect ELISA which may serve as proof of concept for the development of CRC diagnostics.
The World Health Organization recognizes depression as one of the most burdensome diseases in the world. Among cancer patients, depression is significantly associated with shorter survival, ...independent of the influence of biomedical prognostic factors. Although cancer is the third leading cause of morbidity and mortality among Filipinos, little is known about depressive symptoms and their influence on health-related quality of life in this population. We assessed the prevalence of, and factors associated with, depressive symptoms and their influence on health-related quality of life in Filipino patients with cancer.
The Patient Health Questionnaire (PHQ)-8 and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 were administered to all inpatients and outpatients, age >=18 years presenting for cancer treatment.
Twenty-two percent (n=53/247) were categorized as depressed, using a PHQ-8 cutoff of ≥10. Depressed patients scored lower on cognitive, emotional, role, physical, and social functioning than those who scored PHQ<10 (all P<0.001). Depression varied by disease status, performance status and marital status (all P<0.001). However, only performance status (OR odds ratio=2.20; 95% CI=1.60, 3.00) and disease status (OR=2.4; 95% CI=1.13, 5.22) were significantly associated with depression in the multivariable model.
Depression is prevalent in Filipino cancer patients. The findings provide empirical support for the development of mental health services in this understudied population. This study, the first to assess the prevalence of and factors associated with depression in Filipino cancer patients, needs further validation.
We study the supersymmetric tensor hierarchy of pure (gauged)
N
= 2,
d
= 4
,
5
,
6 supergravity and compare them with those of the pure, ungauged, theories (worked out in ref.
1
for
d
= 5) and the ...predictions of the Kač-Moody approach made in ref.
2
. We find complete agreement in the ungauged case but we also find that, after gauging, new Stückelberg symmetries reduce the number of independent
physical
top-forms. The analysis has to be performed to all orders in fermion fields.
We discuss the construction of the worldvolume effective actions for the
p
-branes which are charged with respect to the (
p
+ 1)-form potentials and the relations between the tensor hierarchies and
p
-branes upon dimensional reduction.
Purpose
This study aims to review the current evidence on the utility of stereotactic body radiation therapy (SBRT), with or without transarterial chemoembolization (TACE), for early-stage ...hepatocellular carcinoma (ESHCC) patients not amenable to standard curative treatment options.
Methods
Literature search was conducted using PubMed, ScienceDirect, and Google Scholar. Comparative studies reporting oncologic outcomes were included in the review.
Results
Five studies (one phase II randomized controlled trial, one prospective cohort, three retrospective studies) compared SBRT versus TACE. Pooled analysis showed an overall survival (OS) benefit after 3 years (OR 1.65, 95% CI 1.17–2.34,
p
= 0.005) which persisted in the 5-year data (OR 1.53, 95% CI 1.06–2.22,
p
= 0.02) in favor of SBRT. RFS benefit with SBRT was also seen at 3 years (OR 2.06, 95% CI 1.03–4.11,
p
= 0.04) which continued after 5 years (OR 2.35, 95% CI 1.47–3.75,
p
= 0.0004). Pooled 2-year local control (LC) favored SBRT over TACE (OR 2.96, 95% CI 1.89–4.63,
p
< 0.00001). Two retrospective studies compared TACE + SBRT versus TACE alone. Pooled analysis showed significantly improved 3-year OS (OR 5.47; 95% CI 2.47–12.11,
p
< 0.0001) and LC (OR: 21.05; 95% CI 5.01–88.39,
p
≤ 0.0001) in favor of the TACE + SBRT group. A phase III study showed significantly improved LC and PFS with SBRT after failed TACE/TAE versus further TACE/TAE.
Conclusions
Taking into account the limitations of the included studies, our review suggests significantly improved clinical outcomes in all groups having SBRT as a component of treatment versus TACE alone or further TACE. Larger prospective studies are warranted to further define the role of SBRT and TACE for ESHCC.
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